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製品番号: HY-162104

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BRCA2-RAD51-IN-1

BRCA2-RAD51-IN-1 (Compound 46) is a BRCA2-RAD51 inhibitor with an EC₅₀ value of 28 μM. BRCA2-RAD51-IN-1 has antitumor activity.

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CAS 番号: 2830213-53-9
分子式: C₁₃H₇BrF₃N₃O
分子量:358.11

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

BRCA2-RAD51-IN-1 構造式

CAS 番号: 2830213-53-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

BRCA2-RAD51-IN-1 (Compound 46) is a BRCA2-RAD51 inhibitor with an EC₅₀ value of 28 μM. BRCA2-RAD51-IN-1 has antitumor activity^[1].

IC₅₀ & Target

EC50: 28 μM (BRCA2-RAD51) ^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
ASPC1	IC₅₀	2.66 μM Compound: 46	Antiproliferative activity against human ASPC1 cells assessed as inhibition of cell growth incubated for 6 days by prestoblue reagent based assay Antiproliferative activity against human ASPC1 cells assessed as inhibition of cell growth incubated for 6 days by prestoblue reagent based assay	[PMID: 38194775]
BXPC-3	IC₅₀	1.8 μM Compound: 46	Antiproliferative activity against human BXPC-3 cells assessed as inhibition of cell growth incubated for 6 days by prestoblue reagent based assay Antiproliferative activity against human BXPC-3 cells assessed as inhibition of cell growth incubated for 6 days by prestoblue reagent based assay	[PMID: 38194775]
BXPC-3	IC₅₀	7.83 μM Compound: 46	Inhibition of homologous recombination in human BXPC-3 cells incubated for 5 hrs by real-time PCR analysis Inhibition of homologous recombination in human BXPC-3 cells incubated for 5 hrs by real-time PCR analysis	[PMID: 38194775]
HPAC	IC₅₀	2.27 μM Compound: 46	Antiproliferative activity against human HPAC cells assessed as inhibition of cell growth incubated for 6 days by prestoblue reagent based assay Antiproliferative activity against human HPAC cells assessed as inhibition of cell growth incubated for 6 days by prestoblue reagent based assay	[PMID: 38194775]

化学情報

CAS 番号 2830213-53-9
分子量 358.11
分子式 C₁₃H₇BrF₃N₃O
SMILES

BrC1=CC=CC(C(NC2=CC(C(F)(F)F)=NN23)=CC3=O)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Myers SH, et al. An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer. Eur J Med Chem. 2023 Dec 31;265:116114. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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