PROTAC TEAD degrader-3
PROTAC TEAD degrader-3 is a TEAD PROTAC degrader with an IC50 of < 5 nM against TEAD1, TEAD2, TEAD3 and TEAD4. PROTAC TEAD degrader-3 promotes ubiquitination and degradation of TEAD1/2/3/4. PROTAC TEAD degrader-3 can be used in cancer research.
(Pink: TEAD1 and TEAD2 and TEAD3 and TEAD4 ligand (HY-186023); Blue: E3 ligase ligand; Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 3120075-62-6
- Formula: C54H59ClF4N8O6
- Molecular Weight:1027.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
TEAD1 <5 nM (IC50) |
TEAD2 <5 nM (IC50) |
TEAD3 <5 nM (IC50) |
TEAD4 <5 nM (IC50) |
In Vitro
PROTAC TEAD degrader-3 (Compound 106A) potently degrades HiBit-tagged TEAD1, TEAD2, TEAD3, and TEAD4 in HEK293 cells, with an IC50 < 5 nM for each isoform[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 3120075-62-6
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Molecular Weight 1027.54
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Formula C54H59ClF4N8O6
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SMILES
COC1=C(F)[C@@]([C@@]2=C(Cl)C(F)=CC3=C2[C@H](C)[C@@](CN[C@H]4CC[C@H](C(N5CCC(CN6CCC(C7=C(F)C(N(C)N=C8N9CCC(NC9=O)=O)=C8C=C7F)CC6)CC5)=O)CC4)(C%10=CC=CC=C%10)O3)=C(C(N)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC TEAD degrader-3 Related Classifications
HY-184225 Related Classifications
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