VT104

Name: VT104
Brand: MedChemExpress
SKU: HY-134956
Rating: 5.0 (3 reviews)

Cat. No.: HY-134956 Purity: 99.94%: Data Sheet
COA

SDS
Handling Instructions
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VT104 is a potent and orally active YAP/TAZ inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer.

For research use only. We do not sell to patients.

CAS No. : 2417718-25-1

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	Get quote
10 g	Get quote

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of VT104:

(R)-VT104 In-stock

3 Publications Citing Use of MCE VT104

Cell Proliferation/Viability Assay

RT-PCR

: VT104 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Sep 1.; Dose response curves of VT104 (0.001-10 μM) in SCEACono2 (ONO2) cells examined in proliferation assay and clonogenic assay.

: VT104 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Sep 1.; qPCR for YAP/TAZ-TEAD target genes upon treatment with VT104 (1 µM) for 24 hours in ONO2 cells in vitro (n=3).

: VT104 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Sep 1.; YAP co-immunoprecipitation experiment in ONO2 cells treated with VT104 (1µM) for 24 hours.

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YAP/TAZ YAP/TAZ-TEAD TEAD YAP1

Biological Activity
Purity & Documentation
References
Customer Review

Description

VT104 is a potent and orally active YAP/TAZ inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H226	IC₅₀	0.042 μM Compound: VT-104	Cytotoxicity against human NCI-H226 cells assessed as cell viability at 10 uM measured for 7 days by celltiter-glo assay Cytotoxicity against human NCI-H226 cells assessed as cell viability at 10 uM measured for 7 days by celltiter-glo assay	[PMID: 35763499]

In Vitro

VT104 (0-1000 nM) inhibits proliferation of NF2 mutant/defective cell line^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

VT104 (0.3-3 mg/kg; p.o.; NCI-H226-tumor bearing mice) blocks growth of NF2-deficient mesothelioma xenografts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NCI-H226-tumor bearing mice^[1]
Dosage:	0.3, 1, and 3 mg/kg
Administration:	Oral administration
Result:	Blocked NCI-H226 tumor growth in mice in dose-dependent manner.

Molecular Weight

420.43

Formula

C₂₅H₁₉F₃N₂O

CAS No.

2417718-25-1

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C2C(C3=CC=C(C(F)(F)F)C=C3)=CC=CC2=C1)N[C@H](C4=NC=CC=C4)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (237.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3785 mL	11.8926 mL	23.7852 mL
5 mM	0.4757 mL	2.3785 mL	4.7570 mL
10 mM	0.2379 mL	1.1893 mL	2.3785 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.94%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (252 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Tang TT, et, al. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021 Jun;20(6):986-998. [Content Brief]

[2]. Barry ER, et, al. Recent Therapeutic Approaches to Modulate the Hippo Pathway in Oncology and Regenerative Medicine. Cells. 2021 Oct 11;10(10):2715. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3785 mL	11.8926 mL	23.7852 mL	59.4629 mL
	5 mM	0.4757 mL	2.3785 mL	4.7570 mL	11.8926 mL
	10 mM	0.2379 mL	1.1893 mL	2.3785 mL	5.9463 mL
	15 mM	0.1586 mL	0.7928 mL	1.5857 mL	3.9642 mL
	20 mM	0.1189 mL	0.5946 mL	1.1893 mL	2.9731 mL
	25 mM	0.0951 mL	0.4757 mL	0.9514 mL	2.3785 mL
	30 mM	0.0793 mL	0.3964 mL	0.7928 mL	1.9821 mL
	40 mM	0.0595 mL	0.2973 mL	0.5946 mL	1.4866 mL
	50 mM	0.0476 mL	0.2379 mL	0.4757 mL	1.1893 mL
	60 mM	0.0396 mL	0.1982 mL	0.3964 mL	0.9910 mL
	80 mM	0.0297 mL	0.1487 mL	0.2973 mL	0.7433 mL
	100 mM	0.0238 mL	0.1189 mL	0.2379 mL	0.5946 mL

VT104 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VT1042417718-25-1VT 104VT-104YAPYes-associated proteinTEAD1TEAD3palmitoylationcancarInhibitorinhibitorinhibit

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VT104

Customer Review

Other Forms of VT104:

VT104 Related Antibodies

3 Publications Citing Use of MCE VT104

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All YAP Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

VT104 Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

VT104 Related Classifications

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Customer Review

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