1. Cell Cycle/DNA Damage
  2. RAD51
  3. IBR2

IBR2 

Cat. No.: HY-103710 Purity: 98.14%
Handling Instructions

IBR2 is a specific RAD51 inhibitor.

For research use only. We do not sell to patients.

IBR2 Chemical Structure

IBR2 Chemical Structure

CAS No. : 313526-24-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
50 mg USD 520 In-stock
Estimated Time of Arrival: December 31
100 mg USD 910 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

IBR2 is a specific RAD51 inhibitor.

IC50 & Target

RAD51[1]

In Vitro

IBR2 shows interesting RAD51 inhibition activities. RAD51 is rapidly degraded in IBR2-treated cancer cells, and the homologous recombination repair is impaired, subsequently leading to cell death. The IC50 values of the original IBR2 are in the range of 12-20 µM for most tested cancer cell lines. IBR2 can inhibit the growth of triple-negative human breast cancer cell line MBA-MD-468 with an IC50 of 14.8 µM[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 150 mg/mL (374.54 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4969 mL 12.4847 mL 24.9694 mL
5 mM 0.4994 mL 2.4969 mL 4.9939 mL
10 mM 0.2497 mL 1.2485 mL 2.4969 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

Human breast cancer cell lines MCF7, MDA-MB-231, MDA-MB-361, MDA-MB-435, MDA-MB468, Hs578-T, human osteosarcoma cell line U20S, human glioblastoma cell line T98G and human cervical adenocarcinoma cell line HeLa are used. Standard XTT assays with a four-day drug treatment procedure are performed to measure the dose dependent cytotoxicity of IBR analogs in cultured cells. In brief, cells are plated on 96-well dishes one day before the drug treatment, followed by drug (e.g., IBR2) treatment on day 2 and XTT assay on day 6 after drug addition by using a commercial cell proliferation kit . Triplicate sets are measured and compiled for final data presentation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

400.49

Formula

C₂₄H₂₀N₂O₂S

CAS No.

313526-24-8

SMILES

O=S(N1C(C2=CNC3=C2C=CC=C3)C4=C(C=CC=C4)C=C1)(CC5=CC=CC=C5)=O

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
IBR2
Cat. No.:
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IBR2

Cat. No.: HY-103710