PARP1-IN-14
PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor, with an IC50 of 0.6 ± 0.1 nM. PARP1-IN-14 exhibits antiproliferative effect against both MDA-MB-436 (BRCA1−/−) and Capan-1 (BRCA2−/−) cells with IC50 values below 0.3 nM.
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- No. CAS: 2098639-70-2
- Fòrmula: C28H24FN7O3
- Peso molecular:525.53
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Actividad biológica
Descripciòn
IC50 & Target
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PARP1 0.6 ± 0.1 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CAPAN-1 | IC50 |
<0.3 nM
Compound: 19k
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Antiproliferative activity against human CAPAN-1 BRCA2-/- cells assessed as inhibition of cell growth incubated for 7 days by CCK-8 assay
Antiproliferative activity against human CAPAN-1 BRCA2-/- cells assessed as inhibition of cell growth incubated for 7 days by CCK-8 assay
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[PMID: 37567056] |
| MDA-MB-436 | IC50 |
<0.3 nM
Compound: 19k
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Antiproliferative activity against human MDA-MB-436 BRCA1-/- cells assessed as inhibition of cell growth incubated for 7 days by CCK-8 assay
Antiproliferative activity against human MDA-MB-436 BRCA1-/- cells assessed as inhibition of cell growth incubated for 7 days by CCK-8 assay
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[PMID: 37567056] |
In Vitro
PARP1-IN-14 (compound 19k) significantly inhibited proliferation of resistant Capan-1 cells (IC50s < 0.3 nM)[1].
PARP1-IN-14 (0-1 μM, 24 h) induces DNA damage in parental Capan-1 (BRCA2−/−) and resistant Capan-1 cells[1].
PARP1-IN-14 (0-1 μM, 0-48 h) induces cell cycle arrest and apoptosis in parental and resistant cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2098639-70-2
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Peso molecular 525.53
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Fòrmula C28H24FN7O3
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SMILES
O=C1NN=C(CC2=CC=C(F)C(C(N3CC4=NN=C(C5=NC(OC)=CC=C5)N4C(C)C3)=O)=C2)C6=C1C=CC=C6
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PARP1-IN-14 Related Classifications
HY-155766 Related Classifications
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