Antiproliferative agent-53-d3
Antiproliferative agent-53-d3 (Compound C1) is an inhibitor for theta-mediated end joining (TMEJ) in HEK293 cell with an IC50 of 0.14 µM. Antiproliferative agent-53-d3 is the inhibitor for CYP2C19 and CYP2C9 with IC50 of 0.77 and 3.1 µM. Antiproliferative agent-53-d3 inhibits the proliferation of DNA repair-compromised cells, with IC50 of 8.1 µM for BRCA2-/- DLD-1. Antiproliferative agent-53-d3 exhibits good pharmacokinetic characteristics in CD-1 mice.
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- CAS No.: 2923508-77-2
- Formula: C20H14D3ClF4N4O2
- Molecular Weight:459.84
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CYP2C19 0.77 μM (IC50) |
CYP2C9 3.1 μM (IC50) |
CYP3A4 14.6 μM (IC50) |
CYP2D6 17.3 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| DLD-1 | IC50 |
8.1 μM
Compound: C1
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Antiproliferative activity against BRCA2 deficient human DLD-1 cells assessed as inhibition of cell growth incubated for 7 days by Cell-titer glo luminescence assay
Antiproliferative activity against BRCA2 deficient human DLD-1 cells assessed as inhibition of cell growth incubated for 7 days by Cell-titer glo luminescence assay
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[PMID: 38493730] |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2923508-77-2
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Molecular Weight 459.84
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Formula C20H14D3ClF4N4O2
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SMILES
[2H]C([2H])([2H])N(C1=CC(Cl)=C(C=C1)F)C([C@H]2N(C3=C(C(C(F)(F)F)=CC(C)=N3)C#N)C[C@H]2CO)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antiproliferative agent-53-d3 Related Classifications
HY-163816 Related Classifications
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