PROTAC TEAD degrader-3
PROTAC TEAD degrader-3 is a TEAD PROTAC degrader with an IC50 of < 5 nM against TEAD1, TEAD2, TEAD3 and TEAD4. PROTAC TEAD degrader-3 promotes ubiquitination and degradation of TEAD1/2/3/4. PROTAC TEAD degrader-3 can be used in cancer research.
(Pink: TEAD1 and TEAD2 and TEAD3 and TEAD4 ligand (HY-186023); Blue: E3 ligase ligand; Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 3120075-62-6
- Formula: C54H59ClF4N8O6
- Molecular Weight:1027.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TEAD1 <5 nM (IC50) |
TEAD2 <5 nM (IC50) |
TEAD3 <5 nM (IC50) |
TEAD4 <5 nM (IC50) |
Chemical Information
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CAS No. 3120075-62-6
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Molecular Weight 1027.54
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Formula C54H59ClF4N8O6
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SMILES
COC1=C(F)[C@@]([C@@]2=C(Cl)C(F)=CC3=C2[C@H](C)[C@@](CN[C@H]4CC[C@H](C(N5CCC(CN6CCC(C7=C(F)C(N(C)N=C8N9CCC(NC9=O)=O)=C8C=C7F)CC6)CC5)=O)CC4)(C%10=CC=CC=C%10)O3)=C(C(N)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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