DMC1 - DNA meiotic recombinase 1 Gene

Also Known as DMC1H; LIM15; dJ199H16.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11144

About DMC1

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,509,147-38,570,183 (from NCBI)

This gene has 6 transcripts (splice variants), 188 orthologues, 6 paralogues and is associated with 1 phenotype. Biased expression in testis (RPKM 4.8), lymph node (RPKM 0.7) and 8 other tissues.

Summary

This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during Mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

DMC1 Products (3)

mRNA Protein Name
NM_001278208.2 NP_001265137.1 meiotic recombination protein DMC1/LIM15 homolog isoform 2
NM_001363017.2 NP_001349946.1 meiotic recombination protein DMC1/LIM15 homolog isoform 2
NM_007068.4 NP_008999.2 meiotic recombination protein DMC1/LIM15 homolog isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP-dependent activity, acting on DNA IDA
IDA: Inferred from direct assay
15899844 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17541404 GOA
Biological Process GO Annotation Evidence References Source
involved in reciprocal meiotic recombination IDA
IDA: Inferred from direct assay
21307306 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
22899867 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DMC1 Protein Structure

Rad51

Rad51: Rad51 (84 - 339)

  • 0
  • 100
  • 200
  • 300
  • 340 a.a.
Protein Preferred Names Protein Names

meiotic recombination protein DMC1/LIM15 homolog

  • DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination

DMC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DMC1 Q14565 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
DMC1 Q14565 UBE2I Homo sapiens Q7KZS0
Validated Y2H
32296183
Intra
DMC1 Q14565 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
DMC1 Q14565 PSMA3 Homo sapiens P25788
Y2H Array
25416956
Intra
DMC1 Q14565 PSMA3 Homo sapiens P25788
Y2H Bait-Prey Pool
25910212
Intra
DMC1 Q14565 PSMA3 Homo sapiens P25788
Validated Y2H
25910212
Intra
DMC1 Q14565 PSMA3 Homo sapiens P25788
Y2H Array
25910212
Intra
DMC1 Q14565 PIAS2 Homo sapiens O75928-2
Y2H Array
32296183
Intra
DMC1 Q14565 PIAS2 Homo sapiens O75928-2
Y2H Prey Pooling
32296183
Intra
DMC1 Q14565 SDCBP Homo sapiens O00560
Y2H Bait-Prey Pool
25910212
Intra
DMC1 Q14565 SDCBP Homo sapiens O00560
Validated Y2H
25910212
Intra
DMC1 Q14565 SDCBP Homo sapiens O00560
Y2H Array
25910212
Intra
DMC1 Q14565 SDCBP Homo sapiens O00560
Y2H Array
25416956
Intra
DMC1 Q14565 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra
DMC1 Q14565 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
25416956
Intra
DMC1 Q14565 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
Intra
DMC1 Q14565 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
Intra
DMC1 Q14565 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
31515488
Intra
DMC1 Q14565 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
DMC1 Q14565 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
Intra
DMC1 Q14565 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
Intra
DMC1 Q14565 TRIM23 Homo sapiens P36406
Validated Y2H
25416956
Intra
DMC1 Q14565 NIF3L1 Homo sapiens Q9GZT8
Y2H Bait-Prey Pool
25910212
Intra
DMC1 Q14565 NIF3L1 Homo sapiens Q9GZT8
Y2H Array
32296183
Intra
DMC1 Q14565 NIF3L1 Homo sapiens Q9GZT8
Validated Y2H
25910212
Intra
DMC1 Q14565 NIF3L1 Homo sapiens Q9GZT8
Y2H Prey Pooling
25416956
Intra
DMC1 Q14565 NIF3L1 Homo sapiens Q9GZT8
Y2H Array
25910212
Intra
DMC1 Q14565 NIF3L1 Homo sapiens Q9GZT8
Validated Y2H
25416956
Intra
DMC1 Q14565 NIF3L1 Homo sapiens Q9GZT8
Y2H Prey Pooling
32296183
Intra
DMC1 Q14565 NIF3L1 Homo sapiens Q9GZT8
Validated Y2H
32296183
Intra
DMC1 Q14565 SDCBP2 Homo sapiens Q9H190
Y2H Prey Pooling
32296183
Intra
DMC1 Q14565 SDCBP2 Homo sapiens Q9H190
Validated Y2H
32296183
Intra
DMC1 Q14565 SDCBP2 Homo sapiens Q9H190
Y2H Array
32296183
Intra
DMC1 Q14565 KCTD17 Homo sapiens Q8N5Z5
Y2H Prey Pooling
25416956
Intra
DMC1 Q14565 KCTD17 Homo sapiens Q8N5Z5
Y2H Array
25416956
Intra
DMC1 Q14565 KCTD17 Homo sapiens Q8N5Z5
Validated Y2H
25416956
Intra
DMC1 Q14565 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
DMC1 Q14565 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
DMC1 Q14565 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
DMC1 Q14565 BRCA2 Homo sapiens P51587
Y2H
17541404
Intra
DMC1 Q14565 BRCA2 Homo sapiens P51587
Pull Down
17541404
Intra
DMC1 Q14565 BRCA2 Homo sapiens P51587
Competition Binding
17541404
Intra
DMC1 Q14565 BRCA2 Homo sapiens P51587
Peptide Array
17541404
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Infertility
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03822 DMC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06167 HID1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DMC1 VGNC VGNC:71931
Bos taurus DMC1 VGNC VGNC:28105
Canis familiaris DMC1 VGNC VGNC:39998
Mus musculus DMC1 MGD MGI:105393
Felis catus DMC1 VGNC VGNC:83867
Rattus norvegicus DMC1 RGD RGD:1307611
Others DMC1 NCBI