1. Cell Cycle/DNA Damage
  2. RAD51
  3. RI-2

RI-2 

Cat. No.: HY-16904 Purity: 99.22%
Handling Instructions

RI-2 is a reversible RAD51 inhibitor, with an IC50 of 44.17 μM, and specifically inhibits homologous recombination repair in human cells.

For research use only. We do not sell to patients.

RI-2 Chemical Structure

RI-2 Chemical Structure

CAS No. : 1417162-36-7

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 220 In-stock
Estimated Time of Arrival: December 31
5 mg USD 200 In-stock
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10 mg USD 360 In-stock
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50 mg USD 900 In-stock
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100 mg USD 1650 In-stock
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Description

RI-2 is a reversible RAD51 inhibitor, with an IC50 of 44.17 μM, and specifically inhibits homologous recombination repair in human cells.

IC50 & Target

IC50: 44.17 μM (RAD51)[1]

In Vitro

RI-2 (7a) is a reversible RAD51 inhibitor, with an IC50 of 44.17 μM. RI-2 specifically inhibits homologous recombination repair in human cells. RI-2 (150 μM) induces a significant sensitization of cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

433.28

Formula

C₂₁H₁₈Cl₂N₂O₄

CAS No.

1417162-36-7

SMILES

O=C(C(C1=CC=C(OC)C=C1)=C2N3CCOCC3)N(C4=CC=C(Cl)C(Cl)=C4)C2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 15.5 mg/mL (35.77 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3080 mL 11.5399 mL 23.0798 mL
5 mM 0.4616 mL 2.3080 mL 4.6160 mL
10 mM 0.2308 mL 1.1540 mL 2.3080 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

HEK293 cells are plated into 96-well tissue culture plates at a density of 300 cells per well in the presence or absence of 50 nM mitomycin C (MMC) for 24 hours at 37°C, 5% CO2. Media is subsequently replaced with fresh media containing 0.5% DMSO plus RI-2 for an additional 24 hours. RI-2 is then removed, and cultures are allowed to grow to a 50-70% confluence. Average survival from at least three replicates is measured using CellGlo reagentor. RI-2 is deemed successful in sensitizing cells to MMC if they generate significantly greater toxicity in the presence of MMC relative to the absence of MMC. Specifically, sensitization is scored as a “+” when non-overlapping standard errors are observed for at least two pairs of compound doses[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

RI-2RI2RI 2RAD51Inhibitorinhibitorinhibit

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