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  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. TEF1/TEAD-1 Antibody (YA2122)

TEF1/TEAD-1 Antibody (YA2122)

Cat. No.: HY-P82377
User Guide for Antibodies Technical Support

TEF1/TEAD-1 Antibody (YA2122) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TEF1/TEAD-1.

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사이즈 가격 재고 수량
20 μL 견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL 견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL 견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   견적 받기  
Synthetic products have potential research and development risk.
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 제품 설명

제품 설명

TEF1/TEAD-1 Antibody (YA2122) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TEF1/TEAD-1.
Host

Rabbit
Clonality

Recombinant, Monoclonal
분자량
Predicted band size: 48 kDa;
Observed band size: 54 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human TEAD1 + TEAD2 + TEAD3 + TEAD4 aa150-300.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
선적

Shipping with blue ice.
Background
Function：Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif
Subcellular Localization：Nucleus
Expression：
Tissue_specificity:It is primarily expressed in skeletal muscle. Expression levels are lower in the pancreas, placenta, and heart.
Isoforms & Post-Translational Modification：P28347 has 2 isomers: P28347-1: 47946 Da (predicted); P28347-2: 40000 Da (predicted).
Lactylation by AARS1 promotes nuclear localization and stabilization of YAP1, leading to increased Hippo signaling pathway (PubMed:38512451). Delactylated by SIRT1 (PubMed:38512451)
Subunit：Interacts with YAP1 and WWTR1/TAZ
Database

Entrez Gene: 7003 Human

SwissProt: P28347 Human

OMIM: 108985 Human

Research Field

Epigenetics and Nuclear Signaling
Synonyms
DTEF 1; NTEF 1; TCF13; TEAD1; TEAD2; TEAD3; TEAD4; TEAD5; TEF1; TEF4; TEF5
각종 서류
User Guide for Antibodies (1077 KB)

TEF1/TEAD-1 Antibody (YA2122) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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상품명:
TEF1/TEAD-1 Antibody (YA2122)
Cat. No.:
HY-P82377
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