67483-13-0
Chemical Structure
DIDS sodium salt
Synonym(s): MDL101114ZA
- CAS No.: 67483-13-0
- Formula:C16H8N2Na2O6S4
- Molecular Weight:498.48
IUPAC Name: sodium (E)-6,6'-(ethene-1,2-diyl)bis(3-isothiocyanatobenzenesulfonate)
InChIKey: GEPAYBXVXXBSKP-SEPHDYHBSA-L
SMILES: O=S(C1=CC(N=C=S)=CC=C1/C=C/C2=CC=C(N=C=S)C=C2S(=O)(O[Na])=O)(O[Na])=O
Biological Activity: DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits RAD51, inhibiting RAD51-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DIDS sodium salt | 99.13% | DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits RAD51, inhibiting RAD51-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research. | ||||||||||||||||||||
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- [1]. Chen H, et al. Inhibition of VDAC1 prevents Ca²⁺-mediated oxidative stress and apoptosis induced by 5-aminolevulinic acid mediated sonodynamic therapy in THP-1 macrophages. Apoptosis. 2014 Dec;19(12):1712-26. [Content Brief]
- [2]. Tsou CY, et al. Activation of soluble guanylyl cyclase prevents foam cell formation and atherosclerosis. Acta Physiol (Oxf). 2014 Apr;210(4):799-810. [Content Brief]
Keywords
