HDAC6-IN-63
HDAC6-IN-63 (Compound 7) is an orally active HDAC6 inhibitor with an IC50 of 145 nM. HDAC6-IN-63 inhibits the expression of Sp1 and RAD51, thereby inducing Caspase-dependent apoptosis. HDAC6-IN-63 has antitumor activity and sensitizes Etoposide (HY-13629) and Gemcitabine (HY-17026), promoting synergistic death of NSCLC cells through the inhibition of homologous recombination and non-homologous end joining (NHEJ) pathways involved in DNA DSB repair. HDAC6-IN-63 can be used for chemotherapy of cancers like NSCLC research.
For research use only. We do not sell to patients.
- Formula: C25H23N3O3S
- Molecular Weight:445.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HDAC6 145 nM (IC50) |
Caspase-9 |
Caspase-3 |
Caspase-7 |
HDAC1 4106 nM (IC50) |
HDAC4 1738 nM (IC50) |
Chemical Information
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Molecular Weight 445.53
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Formula C25H23N3O3S
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SMILES
O=C(N(C(C1=CC=CC=C12)=O)CCC3=CC=CC=C3)N2CC(C=C4)=CC=C4NC(CS)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC6-IN-63 Related Classifications
HY-178022 Related Classifications
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