TEAD1 - TEA domain transcription factor 1 Gene

Also Known as AA; REF1; TCF13; TEF-1; NTEF-1; TCF-13; TEAD-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7003

About TEAD1

Cytogenetic location: 11p15.3 Genomic coordinates (GRCh38): 11:12,674,421-12,944,737 (from NCBI)

This gene has 6 transcripts (splice variants), 210 orthologues, 3 paralogues and is associated with 3 phenotypes. Ubiquitous expression in fat (RPKM 17.6), esophagus (RPKM 16.7) and 24 other tissues.

Summary

This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010]

TEAD1 Products (1)

mRNA Protein Name
NM_021961.6 NP_068780.2 transcriptional enhancer factor TEF-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
18579750 GOA
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
20123905 GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
26045994 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
26045994 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9869635 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in hippo signaling IDA
IDA: Inferred from direct assay
18579750 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
20123905 GOA
involved in positive regulation of cell growth IDA
IDA: Inferred from direct assay
18579750 GOA
involved in positive regulation of miRNA transcription IMP
IMP: Inferred from mutant phenotype
26045994 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20123905 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
25796446 GOA
involved in protein-containing complex assembly IMP
IMP: Inferred from mutant phenotype
20123905 GOA
Cellular Component GO Annotation Evidence References Source
part of TEAD-YAP complex IDA
IDA: Inferred from direct assay
20123905 GOA
part of TEAD-YAP complex IPI
IPI: Inferred from physical interaction
25384421 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TEAD1 Protein Structure

TEA

TEA: TEA/ATTS domain family (9 - 418)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 426 a.a.
Protein Preferred Names Protein Names

transcriptional enhancer factor TEF-1

  • TEA domain family member 1 (SV40 transcriptional enhancer factor)

TEAD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TEAD1 P28347 YAP1 Homo sapiens P46937
Anti Tag CoIP
26258633
Intra
TEAD1 P28347 YAP1 Homo sapiens P46937
BioID
35140242
Intra
TEAD1 P28347 YAP1 Homo sapiens P46937
Anti Bait CoIP
26258633
Intra
TEAD1 P28347 YAP1 Homo sapiens P46937
Anti Bait CoIP
24882516
Intra
TEAD1 P28347 RAD51 Homo sapiens Q06609
Anti Tag CoIP
33961781
Intra
TEAD1 P28347 RAD51 Homo sapiens Q06609
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

TEAD1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82209 TEF1/TEAD-1 Antibody (YA1954) WB, IHC-P, IP Human, Mouse, Rat
HY-P82377 TEF1/TEAD-1 Antibody (YA2122) WB Human

Related Diseases

Diseases Alias
Sveinsson Chorioretinal Atrophy

  • SCRA

  • Atrophia Areata

  • Helicoid Peripapillary Chorioretinal Degeneration

  • Hpcd

  • Aa

  • Peripapillary Chorioretinal Degeneration, Icelandic Type

  • Helicoidal Peripapillary Chorioretinal Degeneration

  • Atrophy, Chorioretinal, Sveinsson
Aicardi Syndrome

  • AIC

  • Corpus Callosum, Agenesis Of, With Chorioretinal Abnormality

  • Agenesis Of Corpus Callosum With Chorioretinal Abnormality

  • Aicardi'S Syndrome

  • Agenesis Of Corpus Callosum With Infantile Spasms And Ocular Abnormalities

  • Callosal Agenesis And Ocular Abnormalities

  • Chorioretinal Anomalies With Acc
Spindle Cell Rhabdomyosarcoma
Neurofibroma

  • Neurofibromas

  • Neurofibromatoses

  • Nerve Sheath Tumors
Embryonal Rhabdomyosarcoma

  • Rhabdomyosarcoma, Embryonal

  • Rhabdomyosarcoma Embryonal

  • Botryoid Rhabdomyosarcoma

  • Erms

  • Spindle Cell Rhabdomyosarcomas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-172113 H122 98.33% Phase 4

Pre-clinical Phase

Bioactive Molecules (49)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-134956 VT104 Inhibitor 99.94% Unkown
HY-134955 VT103 Inhibitor 99.64% Unkown
HY-147135 MYF-03-69 98.11% Unkown
HY-147136 MYF-03-176 Inhibitor 99.72% Unkown
HY-P2244 YAP-TEAD-IN-1 Inhibitor 99.68% Unkown
HY-174275 TEAD1/3/4-IN-1 Inhibitor 99.04% Unkown
HY-P2244A YAP-TEAD-IN-1 TFA Inhibitor 99.99% Unkown
HY-147208 MSC-4106 Inhibitor 99.87% Unkown
HY-147088 TEAD-IN-2 Inhibitor 98.14% Unkown
HY-161569 TEAD-IN-11 Inhibitor 99.82% Unkown
HY-186117 KG-FP-003 Degrader / Unkown
HY-147209 DC-TEAD3in03 Inhibitor / Unkown
HY-161443 TEAD-IN-9 Inhibitor / Unkown
HY-161568 TEAD-IN-10 Inhibitor / Unkown
HY-168506 MSC-1254 Inhibitor / Unkown
HY-170764 M3686 Inhibitor / Unkown
HY-173139 TEAD-IN-19 Inhibitor / Unkown
HY-181530 IAP ligand 6 Ligand / Unkown
HY-181532 IAP ligand 8 Ligand / Unkown
HY-181533 IAP ligand 9 Ligand / Unkown
HY-181534 PROTAC TEAD1/IAP degrader-1 Degrader / Unkown
HY-181536 TEAD ligand 2 Ligand / Unkown
HY-181537 PROTAC TEAD1/IAP degrader-2 / Unkown
HY-181590 PROTAC TEAD1/IAP degrader-3 Degrader / Unkown
HY-181591 IAP ligand 10 / Unkown
HY-181592 TEAD ligand 4 Degrader / Unkown
HY-181593 IAP ligand-Linker Conjugate 2 / Unkown
HY-181594 PROTAC TEAD/IAP degrader-1 Degrader / Unkown
HY-182672 VT101 Inhibitor / Unkown
HY-182673 VT102 Inhibitor / Unkown
HY-183728 LC-TEAD01 Inhibitor / Unkown
HY-183753 LC-TD-05 / Unkown
HY-184225 PROTAC TEAD degrader-3 Degrader / Unkown
HY-185230 HC278 Degrader / Unkown
HY-186021 PROTAC TEAD degrader-2 Degrader / Unkown
HY-186022 YAP/TAZ-TEAD-IN-3 Inhibitor / Unkown
HY-186023 TEAD ligand-Linker Conjugate 1 / Unkown
HY-186118 TEAD ligand 6 Ligand / Unkown
HY-RS14342 TEAD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W803227 1-(2-Chloro-acetyl)-piperazine / Unkown
HY-168505 MSC-5046 Inhibitor / Unkown
HY-169316 YAP/TAZ inhibitor-4 Inhibitor / Unkown
HY-181535 IAP ligand-Linker Conjugate 1 Ligand / Unkown
HY-181538 TEAD ligand 3 Ligand / Unkown
HY-181539 TEAD ligand-Linker Conjugate 2 / Unkown
HY-181607 TEAD ligand-Linker Conjugate 3 Degrader / Unkown
HY-208734 YAP1/TEAD negative control-1 / Unkown
HY-RS17084 Tead1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23528 Tead1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TEAD1 VGNC VGNC:47228
Mus musculus TEAD1 MGD MGI:101876
Macaca mulatta TEAD1 VGNC VGNC:78301
Felis catus TEAD1 VGNC VGNC:66053
Bos taurus TEAD1 VGNC VGNC:35724
Rattus norvegicus TEAD1 RGD RGD:1549742
Others TEAD1 NCBI