XRCC3 - X-ray repair cross complementing 3 Gene

Also Known as CMM6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7517

About XRCC3

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:103,697,617-103,715,451 (from NCBI)

This gene has 18 transcripts (splice variants), 191 orthologues, 6 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 5.7), skin (RPKM 5.6) and 25 other tissues.

Summary

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with Cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

XRCC3 Products (6)

mRNA	Protein	Name
NM_001100118.2	NP_001093588.1	DNA repair protein XRCC3
NM_001100119.2	NP_001093589.1	DNA repair protein XRCC3
NM_001371229.1	NP_001358158.1	DNA repair protein XRCC3
NM_001371231.1	NP_001358160.1	DNA repair protein XRCC3
NM_001371232.1	NP_001358161.1	DNA repair protein XRCC3
NM_005432.4	NP_005423.1	DNA repair protein XRCC3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to crossover junction DNA endonuclease activity	IMP IMP: Inferred from mutant phenotype	14716019	GOA
contributes to four-way junction DNA binding	IDA IDA: Inferred from direct assay	20207730	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9469824	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA repair	IGI IGI: Inferred from genetic interaction	10422536	GOA
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	23149936	GOA
involved in interstrand cross-link repair	IMP IMP: Inferred from mutant phenotype	26323318	GOA
involved in positive regulation of mitotic cell cycle spindle assembly checkpoint	IMP IMP: Inferred from mutant phenotype	23108668	GOA
involved in regulation of centrosome duplication	IMP IMP: Inferred from mutant phenotype	23108668	GOA
involved in resolution of mitotic recombination intermediates	IMP IMP: Inferred from mutant phenotype	23108668	GOA
involved in t-circle formation	IMP IMP: Inferred from mutant phenotype	21903669	GOA
involved in telomere maintenance via recombination	IMP IMP: Inferred from mutant phenotype	15507207	GOA
involved in telomere maintenance via telomere trimming	IGI IGI: Inferred from genetic interaction	27918544	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Rad51C-XRCC3 complex	IDA IDA: Inferred from direct assay	11751635	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16215984	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	20413593	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16215984	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16215984	GOA
located in replication fork	IDA IDA: Inferred from direct assay	20207730	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XRCC3 Protein Structure

Rad51

0
100
200
300
346 a.a.

Protein Preferred Names	Protein Names
DNA repair protein XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 3

XRCC3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	XRCC3	O43542	PALB2	Homo sapiens	Q86YC2	Anti Bait CoIP	24141787
Intra	XRCC3	O43542	PALB2	Homo sapiens	Q86YC2	Pull Down	24141787
Intra	XRCC3	O43542	RAD51C	Homo sapiens	O43502	Anti Bait CoIP	24141787
Intra	XRCC3	O43542	RAD51C	Homo sapiens	O43502	Y2H	9469824
Intra	XRCC3	O43542	RAD51C	Homo sapiens	O43502	Anti Tag CoIP	11842113
Intra	XRCC3	O43542	RAD51C	Homo sapiens	O43502	Pull Down	11751635
Intra	XRCC3	O43542	RAD51C	Homo sapiens	O43502	Anti Tag CoIP	26496610
Intra	XRCC3	O43542	RAD51	Homo sapiens	Q06609	Anti Tag CoIP	11842113
Intra	XRCC3	O43542	RAD51	Homo sapiens	Q06609	Y2H	9660962
Intra	XRCC3	O43542	RAD51	Homo sapiens	Q06609	Anti Tag CoIP	9660962
Intra	XRCC3	O43542	SWSAP1	Homo sapiens	Q6NVH7	Anti Tag CoIP	21965664
Intra	XRCC3	O43542	SWSAP1	Homo sapiens	Q6NVH7	Pull Down	21965664

Cross: Cross-species interaction Intra: Intraspecies interaction

XRCC3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82239	XRCC3 Antibody (YA1984)	WB, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Melanoma, Cutaneous Malignant 6	Melanoma, Cutaneous Malignant, Susceptibility To, 6 CMM6 Melanoma, Cutaneous Malignant, 6 Cutaneous Malignant Melanoma 6 Melanoma, Cutaneous, Malignant, Susceptibility To, Type 6
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Xeroderma Pigmentosum, Complementation Group D	Xeroderma Pigmentosum, Group D Xpdc Xeroderma Pigmentosum Iv XPD Xeroderma Pigmentosum Group D Xeroderma Pigmentosum Viii Xp Group D Xp Group H Xp4 Xp8 Xph Xp, Group D Xp4 Xeroderma Pigmentosum Viii, Formerly Xp8, Formerly Xp, Group H, Formerly Xph, Formerly Xeroderma Pigmentosum Complementation Group D XP-D Xp-D/Cs
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Cervix Melanoma
Skin Carcinoma	Skin Cancer Carcinoma Of Skin Ca - Skin Cancer Cancer Of Skin Malignant Neoplasm Of Skin Melanoma And Non-Melanoma Skin Cancer Skin Cancers Cancer, Skin
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Xeroderma Pigmentosum, Complementation Group G	Xeroderma Pigmentosum, Group G Xeroderma Pigmentosum Vii Xp7 XPG Xeroderma Pigmentosum Group G Xp Group G Xp, Group G Xpgc Xeroderma Pigmentosum, Group G/Cockayne Syndrome Xeroderma Pigmentosum, Type 7 Xeroderma Pigmentosum Complementation Group G XP-G Xp-G/Cs Xeroderma Pigmentosum Group G/Cockayne Syndrome
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15898	XRCC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22923	Xrcc3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29437	Xrcc3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	XRCC3	VGNC	VGNC:99342
Canis familiaris	XRCC3	VGNC	VGNC:48467
Felis catus	XRCC3	VGNC	VGNC:67118
Bos taurus	XRCC3	VGNC	VGNC:37004
Rattus norvegicus	XRCC3	RGD	RGD:1306849
Mus musculus	XRCC3	MGD	MGI:1921585
Others	XRCC3	NCBI