RAD51B - RAD51 paralog B Gene

Also Known as REC2; R51H2; RAD51L1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5890

About RAD51B

Cytogenetic location: 14q24.1 Genomic coordinates (GRCh38): 14:67,819,779-68,683,096 (from NCBI)

This gene has 24 transcripts (splice variants), 151 orthologues, 6 paralogues and is associated with 77 phenotypes. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the Other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell Apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016]

RAD51B Products (12)

mRNA	Protein	Name
NM_001321809.2	NP_001308738.1	DNA repair protein RAD51 homolog 2 isoform 4
NM_001321810.2	NP_001308739.1	DNA repair protein RAD51 homolog 2 isoform 4
NM_001321812.1	NP_001308741.1	DNA repair protein RAD51 homolog 2 isoform 5
NM_001321814.2	NP_001308743.1	DNA repair protein RAD51 homolog 2 isoform 5
NM_001321815.1	NP_001308744.1	DNA repair protein RAD51 homolog 2 isoform 6
NM_001321817.2	NP_001308746.1	DNA repair protein RAD51 homolog 2 isoform 10
NM_001321818.2	NP_001308747.1	DNA repair protein RAD51 homolog 2 isoform 7
NM_001321819.1	NP_001308748.1	DNA repair protein RAD51 homolog 2 isoform 8
NM_001321821.2	NP_001308750.1	DNA repair protein RAD51 homolog 2 isoform 9
NM_002877.6	NP_002868.1	DNA repair protein RAD51 homolog 2 isoform 1
NM_133509.5	NP_598193.2	DNA repair protein RAD51 homolog 2 isoform 3
NM_133510.4	NP_598194.1	DNA repair protein RAD51 homolog 2 isoform 2

RAD51B Protein Structure

Rad51

0
100
200
300
384 a.a.

Protein Preferred Names	Protein Names
DNA repair protein RAD51 homolog 2	RAD51 homolog B

RAD51B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAD51B	O15315	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	RAD51B	O15315	RAD51D	Homo sapiens	O75771	Anti Tag CoIP	33961781
Intra	RAD51B	O15315	RAD51D	Homo sapiens	O75771	Electrophoresis	11751635
Intra	RAD51B	O15315	RAD51D	Homo sapiens	O75771	GMS	11751635
Intra	RAD51B	O15315	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	RAD51B	O15315	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	RAD51B	O15315	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	RAD51B	O15315	RAD51C	Homo sapiens	O43502	Anti Tag CoIP	33961781
Intra	RAD51B	O15315	RAD51C	Homo sapiens	O43502	GMS	11751635
Intra	RAD51B	O15315	RAD51C	Homo sapiens	O43502	Y2H	9469824
Intra	RAD51B	O15315	RAD51C	Homo sapiens	O43502	Anti Bait CoIP	11842113
Intra	RAD51B	O15315	RAD51C	Homo sapiens	O43502	Electrophoresis	11751635
Intra	RAD51B	O15315	RPAIN	Homo sapiens	Q86UA6	Y2H Array	32296183
Intra	RAD51B	O15315	RPAIN	Homo sapiens	Q86UA6	Y2H Prey Pooling	32296183
Intra	RAD51B	O15315	RPAIN	Homo sapiens	Q86UA6	Validated Y2H	32296183
Intra	RAD51B	O15315	SWSAP1	Homo sapiens	Q6NVH7	Anti Tag CoIP	21965664
Intra	RAD51B	O15315	SWSAP1	Homo sapiens	Q6NVH7	Pull Down	21965664

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Leiomyoma	Leiomyomatous Neoplasm Leiomyomatous Tumor Leiomyomas Fibroid Tumor Uterine Fibroids
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Alcoholic Psychosis	Psychoses, Alcoholic Alcoholic Psychoses
Leiomyoma, Uterine	Uterine Leiomyoma Uterine Fibroid Uterine Fibroids Plexiform Leiomyoma UL Leiomyoma Of Corpus Uteri Uterus Fibroma
Alcohol-Induced Mental Disorder	Psychoses, Alcoholic
Rectum Squamous Cell Carcinoma	Squamous Cell Carcinoma Of The Rectum Rectal Squamous Cell Carcinoma Squamous Carcinoma Of Rectum
Macular Degeneration, Age-Related, 1	Macular Degeneration Age-Related Macular Degeneration Macular Degeneration, Age-Related Age Related Macular Degeneration Age Related Macular Degeneration 1 ARMD1 Senile Macular Degeneration Maculopathy, Age-Related, 1 Macular Degeneration, Age-Related, Reduced Risk Of Age Related Maculopathy 1 Age Related Maculopathies Age Related Maculopathy Senile Macular Retinal Degeneration Macular Degeneration Of Retina Age-Related Maculopathy Amd Armd Age-Related Maculopathy, Susceptibility To Maculopathy Age-Related Macular Degeneration, Age-Related, 1, Susceptibility To Maculopathy, Age-Related Macular Degeneration, Age-Related, Type 1 Macular Degeneration, Age-Related, 2
Cervix Melanoma
Plantar Fascial Fibromatosis	Dupuytren'S Contracture Of Foot Ledderhose'S Disease Fibromatosis, Plantar Ledderhose Disease
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Uterine Benign Neoplasm
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11607	RAD51B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RAD51B	VGNC	VGNC:76647
Felis catus	RAD51B	VGNC	VGNC:80873
Mus musculus	RAD51B	MGD	MGI:1099436
Bos taurus	RAD51B	VGNC	VGNC:33685
Rattus norvegicus	RAD51B	RGD	RGD:1560681
Canis familiaris	RAD51B	VGNC	VGNC:82294
Others	RAD51B	NCBI