2. Stem Cell/Wnt
  3. YAP
  4. VT102

VT102 is a TEAD1 inhibitor with a human IC50 of 391 nM. VT102 inhibits auto-palmitoylation, attenuates YAP/TEAD1 interaction, reduces expression of TEAD target genes, and inhibits YAP-mediated luciferase reporter activity. VT102 exerts weak cell growth inhibitory activity in cancer cells. VT102 can be used for the research of cancer.

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VT102

VT102 Estructura química

No. CAS : 1119382-90-9

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VT102 Related Antibodies

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YAP/TAZ YAP/TAZ-TEAD TEAD YAP1

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Descripciòn

VT102 is a TEAD1 inhibitor with a human IC50 of 391 nM. VT102 inhibits auto-palmitoylation, attenuates YAP/TEAD1 interaction, reduces expression of TEAD target genes, and inhibits YAP-mediated luciferase reporter activity. VT102 exerts weak cell growth inhibitory activity in cancer cells. VT102 can be used for the research of cancer[1].

IC50 & Target[1]

TEAD1

391 nM (IC50)

In Vitro

VT102 inhibits YAP-mediated luciferase activity in a reporter assay with an IC50 of 391 nM, blocks TEAD1 auto-palmitoylation, reduces TEAD target gene expression, disrupts YAP/TEAD1 interactions in NCI-H2373 cell lysate, and shows weak growth inhibition in NCI-H2052 cells with an IC50 of 2030 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VT102 Related Antibodies
Peso molecular

470.39

Fòrmula

C21H20BrN5OS
No. CAS
SMILES

O=C(C1=CC(N=C(N(C)C)N2C3=CC=C(C=C3)Br)=C2S1)NC(C)C4=NC=CC=C4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

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VT102 Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

VT1021119382-90-9VT 102VT-102YAPYes-associated proteinYAP/TEAD1 interactionTEAD1cancer cellsNCI-H2052 cellsNCI-H2373 cell lysateYAP-mediated luciferase reporter activityTEAD target genesauto-palmitoylationInhibitorinhibitorinhibit

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Nombre del producto:
VT102
Cat. No.:
HY-182673
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