TEAD-IN-10
TEAD-IN-10 (compound 15) has good selective activity and inhibitory effect on TEAD1 (IC50=14 nM), TEAD2 (IC50=179 nM) and TEAD3 (IC50=4 nnM) as a covalent inhibitor. TEAD-IN-10 can be used for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 3032196-65-6
- Formula: C15H14F3NO
- Molecular Weight:281.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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TAED1 14 nM (IC50) |
TAED2 179 nM (IC50) |
TAED3 4 nM (IC50) |
TEAD-IN-10 has a great inhibition for MCF-7 reporter assay (IC50≤10 nM)[1].
TEAD-IN-10 has a great selectivity for TEAD1 and TEAD2 with 97% and 98% inhibition in HEK293T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NCl-H226 and H2052 cell lines
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Concentration:
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Incubation Time:6 days
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Result:The inhibitory effect of H2052 cell line (IC50≤100 nM) was better than that of NCl-H226 cell line (IC50:100-500 nM).
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Cell Line:NCl-H226 and H2052 cell lines
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Concentration:
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Incubation Time:7 days
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Result:The inhibition rate of anti-proliferation of both cell lines was greater than 75%.
Chemical Information
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CAS No. 3032196-65-6
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Molecular Weight 281.27
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Formula C15H14F3NO
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SMILES
O=C(C=C)N(C1)CC1/C=C/C2=CC=C(C(F)(F)F)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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