RAD51 - RAD51 recombinase Gene

Also Known as RECA; BRCC5; FANCR; MRMV2; HRAD51; RAD51A; HsRad51; HsT16930

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5888

About RAD51

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,694,733-40,732,340 (from NCBI)

This gene has 11 transcripts (splice variants), 220 orthologues, 6 paralogues and is associated with 7 phenotypes. Biased expression in testis (RPKM 6.6), bone marrow (RPKM 3.5) and 13 other tissues.

Summary

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to Bacterial RecA and Saccharomyces cerevisiae RAD51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

RAD51 Products (10)

mRNA	Protein	Name
NM_001164269.2	NP_001157741.1	DNA repair protein RAD51 homolog 1 isoform 2
XM_011521857.3	XP_011520159.2	DNA repair protein RAD51 homolog 1 isoform X1
NM_001164270.2	NP_001157742.1	DNA repair protein RAD51 homolog 1 isoform 3
XM_011521860.3	XP_011520162.1	DNA repair protein RAD51 homolog 1 isoform X2
NM_002875.5	NP_002866.2	DNA repair protein RAD51 homolog 1 isoform 1
XM_047432925.1	XP_047288881.1	DNA repair protein RAD51 homolog 1 isoform X4
XM_011521861.3	XP_011520163.2	DNA repair protein RAD51 homolog 1 isoform X3
NM_133487.4	NP_597994.3	DNA repair protein RAD51 homolog 1 isoform 2
XM_011521859.3	XP_011520161.1	DNA repair protein RAD51 homolog 1 isoform X2
XM_011521858.3	XP_011520160.1	DNA repair protein RAD51 homolog 1 isoform X2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	16428451	GOA
enables DNA polymerase binding	IPI IPI: Inferred from physical interaction	19995904	GOA
enables DNA strand exchange activity	IDA IDA: Inferred from direct assay	18417535	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	23401855	GOA
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	7988572	GOA
enables double-stranded DNA binding	IMP IMP: Inferred from mutant phenotype	26681308	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	23401855	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	9396801	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8675009	GOA
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	7988572	GOA
enables single-stranded DNA binding	IMP IMP: Inferred from mutant phenotype	26681308	GOA
enables single-stranded DNA helicase activity	IDA IDA: Inferred from direct assay	7988572	GOA
enables single-stranded DNA helicase activity	IMP IMP: Inferred from mutant phenotype	26681308	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	17996710	GOA
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	26681308	GOA
involved in DNA recombinase assembly	IMP IMP: Inferred from mutant phenotype	26681308	GOA
involved in DNA unwinding involved in DNA replication	IDA IDA: Inferred from direct assay	7988572	GOA
involved in cellular response to camptothecin	IDA IDA: Inferred from direct assay	23509288	GOA
involved in cellular response to ionizing radiation	IDA IDA: Inferred from direct assay	23509288	GOA
involved in cellular response to ionizing radiation	IMP IMP: Inferred from mutant phenotype	14636569	GOA
acts upstream of or within double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	16428451	GOA
involved in double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	17996710	GOA
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	22778135	GOA
involved in interstrand cross-link repair	IMP IMP: Inferred from mutant phenotype	26253028	GOA
involved in positive regulation of DNA ligation	IDA IDA: Inferred from direct assay	8929543	GOA
involved in regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	23754376	GOA
involved in replication fork processing	IDA IDA: Inferred from direct assay	18417535	GOA
involved in replication fork processing	IMP IMP: Inferred from mutant phenotype	22778135	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in PML body	IDA IDA: Inferred from direct assay	11309417	GOA
located in chromatin	IDA IDA: Inferred from direct assay	25585578	GOA
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	21076401	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16215984	GOA
located in lateral element	IDA IDA: Inferred from direct assay	9774970	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	20413593	GOA
located in nuclear chromosome	IDA IDA: Inferred from direct assay	23754376	GOA
part of nuclear ubiquitin ligase complex	IDA IDA: Inferred from direct assay	14636569	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12442171	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16215984	GOA
is active in presynaptic intermediate filament cytoskeleton	IDA IDA: Inferred from direct assay	18003859	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	16990250	GOA
is active in site of double-strand break	IDA IDA: Inferred from direct assay	26811421	GOA
located in site of double-strand break	IDA IDA: Inferred from direct assay	24550317	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAD51 Protein Structure

HHH_5

Rad51

0
100
200
300
339 a.a.

Protein Preferred Names	Protein Names
DNA repair protein RAD51 homolog 1	BRCA1/BRCA2-containing complex, subunit 5 RAD51 homolog A RecA, E. coli, homolog of RecA-like protein recombination protein A

RAD51 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAD51	Q06609	SPIDR	Homo sapiens	Q14159	Anti Bait CoIP	23509288
Intra	RAD51	Q06609	SPIDR	Homo sapiens	Q14159	Pull Down	23509288
Intra	RAD51	Q06609	SPIDR	Homo sapiens	Q14159	Anti Tag CoIP	23509288
Intra	RAD51	Q06609	RAD51AP1	Homo sapiens	Q96B01-2	Y2H	9396801
Intra	RAD51	Q06609	RAD51AP1	Homo sapiens	Q96B01-3	Pull Down	21307306
Intra	RAD51	Q06609	RAD51AP1	Homo sapiens	Q96B01-3	Pull Down	21903585
Intra	RAD51	Q06609	PALB2	Homo sapiens	Q86YC2	Pull Down	24141787
Intra	RAD51	Q06609	RAD51C	Homo sapiens	O43502	Anti Bait CoIP	16395335
Intra	RAD51	Q06609	XRCC3	Homo sapiens	O43542	Y2H	28864920
Intra	RAD51	Q06609	BRCA2	Homo sapiens	P51587	Pull Down	15800615
Intra	RAD51	Q06609	BRCA2	Homo sapiens	P51587	Pull Down	17541404
Intra	RAD51	Q06609	BRCA2	Homo sapiens	P51587	Anti Tag CoIP	15800615
Intra	RAD51	Q06609	NSD3	Homo sapiens	Q9BZ95	Y2H Array	25640309
Intra	RAD51	Q06609	NSD3	Homo sapiens	Q9BZ95	Anti Tag CoIP	25640309
Intra	RAD51	Q06609	SWSAP1	Homo sapiens	Q6NVH7	Pull Down	21965664
Intra	RAD51	Q06609	RAD52	Homo sapiens	P43351	Anti Tag CoIP	19338310
Intra	RAD51	Q06609	RAD52	Homo sapiens	P43351	Y2H	12750383
Intra	RAD51	Q06609	RAD52	Homo sapiens	P43351	Y2H	19338310
Intra	RAD51	Q06609	NAT2	Homo sapiens	P11245	Y2H Array	25640309
Intra	RAD51	Q06609	LRATD2	Homo sapiens	Q96KN1	Anti Tag CoIP	25640309

Cross: Cross-species interaction Intra: Intraspecies interaction

RAD51 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80297	Rad51 Antibody (YA108)	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse, Rat
HY-P85527	Rad51 Antibody (YA5219)	WB	Human, Mouse, Rat, Monkey
HY-P86467	Rad51 Antibody (YA6159)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Werner Syndrome	Werner'S Syndrome WRN Adult Progeria Ws Adult Premature Ageing Syndrome Adult Premature Aging Syndrome Werners Syndrome
Fallopian Tube Disease	Fallopian Tube Diseases
Spastic Paraplegia 84, Autosomal Recessive	SPG84 Hereditary Spastic Paraplegia 84 Spastic Paraplegia 84 Autosomal Recessive Doid:0112347
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Pontocerebellar Hypoplasia, Type 2e	Pontocerebellar Hypoplasia Type 2 Pontocerebellar Hypoplasia Type 2e Pch2 PCH2E Progressive Microcephaly From Birth Extrapyramidal Dyskinesia Chorea Epilepsy Pontocerebellar Hypoplasia 2e Pcca2 Progressive Cerebello-Cerebral Atrophy Type 2 Doid:0112328 Hypoplasia, Pontocerebellar, Type 2e Pontocerebellar Hypoplasia, Type 2d Pontocerebellar Hypoplasia Type 2a
Immunodeficiency 25	Immunodeficiency Due To Defect In Cd3-Zeta IMD25 Immunodeficiency, Type 25
Autosomal Recessive Cerebellar Ataxia	Arca
Alternating Hemiplegia Of Childhood	Alternating Hemiplegia Ahc Alternating Hemiplegia Syndrome Hemiplegia, Alternating, Of Childhood Hemiplegia, Crossed
Spastic Paraplegia 85, Autosomal Recessive	SPG85 Hereditary Spastic Paraplegia 85 Spastic Paraplegia 85 Autosomal Recessive Doid:0112345
Sporadic Breast Cancer	Sporadic Breast Carcinoma
Pontocerebellar Hypoplasia	Pch Congenital Pontocerebellar Hypoplasia Opch Hypoplasia, Pontocerebellar Pontoneocerebellar Hypoplasia Nonsyndromic Pontocerebellar Hypoplasia
Spastic Paraplegia 86, Autosomal Recessive	SPG86 Hereditary Spastic Paraplegia 86 Spastic Paraplegia 86 Autosomal Recessive Doid:0112342
Li-Fraumeni Syndrome	Sarcoma Family Syndrome Of Li And Fraumeni Sbla Syndrome LFS Li-Fraumeni Familiar Cancer Susceptibility Syndrome Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome Lfs1 Li Fraumeni Syndrome Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome Lfl Sbla Syndrome Li-Fraumeni-Like Syndrome Li-Fraumeni Syndrome 1
Fanconi Anemia, Complementation Group R	Fanconi Anemia Complementation Group R FANCR
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Neuroma
Bloom Syndrome	BLM Bs Bls Bloom-Torre-Machacek Syndrome Microcephaly, Growth Restriction, And Increased Sister Chromatid Exchange 1 Mgrisce1 Congenital Telangiectatic Erythema Congenital Telangiectatic Erythema Syndrome Growth Deficiency, Sun-Sensitive, Telangiectatic, Hypo And Hyperpigmented Skin, Predisposition To Malignancy And Chromosomal Instability Bloom'S Syndrome Bsyn
Fanconi Anemia, Complementation Group D2	Fanconi Anemia Complementation Group D2 FANCD2 Fad2 Fa4 Fancd Fanconi Pancytopenia Type 4 Fanconi Anemia, Complementation Group D Fanconi Pancytopenia, Type 4 Facd Fanconi Anemia Complementation Group D
Haverhill Fever	Streptobacillosis Streptobacillary Rat-Bite Fever Streptobacillary Fever Rat-Bite Fever Due To Streptobacillus Moniliformis Erythema Arthriticum Epidemicum Epidemic Arthritic Erythema
Physical Disorder	Physical Illness
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Rothmund-Thomson Syndrome, Type 2	Rothmund-Thomson Syndrome Rts RTS2 Poikiloderma Of Rothmund-Thomson Rothmund-Thomson Syndrome Type 2 Congenital Poikiloderma Poikiloderma Congenitale Poikiloderma Atrophicans And Cataract Poikiloderma Congenitale Of Rothmund-Thomson Poikiloderma Of Rothmund-Thomson Type 2 Rothmund-Thomson Syndrome 2 Erythrokeratodermia Variabilis
Trichohepatoenteric Syndrome 1	Trichohepatoenteric Syndrome Syndromic Diarrhea Tricho-Hepato-Enteric Syndrome Sd/The Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome THES1 Phenotypic Diarrhea Thes Phenotypic Diarrhea Of Infancy Diarrhea, Syndromic Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa Intractable Diarrhea With Phenotypic Anomalies Syndromatic Diarrhea Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis De Sanctis-Cacchione Syndrome Xp Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Glanders	Farcy Pipes Infection Due To Pseudomonas Mallei Burkholderia Mallei Burkholderia Mallei Infection Equina Equine Glanders Farcy Farcy Buds Farcy Cords Infection Due To Actinobacillus Mallei Infection Due To Malleomyces Mallei Maliasmus Malleus Farce Actinobacillosis Actinobacillus Infection
Ataxia-Telangiectasia	Ataxia Telangiectasia Louis-Bar Syndrome AT At1 Ataxia-Telangiectasia Syndrome Ataxia - Telangiectasia Variant Boder-Sedgwick Syndrome Louis Bar Syndrome Cerebello-Oculocutaneous Telangiectasia Immunodeficiency With Ataxia Telangiectasia A-T Ataxia Telangiectasia Syndrome Atm Telangiectasia, Cerebello-Oculocutaneous Ataxia-Telangiectasia Variant
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Lynch Syndrome	Hereditary Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Carcinoma Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hnpcc Coca 1 Hereditary Defective Mismatch Repair Syndrome Hereditary Non-Polyposis Colon Cancer Hereditary Non-Polyposis Colon Cancer Syndrome Hereditary Non-Polyposis Colorectal Cancer Hereditary Non-Polyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colon Cancer Syndrome Hereditary Nonpolyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colorectal Neoplasm Hnpcc - Hereditary Nonpolyposis Colon Cancer Cancer Family Syndrome Familial Nonpolyposis Colorectal Cancer Colon Cancer, Familial Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cancer, Colorectal, Nonpolyposis, Hereditary Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Fanconi Anemia, Complementation Group D1	Fanconi Anemia Complementation Group D1 FANCD1 Fad1 Inherited Cancer-Predisposing Syndrome Due To Biallelic Brca2 Mutations
Cerebellar Disease	Cerebellar Diseases Cerebellar Dysfunction Cerebellar Abnormality Cerebellar Disorders
Mirror Movements 1	Congenital Mirror Movement Disorder Bimanual Synergia Congenital Mirror Movements Familial Congenital Controlateral Synkinesia Familial Congenital Mirror Movements Hereditary Congenital Controlateral Synkinesia Hereditary Congenital Mirror Movements Isolated Congenital Controlateral Synkinesia Isolated Congenital Mirror Movements Mirror Movements MRMV1 Mirror Movements 1 And/Or Agenesis Of The Corpus Callosum Mirror Movements, Congenital Bimanual Synkinesis Cmm Mirror Movements, Type 1
Trichothiodystrophy	Ttd Amish Brittle Hair Syndrome Bids Syndrome Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome Ibids Pibids Trichothiodystrophy Syndromes
Nijmegen Breakage Syndrome	Berlin Breakage Syndrome NBS Microcephaly, Normal Intelligence And Immunodeficiency Ataxia-Telangiectasia Variant Ataxia-Telangiectasia Variant V1 Seemanova Syndrome Ii Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome Seemanova Syndrome Type 2 At-V1 Microcephaly With Normal Intelligence, Immunodeficiency, And Lymphoreticular Malignancies Nonsyndromal Microcephaly, Autosomal Recessive, With Normal Intelligence Immunodeficiency, Microcephaly, And Chromosomal Instability Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome Microcephaly Immunodeficiency Lymphoreticuloma Microcephaly With Normal Intelligence Immunodeficiency And Lymphoreticular Malignancies Nonsyndromal Microcephaly Autosomal Recessive With Normal Intelligence Seemanova Syndrome 2 Ataxia-Telangiectasia Variant 1 Seemanova Syndrome At V1 Ataxia-Telangiectasia, Variant 1 Microcephaly-Immunodeficiency-Lymphoid Malignancy Syndrome V-At Ataxia Telangiectasia Variant V1
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism
Parkinsonism With Spasticity, X-Linked	X-Linked Parkinsonism-Spasticity Syndrome XPDS X-Linked Parkinsonism With Spasticity
Cockayne Syndrome A	Cockayne Syndrome Type 1 Cockayne Syndrome, Type A Cockayne Syndrome Type I CSA Cockayne Syndrome Classic Form Cockayne Syndrome Classical Cockayne Syndrome Type A Ckn1
Bilateral Breast Cancer	Bilateral Breast Carcinoma
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Pancreatic Adenocarcinoma	Adenocarcinoma Of Pancreas Adenocarcinoma Of The Pancreas Pancreas Adenocarcinoma Malignant Exocrine Neoplasm Primary Pancreatic Adenocarcinoma Adenocarcinoma Of Islet Cell Of Pancreas Islet Cell Adenocarcinoma Of Unspecified Site Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Cervix Melanoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Mirror Movements 2	MRMV2 Mirror Movements, Type 2
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple
Malignant Renovascular Hypertension	Secondary Malignant Renovascular Hypertension

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-19793	RS-1	Activator	99.77%	Phase 2
HY-111887	Emzadirib	Inhibitor	99.32%	Phase 2
HY-10206	Amuvatinib	Inhibitor	99.40%	Phase 2
HY-10206A	Amuvatinib hydrochloride	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (38)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D0086	DIDS sodium salt	Inhibitor	99.13%	Unkown
HY-101462	RAD51 Inhibitor B02	Inhibitor	99.89%	Unkown
HY-15317	RI-1	Inhibitor	99.83%	Unkown
HY-103710	IBR2	Inhibitor	98.24%	Unkown
HY-150147	CAM833	Inhibitor	99.83%	Unkown
HY-126020	Bractoppin	Inhibitor	99.90%	Unkown
HY-N3980	Guaiol		99.67%	Unkown
HY-N7271	Solanidine	Inhibitor	99.90%	Unkown
HY-163944	LL-K12-18	Modulator	98.42%	Unkown
HY-16904	RI-2	Inhibitor	99.90%	Unkown
HY-148183	Homologous recombination-IN-1	Inhibitor	98.65%	Unkown
HY-126972A	RI(dl)-2 TFA	Inhibitor	98.8%	Unkown
HY-122705	RAD51-IN-1	Inhibitor	99.18%	Unkown
HY-143736	RAD51-IN-5	Inhibitor	98.87%	Unkown
HY-136604	RAD51-IN-3	Inhibitor	99.60%	Unkown
HY-176549	(Rac)-IBR120	Inhibitor	99.65%	Unkown
HY-143735	RAD51-IN-4	Inhibitor	/	Unkown
HY-143737	RAD51-IN-6	Inhibitor	/	Unkown
HY-143741	RAD51-IN-7	Inhibitor	/	Unkown
HY-178022	HDAC6-IN-63	Inhibitor	/	Unkown
HY-181694	SeSA-HCPT	Inhibitor	/	Unkown
HY-181651	SZU305	Degrader	/	Unkown
HY-178021	HDAC1-IN-11	Inhibitor	/	Unkown
HY-173345	BRCA2-RAD51-IN-2	Inhibitor	/	Unkown
HY-103710A	(R)-IBR2	Control	/	Unkown
HY-170907	HDAC-IN-85	Inducer	/	Unkown
HY-126972	RI(dl)-2	Inhibitor	/	Unkown
HY-P10516	BRC4 peptide		/	Unkown
HY-121693	DIDS	Inhibitor	/	Unkown
HY-169213	LN-439A	Inhibitor	/	Unkown
HY-150958	RAD51-IN-8		/	Unkown
HY-N7271R	Solanidine (Standard)	Inhibitor	/	Unkown
HY-115533	LBL1	Inhibitor	/	Unkown
HY-122583	D-G23	Inhibitor	/	Unkown
HY-169622	RAD51-IN-9	Inhibitor	/	Unkown
HY-172252	CSN5-IN-2	Inhibitor	/	Unkown
HY-162104	BRCA2-RAD51-IN-1	Inhibitor	/	Unkown
HY-181561	BRCA2-RAD51-IN-3	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RAD51	RGD	RGD:1563603
Felis catus	RAD51	VGNC	VGNC:69215
Macaca mulatta	RAD51	VGNC	VGNC:76645
Mus musculus	RAD51	MGD	MGI:97890
Bos taurus	RAD51	VGNC	VGNC:33684
Canis familiaris	RAD51	VGNC	VGNC:45317
Others	RAD51	NCBI