BRCA2 - BRCA2 DNA repair associated Gene

Also Known as FAD; FACD; FAD1; GLM3; BRCC2; FANCD; PNCA2; FANCD1; XRCC11; BROVCA2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 675

About BRCA2

Cytogenetic location: 13q13.1 Genomic coordinates (GRCh38): 13:32,315,508-32,400,268 (from NCBI)

This gene has 15 transcripts (splice variants), 174 orthologues and is associated with 182 phenotypes. Broad expression in bone marrow (RPKM 2.9), testis (RPKM 2.2) and 17 other tissues.

Summary

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian Cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The largest exon in both genes is exon 11, which harbors the most important and frequent mutations in breast Cancer patients. The BRCA2 gene was found on chromosome 13q12.3 in human. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, May 2020]

BRCA2 Products (5)

mRNA	Protein	Name
NM_000059.4	NP_000050.3	breast cancer type 2 susceptibility protein isoform 1
NM_001406719.1	NP_001393648.1	breast cancer type 2 susceptibility protein isoform 3
NM_001406720.1	NP_001393649.1	breast cancer type 2 susceptibility protein isoform 2
NM_001406721.1	NP_001393650.1	breast cancer type 2 susceptibility protein isoform 4
NM_001406722.1	NP_001393651.1	breast cancer type 2 susceptibility protein isoform 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables gamma-tubulin binding	IPI IPI: Inferred from physical interaction	17286961	GOA
enables histone H3 acetyltransferase activity	IDA IDA: Inferred from direct assay	9619837	GOA
enables histone H4 acetyltransferase activity	IDA IDA: Inferred from direct assay	9619837	GOA
NOT enables histone acetyltransferase activity	IDA IDA: Inferred from direct assay	9824164	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21601571	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	15314155	GOA
enables protein binding	IDA IDA: Inferred from direct assay	9774970	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9560268	GOA
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	20729832	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to ionizing radiation	IMP IMP: Inferred from mutant phenotype	14636569	GOA
involved in centrosome duplication	IMP IMP: Inferred from mutant phenotype	17286961	GOA
involved in double-strand break repair	IMP IMP: Inferred from mutant phenotype	16845393	GOA
involved in double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	20729832	GOA
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	21719596	GOA
involved in establishment of protein localization to telomere	IDA IDA: Inferred from direct assay	21076401	GOA
involved in mitotic recombination-dependent replication fork processing	IMP IMP: Inferred from mutant phenotype	21076401	GOA
involved in negative regulation of mammary gland epithelial cell proliferation	IDA IDA: Inferred from direct assay	15930293	GOA
involved in nucleotide-excision repair	IMP IMP: Inferred from mutant phenotype	16845393	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9126734	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of BRCA2-MAGE-D1 complex	IDA IDA: Inferred from direct assay	15930293	GOA
part of DNA repair complex	IPI IPI: Inferred from physical interaction	19369211	GOA
located in centrosome	IDA IDA: Inferred from direct assay	17286961	GOA
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	21076401	GOA
located in lateral element	IDA IDA: Inferred from direct assay	9774970	GOA
part of nuclear ubiquitin ligase complex	IDA IDA: Inferred from direct assay	14636569	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9560268	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	9774970	GOA
located in secretory granule	IDA IDA: Inferred from direct assay	8589722	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRCA2 Protein Structure

BRCA2

BRCA-2_helical

BRCA-2_OB1

Tower

BRCA-2_OB3

0
600
1200
1800
2400
3000
3418 a.a.

Protein Preferred Names	Protein Names
breast cancer type 2 susceptibility protein	BRCA1/BRCA2-containing complex, subunit 2

BRCA2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BRCA2	P51587	PDS5B	Homo sapiens	Q9NTI5	Anti Bait CoIP	22293751
Intra	BRCA2	P51587	PDS5B	Homo sapiens	Q9NTI5	Y2H	22293751
Intra	BRCA2	P51587	PDS5B	Homo sapiens	Q9NTI5	Anti Tag CoIP	22293751
Intra	BRCA2	P51587	PALB2	Homo sapiens	Q86YC2	Anti Tag CoIP	19369211
Intra	BRCA2	P51587	PALB2	Homo sapiens	Q86YC2	Anti Tag CoIP	22293751
Intra	BRCA2	P51587	PALB2	Homo sapiens	Q86YC2	Anti Bait CoIP	19609323
Intra	BRCA2	P51587	PALB2	Homo sapiens	Q86YC2	IF	24485656
Intra	BRCA2	P51587	PALB2	Homo sapiens	Q86YC2	Pull Down	24141787
Intra	BRCA2	P51587	PALB2	Homo sapiens	Q86YC2	Anti Bait CoIP	22293751
Intra	BRCA2	P51587	PALB2	Homo sapiens	Q86YC2	BiFC	30410870
Intra	BRCA2	P51587	PALB2	Homo sapiens	Q86YC2	Pull Down	30410870
Intra	BRCA2	P51587	PALB2	Homo sapiens	Q86YC2	Anti Bait CoIP	19369211
Intra	BRCA2	P51587	PALB2	Homo sapiens	Q86YC2	X-Ray Diffraction	19609323
Intra	BRCA2	P51587	PALB2	Homo sapiens	Q86YC2	TAP	19369211
Intra	BRCA2	P51587	RAD51	Homo sapiens	Q06609-1	Crosslink	17515903
Intra	BRCA2	P51587	RAD51	Homo sapiens	Q06609-1	Pull Down	17515903
Intra	BRCA2	P51587	RAD51	Homo sapiens	Q06609-1	GMS	17515903
Intra	BRCA2	P51587	RAD51	Homo sapiens	Q06609-1	Comig Non-Denat Gel	17515903
Intra	BRCA2	P51587	POLH	Homo sapiens	Q9Y253	Anti Bait CoIP	24485656
Intra	BRCA2	P51587	POLH	Homo sapiens	Q9Y253	Pull Down	24485656
Intra	BRCA2	P51587	POLH	Homo sapiens	Q9Y253	Anti Tag CoIP	24485656
Intra	BRCA2	P51587	POLH	Homo sapiens	Q9Y253	IF	24485656
Intra	BRCA2	P51587	RAD51	Homo sapiens	Q06609	Anti Tag CoIP	22293751
Intra	BRCA2	P51587	RAD51	Homo sapiens	Q06609	X-Ray Diffraction	12442171
Intra	BRCA2	P51587	RAD51	Homo sapiens	Q06609	Anti Tag CoIP	15800615
Intra	BRCA2	P51587	RAD51	Homo sapiens	Q06609	Anti Bait CoIP	22293751
Intra	BRCA2	P51587	RAD51	Homo sapiens	Q06609	Anti Bait CoIP	21399666
Intra	BRCA2	P51587	RAD51	Homo sapiens	Q06609	Y2H	17541404
Intra	BRCA2	P51587	RAD51	Homo sapiens	Q06609	Pull Down	20729832
Intra	BRCA2	P51587	RAD51	Homo sapiens	Q06609	Anti Bait CoIP	17541404
Intra	BRCA2	P51587	RAD51	Homo sapiens	Q06609	Competition Binding	21601571
Intra	BRCA2	P51587	RAD51	Homo sapiens	Q06609	Y2H	10551859
Intra	BRCA2	P51587	RAD51	Homo sapiens	Q06609	CoIP	10551859
Intra	BRCA2	P51587	RAD51	Homo sapiens	Q06609	Y2H	9560268
Intra	BRCA2	P51587	RAD51	Homo sapiens	Q06609	Anti Bait CoIP	18264088
Intra	BRCA2	P51587	RAD51	Homo sapiens	Q06609	Pull Down	15800615
Intra	BRCA2	P51587	FANCD2	Homo sapiens	Q9BXW9	Anti Bait CoIP	18212739
Intra	BRCA2	P51587	FANCD2	Homo sapiens	Q9BXW9	Affinity Chrom	15115758
Intra	BRCA2	P51587	TP53	Homo sapiens	P04637	NMR	20421506
Intra	BRCA2	P51587	TP53	Homo sapiens	P04637	ITC	20421506
Intra	BRCA2	P51587	TP53	Homo sapiens	P04637	Fluorescence Spectr	20421506
Intra	BRCA2	P51587	TP53	Homo sapiens	P04637	Pull Down	20421506
Intra	BRCA2	P51587	FANCD2	Homo sapiens	Q9BXW9-2	Anti Bait CoIP	18212739
Intra	BRCA2	P51587	HMG20B	Homo sapiens	Q9P0W2	Anti Bait CoIP	21399666
Intra	BRCA2	P51587	HMG20B	Homo sapiens	Q9P0W2	Pull Down	21399666
Intra	BRCA2	P51587	SEM1	Homo sapiens	P60896	CoIP	10373512
Intra	BRCA2	P51587	SEM1	Homo sapiens	P60896	Anti Bait CoIP	24013206
Intra	BRCA2	P51587	SEM1	Homo sapiens	P60896	Anti Bait CoIP	16205630
Intra	BRCA2	P51587	SEM1	Homo sapiens	P60896	Anti Tag CoIP	16205630
Intra	BRCA2	P51587	SEM1	Homo sapiens	P60896	FRET	24013206
Intra	BRCA2	P51587	SEM1	Homo sapiens	P60896	Y2H	22293751
Intra	BRCA2	P51587	DMC1	Homo sapiens	Q14565	Anti Bait CoIP	17541404
Intra	BRCA2	P51587	DMC1	Homo sapiens	Q14565	Peptide Array	17541404
Intra	BRCA2	P51587	DMC1	Homo sapiens	Q14565	Pull Down	20729832
Intra	BRCA2	P51587	DMC1	Homo sapiens	Q14565	Filter Binding	17541404

Cross: Cross-species interaction Intra: Intraspecies interaction

BRCA2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86790	BRCA2 Antibody (YA6483)	WB, FC	Human

Related Diseases

Diseases	Alias
Fanconi Anemia, Complementation Group D1	Fanconi Anemia Complementation Group D1 FANCD1 Fad1 Inherited Cancer-Predisposing Syndrome Due To Biallelic Brca2 Mutations
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Breast-Ovarian Cancer, Familial 2	Breast-Ovarian Cancer, Familial, Susceptibility To, 2 Breast-Ovarian Cancer, Familial, 2 BROVCA2 Hboc2 Breast Cancer Familial 2 Ovarian Cancer Familial 2 Cancer, Breast-Ovarian, Familial, Susceptibility To, Type 2
Pancreatic Cancer 2	Pancreatic Cancer, Susceptibility To, 2 PNCA2 Cancer, Pancreatic, Susceptibility To, Type 2
Glioma Susceptibility 3	GLM3 Glioblastoma 3 Glioma 3 Glioma, Susceptibility, Type 3
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Bilateral Breast Cancer	Bilateral Breast Carcinoma
Islet Cell Tumor	Pancreatic Neuroendocrine Tumor Neuroendocrine Tumor Of Pancreas Pnet Pancreatic Net Pancreatic Endocrine Tumor Well-Differentiated Nen Of Pancreas Well-Differentiated Neuroendocrine Neoplasm Of Pancreas Well-Differentiated Pancreatic Nen Well-Differentiated Pancreatic Neuroendocrine Neoplasm Endocrine Pancreas Cancer Islet Cell Neoplasm Islet Cell Tumour Malignant Pancreatic Endocrine Tumor Malignant Pancreatic Endocrine Tumour Malignant Tumor Of Endocrine Pancreas Malignant Tumour Of Endocrine Pancreas Pancreatic Endocrine Neoplasm Pancreatic Neuroendocrine Neoplasm Adenoma, Islet Cell Well Differentiated Pancreatic Endocrine Tumor Malignant Neoplasm Of Endocrine Pancreas Pancreatic Endocrine Carcinoma
Headache	Headache Disorder
Ovarian Cancer 1	Ovarian Cancer, Susceptibility To Ovarian Cancer, Susceptibility To, 1 OVCAS1 Ovarian Cancer Ovarian Carcinoma Malignant Neoplasm Of Ovary Epithelial Ovarian Cancer
Breast-Ovarian Cancer, Familial 1	BROVCA1 Breast-Ovarian Cancer, Familial, Susceptibility To, 1 Breast-Ovarian Cancer, Familial, 1 Brca2 Hereditary Breast And Ovarian Cancer Syndrome Hboc1 Brca1 Hereditary Breast And Ovarian Cancer Syndrome Familial Susceptibility To Breast-Ovarian Cancer 1 Brovca2 Familial Susceptibility To Breast-Ovarian Cancer 2 Hboc Breast Cancer Familial 1 Ovarian Cancer Familial 1 Cancer, Breast-Ovarian, Familial, Susceptibility To, Type 1
Chordoma	CHDM Notochordoma Notochordal Sarcoma Chordoma, Susceptibility To Chordocarcinoma Chordoepithelioma
Diffuse Midline Glioma, H3 K27m-Mutant	Diffuse Intrinsic Pontine Glioma Dipg Infiltrative Brainstem Glioma
Nephrolithiasis	Kidney Stones Stone - Kidney/Ureter Kidney Calculi
Tumor Predisposition Syndrome 1	TPDS1 Tumor Predisposition Syndrome TPDS
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Osseous Heteroplasia, Progressive	Progressive Osseous Heteroplasia POH Osteoma Cutis Familial Ectopic Ossification Ectopic Ossification Familial Type Ectopic Ossification Heterotopic Ossification Ectopic Ossification, Familial Cutaneous Ossification Myositis Ossificans Progressiva Osteodermia Osteosis Cutis Ossification Heterotopic Heteroplasia, Osseous, Progressive Fibrodysplasia Ossificans Progressiva
Tracheoesophageal Fistula With Or Without Esophageal Atresia	Esophageal Atresia With Or Without Tracheoesophageal Fistula Esophageal Atresia
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Isolated Growth Hormone Deficiency, Type Ia	Ighd Ia Primordial Dwarfism Isolated Growth Hormone Deficiency Type Ia Sexual Ateleiotic Dwarfism Pituitary Dwarfism I IGHD1A Illig-Type Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, Type Ia Congenital Ighd Type Ia Congenital Isolated Gh Deficiency Type Ia Congenital Isolated Growth Hormone Deficiency Type Ia Pituitary Dwarfism 1 Growth Hormone Deficiency, Isolated, Autosomal Recessive Autosomal Recessive Isolated Growth Hormone Deficiency Isolated Growth Hormone Deficiency Type 1a Congenital Ighd Congenital Isolated Gh Deficiency Congenital Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated Autosomal Recessive Illig Type Growth Hormone Deficiency Non-Acquired Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, 1a Growth Hormone Deficiency Isolated Autosomal Recessive Dwarfism, Primordial Dwarfism
Esophageal Atresia	Tracheoesophageal Fistula Congenital Atresia Of Esophagus Congenital Imperforate Esophagus Imperforate Esophagus Oesophageal Atresia Te Fistula Tef Tracheoesophageal Fistula With Or Without Esophageal Atresia
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Polydactyly	Non-Syndromic Polydactyly Polydactyly, Postaxial Postaxial Polydactyly Supernumerary Digit Extra Digits Hyperdactyly Polydactylia Polydactylism Supernumerary Digits
Bap1 Tumor Predisposition Syndrome	Bap1-Related Tumor Predisposition Syndrome Common Syndrome Bap1 Cancer Syndrome Bap1-Tpds Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms Tumor Predisposition Syndrome Tumor Susceptibility Linked To Germline Bap1 Mutations Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms Tumor Predisposition
Inherited Cancer-Predisposing Syndrome	Hereditary Cancer-Predisposing Syndrome
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Rhabdomyosarcoma
Genetic Non-Acquired Premature Ovarian Failure
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Cholangiocarcinoma	Cholangiocarcinoma, Susceptibility To Extrahepatic Cholangiocarcinoma Intrahepatic Cholangiocarcinoma Chlc Chlc, Susceptibility To Cc Cholangiocarcinoma Of Biliary Tract Cholangiocellular Carcinoma Distal Cholangiocarcinoma Perihilar Cholangiocarcinoma Bile Duct Cancer Cca Adult Primary Cholangiocellular Carcinoma Bile Duct Carcinoma
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hereditary Breast Cancer	Familial Breast Cancer Familial Breast Carcinoma Hereditary Breast Carcinoma
Fallopian Tube Carcinoma	Fallopian Tube Cancer Cancer Of The Fallopian Tube Carcinoma Of Fallopian Tube Neoplasm Of Fallopian Tube Fallopian Tube Neoplasms Fallopian Tube Ca Fallopian Tube Neoplasm Malignant Neoplasm Of Uterine Tube Malignant Tumor Of Fallopian Tube Malignant Tumour Of Fallopian Tube Tumor Of The Fallopian Tube Tumor, Fallopian Tube, Malignant Malignant Tumor Of Fallopian Tubes Cancer Of Fallopian Tubes Malignant Tubal Tumor Tubal Cancer Malignant Neoplasm Of Fallopian Tube Primary Malignant Neoplasm Of Fallopian Tube Cancer Of The Oviduct
Polyposis Syndrome, Hereditary Mixed, 1	HMPS1 Colorectal Adenoma And Carcinoma 1 Crac1 Colorectal Cancer 4 Chromosome 15q13-Q14 Duplication Syndrome, 40-Kb Colorectal Cancer, Susceptibility To, 4 Hereditary Mixed Polyposis Syndrome 1 Polyposis Syndrome, Hereditary Mixed 1 CRCS4 Susceptibility To Colorectal Cancer On Chromosome 15 Polyposis Syndrome, Mixed Hereditary 1 Adenomatous Polyps
Hereditary Site-Specific Ovarian Cancer Syndrome
Li-Fraumeni Syndrome	Sarcoma Family Syndrome Of Li And Fraumeni Sbla Syndrome LFS Li-Fraumeni Familiar Cancer Susceptibility Syndrome Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome Lfs1 Li Fraumeni Syndrome Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome Lfl Sbla Syndrome Li-Fraumeni-Like Syndrome Li-Fraumeni Syndrome 1
Hepatoblastoma
Fanconi Anemia, Complementation Group D2	Fanconi Anemia Complementation Group D2 FANCD2 Fad2 Fa4 Fancd Fanconi Pancytopenia Type 4 Fanconi Anemia, Complementation Group D Fanconi Pancytopenia, Type 4 Facd Fanconi Anemia Complementation Group D
Ocular Cancer	Eye Neoplasm Eye Carcinoma Eye Cancer Eye Neoplasms Malignant Eye Neoplasm Neoplasm Of Eye Neoplasm Of Eye Proper Ocular Tumor Carcinoma Of Eye Ocular Carcinoma Malignant Tumor Of Eye
Lynch Syndrome	Hereditary Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Carcinoma Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hnpcc Coca 1 Hereditary Defective Mismatch Repair Syndrome Hereditary Non-Polyposis Colon Cancer Hereditary Non-Polyposis Colon Cancer Syndrome Hereditary Non-Polyposis Colorectal Cancer Hereditary Non-Polyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colon Cancer Syndrome Hereditary Nonpolyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colorectal Neoplasm Hnpcc - Hereditary Nonpolyposis Colon Cancer Cancer Family Syndrome Familial Nonpolyposis Colorectal Cancer Colon Cancer, Familial Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cancer, Colorectal, Nonpolyposis, Hereditary Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Female Breast Cancer	Female Breast Carcinoma Carcinoma Of Female Breast Mammary Carcinoma Of Female Breast Malignant Neoplasm Of Female Breast
Bloom Syndrome	BLM Bs Bls Bloom-Torre-Machacek Syndrome Microcephaly, Growth Restriction, And Increased Sister Chromatid Exchange 1 Mgrisce1 Congenital Telangiectatic Erythema Congenital Telangiectatic Erythema Syndrome Growth Deficiency, Sun-Sensitive, Telangiectatic, Hypo And Hyperpigmented Skin, Predisposition To Malignancy And Chromosomal Instability Bloom'S Syndrome Bsyn
Fanconi Anemia, Complementation Group F	Fanconi Anemia Complementation Group F FANCF
Ataxia-Telangiectasia	Ataxia Telangiectasia Louis-Bar Syndrome AT At1 Ataxia-Telangiectasia Syndrome Ataxia - Telangiectasia Variant Boder-Sedgwick Syndrome Louis Bar Syndrome Cerebello-Oculocutaneous Telangiectasia Immunodeficiency With Ataxia Telangiectasia A-T Ataxia Telangiectasia Syndrome Atm Telangiectasia, Cerebello-Oculocutaneous Ataxia-Telangiectasia Variant
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Pancreatic Adenocarcinoma	Adenocarcinoma Of The Pancreas Adenocarcinoma Of Pancreas Pancreas Adenocarcinoma Malignant Exocrine Neoplasm Primary Pancreatic Adenocarcinoma Adenocarcinoma Of Islet Cell Of Pancreas Islet Cell Adenocarcinoma Of Unspecified Site Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Tetraploidy	Tetraploidy Syndrome
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed
Acinar Cell Carcinoma	Acinic Cell Carcinoma Acinic Cell Tumor Carcinoma Acinar Cell Carcinoma, Acinar Cell Acinar Cell Tumor
Ocular Melanoma	Intraocular Melanoma Uveal Melanoma Eye Melanoma Melanoma Of Eye Melanoma Of The Uvea Malignant Melanoma Of Eye
Fallopian Tube Disease	Fallopian Tube Diseases
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple
Sporadic Breast Cancer	Sporadic Breast Carcinoma
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Peutz-Jeghers Syndrome	PJS Polyposis, Hamartomatous Intestinal Polyps-And-Spots Syndrome Lentiginosis, Perioral Periorificial Lentiginosis Syndrome Hamartomatous Intestinal Polyposis Hamartomatous Polyp Colonic Hamartomatous Polyp Gastric Peutz-Jeghers Polyp Peutz Jeghers Colon Polyp Peutz Jeghers Polyp Peutz-Jeghers Polyp Of Small Intestine Peutz-Jeghers Small Bowel Hamartoma Peutz Jeghers Polyposis Intestinal Polyposis-Cutaneous Pigmentation Syndrome Peutz-Jeghers Polyposis Polyposis, Intestinal, Ii Intestinal Hamartomatous Polyposis Peutz-Jeghers Polyp Peutz-Jeghers Polyp Of The Stomach Peutz Jehgers Polyp Peutz-Jeghers Polyps Of Small Bowel
Bile Duct Cancer	Bile Duct Carcinoma Extrahepatic Bile Duct Carcinoma Carcinoma Of Extrahepatic Bile Duct Extrahepatic Bile Duct Cancer Bile Duct Neoplasms Bile Duct Tumor Ca Extrahepatic Bile Ducts Malignant Neoplasm Of The Extrahepatic Bile Duct Bile Duct Extrahepatic Carcinoma Malignant Tumor Of Extrahepatic Bile Duct
Breast Carcinoma In Situ	Carcinoma In Situ Of Breast Non-Infiltrating Carcinoma Of Breast Breast Cancer In Situ
Cowden Syndrome 1	Bannayan-Riley-Ruvalcaba Syndrome Pten Hamartoma Tumor Syndrome Lhermitte-Duclos Disease Bannayan-Zonana Syndrome Phts Riley-Smith Syndrome Bzs Ruvalcaba-Myhre-Smith Syndrome Multiple Hamartoma Syndrome Rmss Brrs Dysplastic Gangliocytoma Of The Cerebellum CWS1 Cs Cd Mham Pten Hamartoma Tumor Syndrome With Granular Cell Tumor Macrocephaly Multiple Lipomas And Hemangiomata Bannayan-Ruvalcaba-Riley Syndrome Myhre-Riley-Smith Syndrome LDD Cerebelloparenchymal Disorder Vi Hamartoma Syndrome, Multiple Bbrs Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata Macrocephaly, Multiple Lipomas, And Hemangiomata Macrocephaly Pseudopapilledema And Multiple Hemangiomas Ruvalcaba -Myhre-Smith Syndrome Ruvalcaba-Myhre Syndrome Cowden Disease Macrocephaly Pseudopapilledema And Multiple Hemangiomata Cerebellar Granule Cell Hypertrophy And Megalencephaly Cpd6 Pten Hamartoma Tumor Syndromes Cowden Syndrome, Type 1
Breast Ductal Carcinoma	Ductal Breast Carcinoma Duct Carcinoma Carcinoma, Ductal Mammary Ductal Carcinoma Ductal Carcinoma
Dysplastic Nevus Syndrome	Familial Atypical Multiple Mole-Melanoma Familial Atypical Multiple Mole Melanoma Syndrome Melanoma-Pancreatic Cancer Syndrome Famm Syndrome B-K Mole Syndrome Famm-Pc Syndrome Fammm Syndrome Familial Atypical Mole Syndrome Familial Atypical Multiple Mole Melanoma-Pancreatic Carcinoma Syndrome Familial Dysplastic Nevus Syndrome Familial Atypical Multiple Mole Melanoma Dysplastic Nevus Familial Atypical Mole Melanoma Syndrome
Diffuse Gastric And Lobular Breast Cancer Syndrome	Hereditary Diffuse Gastric Cancer HDGC LBC Familial Diffuse Gastric Cancer Fdgc Hereditary Diffuse Gastric Adenocarcinoma Breast Cancer, Lobular Gastric Cancer, Familial Diffuse, And Cleft Lip With Or Without Cleft Palate DGLBC Gastric Cancer, Hereditary Diffuse Gastric Cancer, Familial Diffuse Breast Cancer, Lobular Diffuse Gastric And Lobular Breast Cancer Syndrome With Or Without Cleft Lip And/Or Palate E-Cadherin-Associated Hereditary Gastric Cancer Familial Diffuse Cancer Of Stomach Hereditary Diffuse Cancer Of Stomach Gastric Cancer Familial Diffuse Gastric Cancer Familial Diffuse And Cleft Lip With Or Without Cleft Palate Cancer, Gastric, Hereditary Diffuse
Peritoneum Cancer	Peritoneal Neoplasm Cancer Of Peritoneum Malignant Tumor Of Peritoneum Peritoneal Neoplasms
Cancerophobia	Cancer Phobia Fear Of Getting Cancer
Lobular Neoplasia	Lobular Carcinoma In Situ Lobular Carcinoma In Situ Of Breast Lobular Intraepithelial Neoplasia Non-Infiltrating Lobular Carcinoma Noninfiltrating Lobular Carcinoma Unspecified Site Noninfiltrating Lobular Carcinoma Of Breast Lobular Carcinoma In Situ Unspecified Site
In Situ Carcinoma	Carcinoma In Situ
Nosophobia
Pre-Malignant Neoplasm
Breast Disease	Breast Diseases
Ovarian Carcinosarcoma	Ovarian Malignant Mixed Mullerian Tumor Mmmt Of The Ovary Malignant Mixed Mullerian Tumor Of The Ovary Ovarian Malignant Mixed Epithelial Mesenchymal Tumor Ovarian Malignant Mesodermal Mixed Tumor Ovarian Mmmt Malignant Mixed Müllerian Tumor Of The Ovary Ovarian Malignant Mixed Müllerian Tumor Carcinosarcoma Of Ovary
Synchronous Bilateral Breast Carcinoma
Carcinosarcoma	Mixed Tumor, Mullerian Malignant Mixed Mesodermal Tumor Malignant Mixed Mullerian Tumor Mmmt Mixed Tumor, Mesodermal Mesodermal Mixed Tumor Mixed Mesodermal Tumor Mullerian Mixed Tumor Mixed Mullerian Tumor Malignant Mixed Müllerian Tumor Mixed Müllerian Tumor Mixed Tumor Mullerian Mixed Tumor, Not Otherwise Specified
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Breast Lobular Carcinoma	Cancer, Breast, Lobular Lobular Breast Carcinoma
Diffuse Gastric Cancer	Hereditary Diffuse Gastric Adenocarcinoma Hereditary Diffuse Gastric Cancer Signet Cell Adenocarcinoma Signet Ring Cell Carcinoma Signet Ring Cell Gastric Carcinoma Signet Ring Gastric Carcinoma Fdgc Familial Diffuse Cancer Of Stomach Familial Diffuse Gastric Cancer Gastric Cancer, Familial Diffuse Gastric Cancer, Hereditary Diffuse Hdgc Hereditary Diffuse Cancer Of Stomach Diffuse Gastric Cancer Syndrome Cancer, Gastric, Diffuse Carcinoma, Signet Ring Cell Gastric Signet Ring Carcinoma
Choroid Plexus Cancer	Choroid Plexus Carcinoma Choroid Plexus Neoplasms Choroid Plexus Neoplasm Tumor Of Choroid Plexus Tumor Of The Choroid Plexus Choroid Plexus Tumor Choroid Plexus Tumors Anaplastic Choroid Plexus Papilloma Choroid Plexus Papilloma Nos Papilloma Of Choroid Plexus Plexus Choroideus Papilloma Choroid Plexus Papilloma In Fourth Ventricle Plexus Choroideus Papilloma In Fourth Ventricle
Serous Cystadenocarcinoma	Serous Adenocarcinoma Cystadenocarcinoma, Serous Serous Carcinoma Cystadenocarcinoma Serous
Ductal Carcinoma In Situ	Noninfiltrating Intraductal Carcinoma
Ovarian Disease	Ovarian Dysfunction Ovarian Diseases Ovarian Disorders Disorder Of Endocrine Ovary
Papillary Serous Adenocarcinoma	Micropapillary Serous Carcinoma Serous Surface Papillary Carcinoma Papillary Serous Carcinoma Papillary Serous Cystadenocarcinoma
Tay-Sachs Disease	Hexosaminidase A Deficiency TSD Hexa Deficiency Gm2 Gangliosidosis, Type 1 Hexosaminidase Alpha-Subunit Deficiency Gm2-Gangliosidosis, Several Forms Gm2-Gangliosidosis, B, B1, Ab Variant B Variant Gm2 Gangliosidosis Sphingolipidosis, Tay-Sachs Gm2-Gangliosidosis, Type I B Variant Gm2-Gangliosidosis Hex A Pseudodeficiency Hexa Disorders Beta-Hexosaminidase A Deficiency Gm2 Gangliosidosis, Type I Gangliosidosis Gm2 , Type 1 Gm2 Gangliosidosis, B, B1 Variant Gm2-Gangliosidosis 1 GM2G1 Gm2-Gangliosidosis B Variant Tay-Sachs Disease Pseudo-Ab Variant Tay-Sachs Disease Variant B1 Gangliosidoses, Gm2
Fanconi Anemia, Complementation Group N	Fanconi Anemia Complementation Group N FANCN
Hypertrophy Of Breast	Breasts Enlarged Large Breast Hypertrophy Of Breast Nos Hypertrophy Of Male Breast Hypertrophic Breast Excessive Development Of Breast Macromastia Mastoplastia
Ovary Transitional Cell Carcinoma	Malignant Ovarian Transitional Cell Neoplasm Ovarian Transitional Cell Cancer Ovarian Transitional Cell Neoplasm Transitional Cell Carcinoma Of Ovary Ovarian Transitional Cell Carcinoma Malignant Ovarian Transitional Cell Tumor Ovarian Transitional Cell Tumor
Endosalpingiosis
Lynch Syndrome I	Lynch Syndrome 1 Colorectal Cancer, Hereditary Nonpolyposis, Type 1 HNPCC1 Fcc1 Lynch Syndrome Ii Colon Cancer, Familial Nonpolyposis, Type 1 Coca1 Familial Nonpolyposis Colon Cancer Type 1 Hereditary Nonpolyposis Colorectal Cancer Type 1 Hereditary Non-Polyposis Colorectal Cancer 1 Hereditary Non-Polyposis Colorectal Cancer 3 Hnpcc3 Lynch Cancer Family Syndrome Lynch Syndrome Lynch Syndrome Type I Lynch Syndrome Type Ii Cancer, Colorectal, Nonpolyposis, Hereditary, Type 1 Hereditary Nonpolyposis Colorectal Cancer Colorectal Cancer, Hereditary Nonpolyposis, Type 3 Hereditary Non-Polyposis Colon Cancer Type 2
Combined Oxidative Phosphorylation Deficiency 17	COXPD17 Combined Oxidative Phosphorylation Defect Type 17 Combined Oxidative Phosphorylation Deficiency, Type 17
Pancreatic Acinar Cell Adenocarcinoma	Pancreatic Acinar Cell Carcinoma Acinar Cell Adenocarcinoma Of The Pancreas
Breast Benign Neoplasm	Benign Tumour Of Breast Benign Neoplasm Of Female Breast
Thoracic Benign Neoplasm	Benign Neoplasm Of Thorax
Estrogen-Receptor Negative Breast Cancer
Basaloid Lung Carcinoma	Basaloid Lung Cancer
Malignant Ovarian Surface Epithelial-Stromal Neoplasm	Malignant Ovarian Surface Epithelial-Stromal Tumor
Mismatch Repair Cancer Syndrome	Turcot Syndrome Brain Tumor-Polyposis Syndrome 1 Btp1 Syndrome Btps1 Childhood Cancer Syndrome Cmmr-D Syndrome Cmmrds Constitutional Mismatch Repair Deficiency Syndrome Mmr Deficiency Cancer Syndrome, Mismatch Repair Malignant Childhood Neoplasm
Ovarian Cystadenocarcinoma	Cystadenocarcinoma Of Ovary Cystadenocarcinoma Of The Ovary
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Ovary Adenocarcinoma	Ovarian Adenocarcinoma Adenocarcinoma Of The Ovary Ovarian Adenoacanthoma Adenocarcinoma Of Ovary
Comedo Carcinoma	Comedocarcinoma High Grade Ductal Breast Carcinoma In Situ
Cystadenocarcinoma
Physical Disorder	Physical Illness
Female Reproductive Endometrioid Cancer	Endometrioid Tumor Endometrioid Neoplasm Female Reproductive Endometrioid Neoplasm
Autosomal Recessive Cerebellar Ataxia	Arca
Muir-Torre Syndrome	MRTES Keratoacanthoma Muir-Torré Syndrome Cutaneous Sebaceous Neoplasms And Keratoacanthomas, Multiple, With Gastrointestinal And Other Carcinomas Cutaneous Sebaceous Neoplasms And Keratoacanthomas Multiple With Gastrointestinal And Other Carcinomas Multiple Keratoacanthoma, Muir-Torre Type Mts Torre-Muir Syndrome
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Ovary Epithelial Cancer	Ovarian Surface Epithelial-Stromal Tumor Epithelial Tumor Of Ovary
Breast Fibroadenoma	Fibroadenoma Fibroadenoma Of Breast Juvenile Fibroadenoma Of Breast Cellular Fibroadenoma Complex Fibroadenoma Of Breast Juvenile Fibroadenoma Fibroadenoma Nos Fibroadenoma Unspecified Site
Familial Adenomatous Polyposis 2	Mutyh-Related Attenuated Familial Adenomatous Polyposis FAP2 Colorectal Adenomatous Polyposis, Autosomal Recessive Adenomas, Multiple Colorectal Mutyh-Associated Polyposis Mutyh-Related Attenuated Familial Polyposis Coli Mutyh-Related Attenuated Fap Adenomas, Multiple Colorectal, Autosomal Recessive Mutyh-Related Afap Adenomas Multiple Colorectal Autosomal Recessive Colorectal Adenomatous Polyposis Autosomal Recessive Adenomatous Polyposis, Familial, Type 2
Ovarian Serous Carcinoma	Ovarian Serous Adenocarcinoma
X-Linked Intellectual Disability-Cardiomegaly-Congestive Heart Failure Syndrome	Mental Retardation, X-Linked, Syndromic 32 Mrxs32
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Neurofibromatosis, Type I	Von Recklinghausen Disease Neurofibromatosis 1 Neurofibromatosis, Type 1 NF1 Neurofibromatosis, Peripheral Type Neurofibromatosis Type I Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion Familial Spinal Neurofibromatosis Fsnf Peripheral Neurofibromatosis Von Recklinghausen'S Neurofibromatosis Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion Neurofibromatosis Peripheral Type Von Recklinghausen Syndrome Neurofibromatosis Type 1 Von Recklinghausen Neuropathy Nf1 - [Neurofibromatosis Type 1] Recklinghausen Disease
Ovarian Serous Cystadenocarcinoma	Serous Cystadenoma Cystadenoma Serous Cystadenoma, Serous
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Ciliary Dyskinesia, Primary, 5	Primary Ciliary Dyskinesia 5 CILD5 Ciliary Dyskinesia, Primary, 5, Without Situs Inversus Primary Ciliary Dyskinesia 5 Without Situs Inversus Ics5 Immotile Cilia Syndrome 5 Primary Ciliary Dyskinesia 5 With Or Without Situs Inversus Dyskinesia, Ciliary, Primary, Type 5
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Nijmegen Breakage Syndrome	Berlin Breakage Syndrome NBS Microcephaly, Normal Intelligence And Immunodeficiency Ataxia-Telangiectasia Variant Ataxia-Telangiectasia Variant V1 Seemanova Syndrome Ii Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome Seemanova Syndrome Type 2 At-V1 Microcephaly With Normal Intelligence, Immunodeficiency, And Lymphoreticular Malignancies Nonsyndromal Microcephaly, Autosomal Recessive, With Normal Intelligence Immunodeficiency, Microcephaly, And Chromosomal Instability Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome Microcephaly Immunodeficiency Lymphoreticuloma Microcephaly With Normal Intelligence Immunodeficiency And Lymphoreticular Malignancies Nonsyndromal Microcephaly Autosomal Recessive With Normal Intelligence Seemanova Syndrome 2 Ataxia-Telangiectasia Variant 1 Seemanova Syndrome At V1 Ataxia-Telangiectasia, Variant 1 Microcephaly-Immunodeficiency-Lymphoid Malignancy Syndrome V-At Ataxia Telangiectasia Variant V1
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 Melanoma, Malignant CMM1 Melanoma, Cutaneous Malignant Cmm Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma
Estrogen-Receptor Positive Breast Cancer
Uterine Corpus Cancer	Corpus Uteri Cancer Malignant Uterine Corpus Neoplasm
Testicular Disease	Testicular Dysfunction Testicular Diseases Disorder Of Testis Testis Disorder Testicular Disorders
Basal Cell Nevus Syndrome	Nevoid Basal Cell Carcinoma Syndrome Gorlin Syndrome Nbccs BCNS Gorlin-Goltz Syndrome Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies Cerebral Gigantism Jaw Cysts Cramer Niederdellmann Syndrome Gorlin Syndrome Or Gorlin-Goltz Syndrome Naevoid Basal Cell Carcinoma Syndrome
Cerebellar Disease	Cerebellar Diseases Cerebellar Dysfunction Cerebellar Abnormality Cerebellar Disorders
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Adrenal Cortical Carcinoma	Adrenocortical Carcinoma Adrenal Cortex Carcinoma Carcinoma Of The Adrenal Cortex Acc Adrenocortical Cancer Carcinoma Adrenocortical
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10617A	Rucaparib	Inhibitor	99.96%	Yes
HY-10617	Rucaparib phosphate	Inhibitor	99.76%	Yes
HY-102003	Rucaparib monocamsylate	Inhibitor	99.91%	Yes
HY-102003A	Rucaparib camsylate	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-115552	Simmiparib	Inhibitor	99.01%	Phase 1

Pre-clinical Phase

Bioactive Molecules (35)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124691	D-I03	Inhibitor	99.70%	Unkown
HY-151462	RP-6685	Inhibitor	99.96%	Unkown
HY-150147	CAM833		99.83%	Unkown
HY-170844	MU147	Inhibitor	99.35%	Unkown
HY-122639	ZINC05007751		99.33%	Unkown
HY-162706	BSJ-5-63	Degrader	99.97%	Unkown
HY-148183	Homologous recombination-IN-1	Inhibitor	98.65%	Unkown
HY-40041	(R)-1-Boc-3-methyl-piperazine		99.86%	Unkown
HY-161431	RTx-152		99.71%	Unkown
HY-168993	BRCA2-IN-2	Inhibitor	97.30%	Unkown
HY-177512	MSC778	Inhibitor	/	Unkown
HY-170845	MU1409	Inhibitor	98.52%	Unkown
HY-135782A	iso-ADP ribose TEA		99.97%	Unkown
HY-181557	SY-589		98.50%	Unkown
HY-135782	iso-ADP ribose		/	Unkown
HY-153338	C791-0064		99.15%	Unkown
HY-158346	RP-2119	Inhibitor	99.94%	Unkown
HY-RS01594	BRCA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-179219S	RTx-303	Inhibitor	/	Unkown
HY-10617AS1	Rucaparib-d3	Inhibitor	/	Unkown
HY-122583	D-G23	Inhibitor	/	Unkown
HY-132885	PARP/EZH2-IN-1	Inhibitor	/	Unkown
HY-150958	RAD51-IN-8		/	Unkown
HY-155766	PARP1-IN-14		/	Unkown
HY-163816	Antiproliferative agent-53-d3	Inhibitor	/	Unkown
HY-168094	PARP1-IN-30	Inhibitor	/	Unkown
HY-173151	BRCA2-IN-1	Inhibitor	/	Unkown
HY-173345	BRCA2-RAD51-IN-2	Inhibitor	/	Unkown
HY-179413	Polθ-IN-9	Inhibitor	/	Unkown
HY-182322	POLQ-IN-1	Inhibitor	/	Unkown
HY-P10516	BRC4 peptide		/	Unkown
HY-162104	BRCA2-RAD51-IN-1	Inhibitor	/	Unkown
HY-181561	BRCA2-RAD51-IN-3	Inhibitor	/	Unkown
HY-RS16825	Brca2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23267	Brca2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	BRCA2	VGNC	VGNC:60166
Macaca mulatta	BRCA2	VGNC	VGNC:70279
Rattus norvegicus	BRCA2	RGD	RGD:2219
Mus musculus	BRCA2	MGD	MGI:109337
Bos taurus	BRCA2	VGNC	VGNC:26554
Canis familiaris	BRCA2	VGNC	VGNC:38517
Others	BRCA2	NCBI