1119382-90-9
1119382-90-9
Chemical Structure
VT102
- CAS No.: 1119382-90-9
- Formula:C21H20BrN5OS
- Molecular Weight:470.39
InChIKey: GEZFEGZKOFUYHY-UHFFFAOYSA-N
SMILES: O=C(C1=CC(N=C(N(C)C)N2C3=CC=C(C=C3)Br)=C2S1)NC(C)C4=NC=CC=C4
Biological Activity: VT102 is a TEAD1 inhibitor with a human IC50 of 391 nM. VT102 inhibits auto-palmitoylation, attenuates YAP/TEAD1 interaction, reduces expression of TEAD target genes, and inhibits YAP-mediated luciferase reporter activity. VT102 exerts weak cell growth inhibitory activity in cancer cells. VT102 can be used for the research of cancer[1].
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VT102 | VT102 is a TEAD1 inhibitor with a human IC50 of 391 nM. VT102 inhibits auto-palmitoylation, attenuates YAP/TEAD1 interaction, reduces expression of TEAD target genes, and inhibits YAP-mediated luciferase reporter activity. VT102 exerts weak cell growth inhibitory activity in cancer cells. VT102 can be used for the research of cancer. | |||||||||||||||||||||
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References
Keywords
