XRCC2 - X-ray repair cross complementing 2 Gene

Also Known as FANCU; POF17; SPGF50

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7516

About XRCC2

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:152,644,776-152,676,141 (from NCBI)

This gene has 4 transcripts (splice variants), 191 orthologues, 6 paralogues and is associated with 6 phenotypes. Broad expression in testis (RPKM 1.4), bone marrow (RPKM 1.0) and 22 other tissues.

Summary

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008]

XRCC2 Products (1)

mRNA	Protein	Name
NM_005431.2	NP_005422.1	DNA repair protein XRCC2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to four-way junction DNA binding	IDA IDA: Inferred from direct assay	20207730	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10749867	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA repair	IGI IGI: Inferred from genetic interaction	10422536	GOA
involved in DNA strand invasion	IDA IDA: Inferred from direct assay	11834724	GOA
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	21276791	GOA
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	23149936	GOA
involved in mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	21276791	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Rad51B-Rad51C-Rad51D-XRCC2 complex	IDA IDA: Inferred from direct assay	11751635	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21276791	GOA
located in replication fork	IDA IDA: Inferred from direct assay	20207730	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XRCC2 Protein Structure

Rad51

0
100
200
280 a.a.

Protein Preferred Names	Protein Names
DNA repair protein XRCC2	X-ray repair complementing defective repair in Chinese hamster cells 2

XRCC2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	XRCC2	O43543	RAD51C	Homo sapiens	O43502	Anti Tag CoIP	28514442
Intra	XRCC2	O43543	RAD51C	Homo sapiens	O43502	Anti Bait CoIP	11842113
Intra	XRCC2	O43543	RAD51C	Homo sapiens	O43502	Anti Tag CoIP	33961781
Intra	XRCC2	O43543	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	XRCC2	O43543	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

XRCC2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810940	XRCC2 Antibody	WB, IHC-P, ICC/IF	Human, Monkey

Related Diseases

Diseases	Alias
Premature Ovarian Failure 17	POF17 Ovarian Failure, Premature, Type 17
Spermatogenic Failure 50	SPGF50
Fanconi Anemia, Complementation Group U	Fanconi Anemia Complementation Group U FANCU
Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Inherited Cancer-Predisposing Syndrome	Hereditary Cancer-Predisposing Syndrome
Bap1 Tumor Predisposition Syndrome	Bap1-Related Tumor Predisposition Syndrome Common Syndrome Bap1 Cancer Syndrome Bap1-Tpds Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms Tumor Predisposition Syndrome Tumor Susceptibility Linked To Germline Bap1 Mutations Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms Tumor Predisposition
Short Stature, Microcephaly, And Endocrine Dysfunction	SSMED
Hereditary Breast Cancer	Familial Breast Cancer Familial Breast Carcinoma Hereditary Breast Carcinoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Cervix Melanoma
Infertility
Lipodystrophy, Familial Partial, Type 6	FPLD6 Lipe-Related Familial Partial Lipodystrophy Familial Partial Lipodystrophy Type 6 Lipe-Related Fpld Lipodystrophy, Familial Partial, Associated With Lipe Mutations Familial Partial Lipodystrophy Associated With Lipe Mutations Lipodystrophy, Familial Partial, 6
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Lynch Syndrome	Hereditary Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Carcinoma Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hnpcc Coca 1 Hereditary Defective Mismatch Repair Syndrome Hereditary Non-Polyposis Colon Cancer Hereditary Non-Polyposis Colon Cancer Syndrome Hereditary Non-Polyposis Colorectal Cancer Hereditary Non-Polyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colon Cancer Syndrome Hereditary Nonpolyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colorectal Neoplasm Hnpcc - Hereditary Nonpolyposis Colon Cancer Cancer Family Syndrome Familial Nonpolyposis Colorectal Cancer Colon Cancer, Familial Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cancer, Colorectal, Nonpolyposis, Hereditary Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15897	XRCC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	XRCC2	VGNC	VGNC:48466
Mus musculus	XRCC2	MGD	MGI:1927345
Felis catus	XRCC2	VGNC	VGNC:67117
Macaca mulatta	XRCC2	VGNC	VGNC:78813
Bos taurus	XRCC2	VGNC	VGNC:37003
Rattus norvegicus	XRCC2	RGD	RGD:1564823
Others	XRCC2	NCBI