HDAC6-IN-63
HDAC6-IN-63 (Compound 7) is an orally active HDAC6 inhibitor with an IC50 of 145 nM. HDAC6-IN-63 inhibits the expression of Sp1 and RAD51, thereby inducing Caspase-dependent apoptosis. HDAC6-IN-63 has antitumor activity and sensitizes Etoposide (HY-13629) and Gemcitabine (HY-17026), promoting synergistic death of NSCLC cells through the inhibition of homologous recombination and non-homologous end joining (NHEJ) pathways involved in DNA DSB repair. HDAC6-IN-63 can be used for chemotherapy of cancers like NSCLC research.
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- 分子式: C25H23N3O3S
- 分子量:445.53
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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HDAC6 145 nM (IC50) |
Caspase-9 |
Caspase-3 |
Caspase-7 |
HDAC1 4106 nM (IC50) |
HDAC4 1738 nM (IC50) |
化学情報
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分子量 445.53
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分子式 C25H23N3O3S
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SMILES
O=C(N(C(C1=CC=CC=C12)=O)CCC3=CC=CC=C3)N2CC(C=C4)=CC=C4NC(CS)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
HDAC6-IN-63 関連分類
HY-178022 関連分類
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