Homologous recombination-IN-1

Name: Homologous recombination-IN-1
Brand: MedChemExpress
SKU: HY-148183
Rating: 4.5 (1 reviews)

Cat. No.: HY-148183 Pureza: 98.65%: Ficha de datos
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Homologous recombination-IN-1 is a novel RAD51-BRCA2 protein-protein interaction inhibitor (EC₅₀=19 μM). Homologous recombination-IN-1 can interfere with homologous recombination.

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Homologous recombination-IN-1 Estructura química

No. CAS : 391889-85-3

Tamaño	Stock	Cantidad

Muestra gratis (0.1 - 0.2 mg)	Solicite ahora
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

Other Forms of Homologous recombination-IN-1:

BRCA2-RAD51-IN-2 Obtener un presupuesto

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Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

Homologous recombination-IN-1 is a novel RAD51-BRCA2 protein-protein interaction inhibitor (EC₅₀=19 μM). Homologous recombination-IN-1 can interfere with homologous recombination^[1].

In Vitro

Homologous recombination-IN-1 (10-40 μM; 5 h) reduces cell homologous recombination in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	BxPC3 cells
Concentration:	10-40 μM
Incubation Time:	5 hours
Result:	Led to homologous recombination inhibition with an EC₅₀ value of 18.4 μM.

Peso molecular

485.96

Fòrmula

C₂₈H₂₄ClN₃O₃

No. CAS

391889-85-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1NC2=C(C(C3=CC=CC=C3)=C1C4=NN(C(C4)C5=CC=C(C=C5)OC)C(CC)=O)C=C(Cl)C=C2

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 50 mg/mL (102.89 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0578 mL	10.2889 mL	20.5778 mL
5 mM	0.4116 mL	2.0578 mL	4.1156 mL
10 mM	0.2058 mL	1.0289 mL	2.0578 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 98.65%

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Ficha de datos (274 KB) SDS (251 KB)

COA (251 KB) HNMR (123 KB) LCMS (106 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Bagnolini G, et al. Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib. J Med Chem. 2020 Mar 12;63(5):2588-2619. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0578 mL	10.2889 mL	20.5778 mL	51.4446 mL
	5 mM	0.4116 mL	2.0578 mL	4.1156 mL	10.2889 mL
	10 mM	0.2058 mL	1.0289 mL	2.0578 mL	5.1445 mL
	15 mM	0.1372 mL	0.6859 mL	1.3719 mL	3.4296 mL
	20 mM	0.1029 mL	0.5144 mL	1.0289 mL	2.5722 mL
	25 mM	0.0823 mL	0.4116 mL	0.8231 mL	2.0578 mL
	30 mM	0.0686 mL	0.3430 mL	0.6859 mL	1.7148 mL
	40 mM	0.0514 mL	0.2572 mL	0.5144 mL	1.2861 mL
	50 mM	0.0412 mL	0.2058 mL	0.4116 mL	1.0289 mL
	60 mM	0.0343 mL	0.1715 mL	0.3430 mL	0.8574 mL
	80 mM	0.0257 mL	0.1286 mL	0.2572 mL	0.6431 mL
	100 mM	0.0206 mL	0.1029 mL	0.2058 mL	0.5144 mL