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Cat. No.: HY-162104

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BRCA2-RAD51-IN-1

BRCA2-RAD51-IN-1 (Compound 46) is a BRCA2-RAD51 inhibitor with an EC₅₀ value of 28 μM. BRCA2-RAD51-IN-1 has antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 2830213-53-9
Formula: C₁₃H₇BrF₃N₃O
Molecular Weight:358.11

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

BRCA2-RAD51-IN-1 Chemical Structure

CAS No.: 2830213-53-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

BRCA2-RAD51-IN-1 (Compound 46) is a BRCA2-RAD51 inhibitor with an EC₅₀ value of 28 μM. BRCA2-RAD51-IN-1 has antitumor activity^[1].

IC₅₀ & Target

EC50: 28 μM (BRCA2-RAD51) ^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
ASPC1	IC₅₀	2.66 μM Compound: 46	Antiproliferative activity against human ASPC1 cells assessed as inhibition of cell growth incubated for 6 days by prestoblue reagent based assay Antiproliferative activity against human ASPC1 cells assessed as inhibition of cell growth incubated for 6 days by prestoblue reagent based assay	[PMID: 38194775]
BXPC-3	IC₅₀	1.8 μM Compound: 46	Antiproliferative activity against human BXPC-3 cells assessed as inhibition of cell growth incubated for 6 days by prestoblue reagent based assay Antiproliferative activity against human BXPC-3 cells assessed as inhibition of cell growth incubated for 6 days by prestoblue reagent based assay	[PMID: 38194775]
BXPC-3	IC₅₀	7.83 μM Compound: 46	Inhibition of homologous recombination in human BXPC-3 cells incubated for 5 hrs by real-time PCR analysis Inhibition of homologous recombination in human BXPC-3 cells incubated for 5 hrs by real-time PCR analysis	[PMID: 38194775]
HPAC	IC₅₀	2.27 μM Compound: 46	Antiproliferative activity against human HPAC cells assessed as inhibition of cell growth incubated for 6 days by prestoblue reagent based assay Antiproliferative activity against human HPAC cells assessed as inhibition of cell growth incubated for 6 days by prestoblue reagent based assay	[PMID: 38194775]

Chemical Information

CAS No. 2830213-53-9
Molecular Weight 358.11
Formula C₁₃H₇BrF₃N₃O
SMILES

BrC1=CC=CC(C(NC2=CC(C(F)(F)F)=NN23)=CC3=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Myers SH, et al. An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer. Eur J Med Chem. 2023 Dec 31;265:116114. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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