1. Cell Cycle/DNA Damage
  2. RAD51
  3. Homologous recombination-IN-1

Homologous recombination-IN-1 is a novel RAD51-BRCA2 protein-protein interaction inhibitor (EC50=19 μM). Homologous recombination-IN-1 can interfere with homologous recombination.

For research use only. We do not sell to patients.

Homologous recombination-IN-1 Chemical Structure

Homologous recombination-IN-1 Chemical Structure

CAS No. : 391889-85-3

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 225 In-stock
Solution
10 mM * 1 mL in DMSO USD 225 In-stock
Solid
5 mg USD 210 In-stock
10 mg USD 370 In-stock
25 mg USD 840 In-stock
50 mg USD 1450 In-stock
100 mg USD 2300 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Homologous recombination-IN-1 is a novel RAD51-BRCA2 protein-protein interaction inhibitor (EC50=19 μM). Homologous recombination-IN-1 can interfere with homologous recombination[1].

In Vitro

Homologous recombination-IN-1 (10-40 μM; 5 h) reduces cell homologous recombination in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: BxPC3 cells
Concentration: 10-40 μM
Incubation Time: 5 hours
Result: Led to homologous recombination inhibition with an EC50 value of 18.4 μM.
Molecular Weight

485.96

Formula

C28H24ClN3O3

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1NC2=C(C(C3=CC=CC=C3)=C1C4=NN(C(C4)C5=CC=C(C=C5)OC)C(CC)=O)C=C(Cl)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (102.89 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0578 mL 10.2889 mL 20.5778 mL
5 mM 0.4116 mL 2.0578 mL 4.1156 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0578 mL 10.2889 mL 20.5778 mL 51.4446 mL
5 mM 0.4116 mL 2.0578 mL 4.1156 mL 10.2889 mL
10 mM 0.2058 mL 1.0289 mL 2.0578 mL 5.1445 mL
15 mM 0.1372 mL 0.6859 mL 1.3719 mL 3.4296 mL
20 mM 0.1029 mL 0.5144 mL 1.0289 mL 2.5722 mL
25 mM 0.0823 mL 0.4116 mL 0.8231 mL 2.0578 mL
30 mM 0.0686 mL 0.3430 mL 0.6859 mL 1.7148 mL
40 mM 0.0514 mL 0.2572 mL 0.5144 mL 1.2861 mL
50 mM 0.0412 mL 0.2058 mL 0.4116 mL 1.0289 mL
60 mM 0.0343 mL 0.1715 mL 0.3430 mL 0.8574 mL
80 mM 0.0257 mL 0.1286 mL 0.2572 mL 0.6431 mL
100 mM 0.0206 mL 0.1029 mL 0.2058 mL 0.5144 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Homologous recombination-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Homologous recombination-IN-1
Cat. No.:
HY-148183
Quantity:
MCE Japan Authorized Agent: