RAD51C - RAD51 paralog C Gene

Also Known as FANCO; R51H3; BROVCA3; RAD51L2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5889

About RAD51C

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:58,692,573-58,735,611 (from NCBI)

This gene has 38 transcripts (splice variants), 204 orthologues, 6 paralogues and is associated with 7 phenotypes. Ubiquitous expression in testis (RPKM 9.7), brain (RPKM 5.4) and 25 other tissues.

Summary

This gene is a member of the RAD51 family. RAD51 family members are highly similar to Bacterial RecA and Saccharomyces cerevisiae RAD51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

RAD51C Products (2)

mRNA	Protein	Name
NM_002876.4	NP_002867.1	DNA repair protein RAD51 homolog 3 isoform 2
NM_058216.3	NP_478123.1	DNA repair protein RAD51 homolog 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
contributes to crossover junction DNA endonuclease activity	IMP IMP: Inferred from mutant phenotype	14716019	GOA
contributes to four-way junction DNA binding	IDA IDA: Inferred from direct assay	20207730	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9469824	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in DNA recombination	IDA IDA: Inferred from direct assay	19451272	GOA
involved in DNA repair	IDA IDA: Inferred from direct assay	19451272	GOA
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	23149936	GOA
involved in positive regulation of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	23108668	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of Rad51B-Rad51C-Rad51D-XRCC2 complex	IDA IDA: Inferred from direct assay	11751635	GOA
part of Rad51C-XRCC3 complex	IDA IDA: Inferred from direct assay	11751635	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16215984	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	20413593	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12966089	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16215984	GOA
located in replication fork	IDA IDA: Inferred from direct assay	20207730	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAD51C Protein Structure

Rad51

0
100
200
300
376 a.a.

Protein Preferred Names	Protein Names
DNA repair protein RAD51 homolog 3	RAD51-like protein 2

RAD51C Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	RAD51C	O43502	RAD51D	Homo sapiens	O75771	Pull Down	24141787
Intra	RAD51C	O43502	RAD51D	Homo sapiens	O75771	Pull Down	11751635
Intra	RAD51C	O43502	PALB2	Homo sapiens	Q86YC2	Pull Down	24141787
Intra	RAD51C	O43502	PALB2	Homo sapiens	Q86YC2	Anti Tag CoIP	24141787
Intra	RAD51C	O43502	PALB2	Homo sapiens	Q86YC2	Immunodepletion CoIP	24141787
Intra	RAD51C	O43502	RAD51B	Homo sapiens	O15315	Pull Down	11751635
Intra	RAD51C	O43502	RAD51B	Homo sapiens	O15315	Anti Bait CoIP	11842113
Intra	RAD51C	O43502	RAD51B	Homo sapiens	O15315	Anti Tag CoIP	34591612
Intra	RAD51C	O43502	RAD51B	Homo sapiens	O15315	Y2H	28864920
Intra	RAD51C	O43502	RAD51B	Homo sapiens	O15315	Pull Down	24141787
Intra	RAD51C	O43502	XRCC3	Homo sapiens	O43542	Y2H	28864920
Intra	RAD51C	O43502	XRCC3	Homo sapiens	O43542	Electrophoresis	11751635
Intra	RAD51C	O43502	XRCC3	Homo sapiens	O43542	GMS	11751635
Intra	RAD51C	O43502	XRCC3	Homo sapiens	O43542	Pull Down	24141787
Intra	RAD51C	O43502	XRCC3	Homo sapiens	O43542	Anti Tag CoIP	34591612
Intra	RAD51C	O43502	XRCC3	Homo sapiens	O43542	Anti Bait CoIP	24005329
Intra	RAD51C	O43502	RAD51	Homo sapiens	Q06609	Pull Down	24141787
Intra	RAD51C	O43502	RAD51	Homo sapiens	Q06609	Immunodepletion CoIP	24141787
Intra	RAD51C	O43502	RAD51	Homo sapiens	Q06609	Anti Bait CoIP	16395335
Intra	RAD51C	O43502	RAD51	Homo sapiens	Q06609	Anti Tag CoIP	24141787
Intra	RAD51C	O43502	XRCC2	Homo sapiens	O43543	Pull Down	24141787
Intra	RAD51C	O43502	SWSAP1	Homo sapiens	Q6NVH7	Anti Tag CoIP	21965664
Intra	RAD51C	O43502	SWSAP1	Homo sapiens	Q6NVH7	Pull Down	21965664

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Breast-Ovarian Cancer, Familial 3	Breast-Ovarian Cancer, Familial, Susceptibility To, 3 BROVCA3 Breast-Ovarian Cancer, Familial, 3 Breast Cancer Familial 3 Ovarian Cancer Familial 3 Cancer, Breast-Ovarian, Familial, Susceptibility To, Type 3
Fanconi Anemia, Complementation Group O	Fanconi Anemia Complementation Group O FANCO
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Hereditary Site-Specific Ovarian Cancer Syndrome
Ovarian Cancer 1	Ovarian Cancer, Susceptibility To Ovarian Cancer, Susceptibility To, 1 OVCAS1 Ovarian Cancer Ovarian Carcinoma Malignant Neoplasm Of Ovary Epithelial Ovarian Cancer
Breast-Ovarian Cancer, Familial 1	BROVCA1 Breast-Ovarian Cancer, Familial, Susceptibility To, 1 Breast-Ovarian Cancer, Familial, 1 Brca2 Hereditary Breast And Ovarian Cancer Syndrome Hboc1 Brca1 Hereditary Breast And Ovarian Cancer Syndrome Familial Susceptibility To Breast-Ovarian Cancer 1 Brovca2 Familial Susceptibility To Breast-Ovarian Cancer 2 Hboc Breast Cancer Familial 1 Ovarian Cancer Familial 1 Cancer, Breast-Ovarian, Familial, Susceptibility To, Type 1
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Inherited Cancer-Predisposing Syndrome	Hereditary Cancer-Predisposing Syndrome
Bap1 Tumor Predisposition Syndrome	Bap1-Related Tumor Predisposition Syndrome Common Syndrome Bap1 Cancer Syndrome Bap1-Tpds Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms Tumor Predisposition Syndrome Tumor Susceptibility Linked To Germline Bap1 Mutations Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms Tumor Predisposition
Familial Ovarian Cancer	Familial Ovarian Carcinoma Familial Ovarian Malignant Tumor
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Fallopian Tube Carcinoma	Fallopian Tube Cancer Cancer Of The Fallopian Tube Carcinoma Of Fallopian Tube Neoplasm Of Fallopian Tube Fallopian Tube Neoplasms Fallopian Tube Ca Fallopian Tube Neoplasm Malignant Neoplasm Of Uterine Tube Malignant Tumor Of Fallopian Tube Malignant Tumour Of Fallopian Tube Tumor Of The Fallopian Tube Tumor, Fallopian Tube, Malignant Malignant Tumor Of Fallopian Tubes Cancer Of Fallopian Tubes Malignant Tubal Tumor Tubal Cancer Malignant Neoplasm Of Fallopian Tube Primary Malignant Neoplasm Of Fallopian Tube Cancer Of The Oviduct
Mulibrey Nanism	MUL Muscle-Liver-Brain-Eye Nanism Pericardial Constriction And Growth Failure Perheentupa Syndrome Mulibrey Growth Disorder Mulibrey Nanism Syndrome Pericardial Constriction With Growth Failure Nanism Mulibrey
Diffuse Gastric And Lobular Breast Cancer Syndrome	Hereditary Diffuse Gastric Cancer HDGC LBC Familial Diffuse Gastric Cancer Fdgc Hereditary Diffuse Gastric Adenocarcinoma Breast Cancer, Lobular Gastric Cancer, Familial Diffuse, And Cleft Lip With Or Without Cleft Palate DGLBC Gastric Cancer, Hereditary Diffuse Gastric Cancer, Familial Diffuse Breast Cancer, Lobular Diffuse Gastric And Lobular Breast Cancer Syndrome With Or Without Cleft Lip And/Or Palate E-Cadherin-Associated Hereditary Gastric Cancer Familial Diffuse Cancer Of Stomach Hereditary Diffuse Cancer Of Stomach Gastric Cancer Familial Diffuse Gastric Cancer Familial Diffuse And Cleft Lip With Or Without Cleft Palate Cancer, Gastric, Hereditary Diffuse
Diffuse Gastric Cancer	Hereditary Diffuse Gastric Adenocarcinoma Hereditary Diffuse Gastric Cancer Signet Cell Adenocarcinoma Signet Ring Cell Carcinoma Signet Ring Cell Gastric Carcinoma Signet Ring Gastric Carcinoma Fdgc Familial Diffuse Cancer Of Stomach Familial Diffuse Gastric Cancer Gastric Cancer, Familial Diffuse Gastric Cancer, Hereditary Diffuse Hdgc Hereditary Diffuse Cancer Of Stomach Diffuse Gastric Cancer Syndrome Cancer, Gastric, Diffuse Carcinoma, Signet Ring Cell Gastric Signet Ring Carcinoma
Fanconi Anemia, Complementation Group D1	Fanconi Anemia Complementation Group D1 FANCD1 Fad1 Inherited Cancer-Predisposing Syndrome Due To Biallelic Brca2 Mutations
Fallopian Tube Disease	Fallopian Tube Diseases
Rete Ovarii Adenocarcinoma	Adenocarcinoma Of Rete Ovarii
Bilateral Breast Cancer	Bilateral Breast Carcinoma
Cervix Melanoma
Peritoneum Cancer	Peritoneal Neoplasm Cancer Of Peritoneum Malignant Tumor Of Peritoneum Peritoneal Neoplasms
Fanconi-Like Syndrome	Fanconi Like Syndrome
Sporadic Breast Cancer	Sporadic Breast Carcinoma
Mirror Movements 1	Congenital Mirror Movement Disorder Bimanual Synergia Congenital Mirror Movements Familial Congenital Controlateral Synkinesia Familial Congenital Mirror Movements Hereditary Congenital Controlateral Synkinesia Hereditary Congenital Mirror Movements Isolated Congenital Controlateral Synkinesia Isolated Congenital Mirror Movements Mirror Movements MRMV1 Mirror Movements 1 And/Or Agenesis Of The Corpus Callosum Mirror Movements, Congenital Bimanual Synkinesis Cmm Mirror Movements, Type 1
Fallopian Tube Endometrioid Adenocarcinoma	Endometrioid Carcinoma Of The Fallopian Tube Fallopian Tube Endometrioid Cancer Fallopian Tube Endometrioid Neoplasm Fallopian Tube Endometrioid Tumor
Lynch Syndrome	Hereditary Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Carcinoma Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hnpcc Coca 1 Hereditary Defective Mismatch Repair Syndrome Hereditary Non-Polyposis Colon Cancer Hereditary Non-Polyposis Colon Cancer Syndrome Hereditary Non-Polyposis Colorectal Cancer Hereditary Non-Polyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colon Cancer Syndrome Hereditary Nonpolyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colorectal Neoplasm Hnpcc - Hereditary Nonpolyposis Colon Cancer Cancer Family Syndrome Familial Nonpolyposis Colorectal Cancer Colon Cancer, Familial Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cancer, Colorectal, Nonpolyposis, Hereditary Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Li-Fraumeni Syndrome	Sarcoma Family Syndrome Of Li And Fraumeni Sbla Syndrome LFS Li-Fraumeni Familiar Cancer Susceptibility Syndrome Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome Lfs1 Li Fraumeni Syndrome Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome Lfl Sbla Syndrome Li-Fraumeni-Like Syndrome Li-Fraumeni Syndrome 1
Serous Cystadenocarcinoma	Serous Adenocarcinoma Cystadenocarcinoma, Serous Serous Carcinoma Cystadenocarcinoma Serous
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Nijmegen Breakage Syndrome	Berlin Breakage Syndrome NBS Microcephaly, Normal Intelligence And Immunodeficiency Ataxia-Telangiectasia Variant Ataxia-Telangiectasia Variant V1 Seemanova Syndrome Ii Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome Seemanova Syndrome Type 2 At-V1 Microcephaly With Normal Intelligence, Immunodeficiency, And Lymphoreticular Malignancies Nonsyndromal Microcephaly, Autosomal Recessive, With Normal Intelligence Immunodeficiency, Microcephaly, And Chromosomal Instability Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome Microcephaly Immunodeficiency Lymphoreticuloma Microcephaly With Normal Intelligence Immunodeficiency And Lymphoreticular Malignancies Nonsyndromal Microcephaly Autosomal Recessive With Normal Intelligence Seemanova Syndrome 2 Ataxia-Telangiectasia Variant 1 Seemanova Syndrome At V1 Ataxia-Telangiectasia, Variant 1 Microcephaly-Immunodeficiency-Lymphoid Malignancy Syndrome V-At Ataxia Telangiectasia Variant V1
Physical Disorder	Physical Illness

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS11608	RAD51C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RAD51C	VGNC	VGNC:33686
Macaca mulatta	RAD51C	VGNC	VGNC:76646
Canis familiaris	RAD51C	VGNC	VGNC:45319
Rattus norvegicus	RAD51C	RGD	RGD:1563765
Felis catus	RAD51C	VGNC	VGNC:69216
Mus musculus	RAD51C	MGD	MGI:2150020
Others	RAD51C	NCBI