1. Dye Reagents

DIDS sodium salt (Synonyms: MDL101114ZA)

Cat. No.: HY-D0086 Purity: >98.0%
Handling Instructions

DIDS sodium salt is a dual ABCA1 and VDAC1 inhibitor.

For research use only. We do not sell to patients.

DIDS sodium salt Chemical Structure

DIDS sodium salt Chemical Structure

CAS No. : 67483-13-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
50 mg USD 80 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

DIDS sodium salt is a dual ABCA1 and VDAC1 inhibitor.

IC50 & Target

ABCA1[1], VDAC1[2].

In Vitro

Concentration less than 400 μM DIDS has no evident cytotoxic effect on cell viability Pre-treatment with DIDS at the concentration of 100 and 200 μM result in a prevented effect on ALA-SDT-induced cell death, while dose at 50 μM has no inhibition effect. At the concentration of 400 μM DIDS itself slightly decreases the cell viability, although there is no significant statistic difference as compared with the untreated control. Pre-treatment with DIDS (100 μM) clearly inhibit caspase-3 and caspase-9 activation[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0061 mL 10.0305 mL 20.0610 mL
5 mM 0.4012 mL 2.0061 mL 4.0122 mL
10 mM 0.2006 mL 1.0030 mL 2.0061 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay

Cells (5×105 cells/mL) are seeded in the 35-mm Petri dishes and cultured for 72 h at 37°C. Cells are pre-incubated with ALA, and then DIDS of diverse concentrations (0-200 μM) is added before exposed to ultrasound. Cell apoptosis is detected. Briefly, seeded cells (5×105 cells/mL) are pre-treated with test compounds at the indicated concentrations for 1 h (DIDS and NAC), 1.5 h (BAPTA) or with siRNA and exposed to ultrasound. Six hours after ALA-SDT treatment, cells are collected[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

498.48

Formula

C₁₆H₈N₂Na₂O₆S₄

CAS No.

67483-13-0

SMILES

O=S(C1=CC(N=C=S)=CC=C1/C=C/C2=CC=C(N=C=S)C=C2S(=O)([O-])=O)([O-])=O.[Na+].[Na+]

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
DIDS sodium salt
Cat. No.:
HY-D0086
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DIDS sodium salt

Cat. No.: HY-D0086