2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Amsonic acid

Amsonic acid is an orally active weak estrogen receptor ligand with uterotrophic activity. In the weanling female rat model, Amsonic acid exhibits a uterotrophic effect consistent with that of diethylstilbestrol at equiactive doses. Amsonic acid can also be used in studies related to erectile dysfunction.

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Amsonic acid

Amsonic acid Chemical Structure

CAS No. : 28096-93-7

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Amsonic acid Related Antibodies

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Description

Amsonic acid is an orally active weak estrogen receptor ligand with uterotrophic activity. In the weanling female rat model, Amsonic acid exhibits a uterotrophic effect consistent with that of diethylstilbestrol at equiactive doses. Amsonic acid can also be used in studies related to erectile dysfunction[1].

In Vitro

Amsonic acid exhibits weak binding to estrogen receptors isolated from rabbit uteri, alongside other tested chemicals including 4-nitrotoluene, DNSDSA, and MNBSA[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Amsonic acid Related Antibodies
In Vivo

Amsonic acid (300-1000 mg/kg; i.p.; single dose; 1000-3000 mg/kg; p.o.; single dose) exhibits weak but distinct estrogenic uterotrophic activity in weanling female CD Sprague-Dawley rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD Sprague-Dawley Rat (female, weanling)[1]
Dosage: 0.1 mg/kg; 1 mg/kg; 10 mg/kg; 30 mg/kg; 100 mg/kg; 300 mg/kg; 1000 mg/kg; 3000 mg/kg (i.p.); 1000 mg/kg; 3000 mg/kg (p.o.)
Administration: i.p.; single dose; p.o.; single dose
Result: Caused no change in relative uterine weight at 0.1 and 1 mg/kg i.p..
Produced equivocal effects at 10, 30, and 100 mg/kg i.p., with only the 30 mg/kg dose showing a statistically significant 16% increase in relative uterine weight.
Induced a statistically significant 66% increase in relative uterine weight at 300 mg/kg i.p..
Caused a statistically significant 50% increase in relative uterine weight at 1000 mg/kg i.p., with no overt toxicity observed.
Resulted in toxicity at 3000 mg/kg i.p., with 2 out of 6 animals dying within 24 hours.
Produced distinct uterotropic responses with no toxicity at 1000 and 3000 mg/kg p.o..
Caused a statistically significant increase in relative uterine weight for a workplace sample at 300 mg/kg i.p., consistent with the commercial sample.
Showed a time course of uterine weight gain after 300 mg/kg i.p. similar to that of equiactive 0.01 mg/kg i.p. diethylstilbestrol, with a multiphasic response including an early and late phase.
Molecular Weight

370.40

Formula

C14H14N2O6S2
CAS No.
SMILES

O=S(O)(C1=C(C=CC(N)=C1)/C=C/C2=C(C=C(C=C2)N)S(=O)(O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Amsonic acid Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amsonic acid28096-93-7Estrogen Receptor/ERRDNSDSAMNBSAuterotropic agentCD Sprague-Dawley ratsweanling female rats4-nitrotolueneestrogen receptorrabbit uterisexual impotencediethylstilbestrolInhibitorinhibitorinhibit

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