TEAD2 Antibody
(Synonyms: TEF4, TEAD2, Transcriptional enhancer factor TEF-4, TEA domain family member 2, TEAD-2)TEAD2 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to TEAD2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:50-200 |
Product Details
TEAD2 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to TEAD2.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 60 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 49 kDa
Synthetic peptide corresponding to the center region of human TEAD2.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Soulution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TEAD2 is a Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif
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Subcellular Localization
Nucleus
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Isoforms & Post-Translational Modification
TEAD2 has 4 isoforms, Q15562-1: amino acid length is 447, molecular weight is 49243 Da (predicted); Q15562-2: amino acid length is 450, molecular weight is 49569 Da (predicted); Q15562-3: amino acid length is 319, molecular weight is 35403 Da (predicted); Q15562-4: amino acid length is 451, molecular weight is 49640 Da (predicted).TEAD2 存在 4 个异构体，Q15562-1：氨基酸个数为 447 个，分子量为 49243 Da (预测)；Q15562-2：氨基酸个数为 450 个，分子量为 49569 Da (预测)；Q15562-3：氨基酸个数为 319 个，分子量为 35403 Da (预测)；Q15562-4：氨基酸个数为 451 个，分子量为 49640 Da (预测)。
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Subunit
Interacts with YAP1 and WWTR1/TAZ
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SwissProt ID
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Synonyms
TEF4, TEAD2, Transcriptional enhancer factor TEF-4, TEA domain family member 2, TEAD-2
Documentation
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