Homologous recombination-IN-1
Based on 1 Customer Validation
Homologous recombination-IN-1 is a novel RAD51-BRCA2 protein-protein interaction inhibitor (EC50=19 μM). Homologous recombination-IN-1 can interfere with homologous recombination.
For research use only. We do not sell to patients.
- Purity: 98.65%
- CAS No.: 391889-85-3
- Formula: C28H24ClN3O3
- Molecular Weight:485.96
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Homologous recombination-IN-1 (10-40 μM; 5 h) reduces cell homologous recombination in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BxPC3 cells
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Concentration:10-40 μM
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Incubation Time:5 hours
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Result:Led to homologous recombination inhibition with an EC50 value of 18.4 μM.
Chemical Information
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CAS No. 391889-85-3
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Appearance Solid
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Molecular Weight 485.96
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Formula C28H24ClN3O3
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Color Light yellow to yellow
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SMILES
O=C1NC2=C(C(C3=CC=CC=C3)=C1C4=NN(C(C4)C5=CC=C(C=C5)OC)C(CC)=O)C=C(Cl)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (102.89 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0578 mL | 10.2889 mL | 20.5778 mL | 51.4446 mL |
| 5 mM | 0.4116 mL | 2.0578 mL | 4.1156 mL | 10.2889 mL | |
| 10 mM | 0.2058 mL | 1.0289 mL | 2.0578 mL | 5.1445 mL | |
| 15 mM | 0.1372 mL | 0.6859 mL | 1.3719 mL | 3.4296 mL | |
| 20 mM | 0.1029 mL | 0.5144 mL | 1.0289 mL | 2.5722 mL | |
| 25 mM | 0.0823 mL | 0.4116 mL | 0.8231 mL | 2.0578 mL | |
| 30 mM | 0.0686 mL | 0.3430 mL | 0.6859 mL | 1.7148 mL | |
| 40 mM | 0.0514 mL | 0.2572 mL | 0.5144 mL | 1.2861 mL | |
| 50 mM | 0.0412 mL | 0.2058 mL | 0.4116 mL | 1.0289 mL | |
| 60 mM | 0.0343 mL | 0.1715 mL | 0.3430 mL | 0.8574 mL | |
| 80 mM | 0.0257 mL | 0.1286 mL | 0.2572 mL | 0.6431 mL | |
| 100 mM | 0.0206 mL | 0.1029 mL | 0.2058 mL | 0.5144 mL |
Homologous recombination-IN-1 Related Classifications
HY-148183 Related Classifications
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