IAP ligand 6 

IAP ligand 6 (A250) is an IAP ligand with a K_a value of 0.1 μM for the human XIAP BIR3 domain. IAP ligand 6 binds to the XIAP BIR3 domain and serves as an alkynylpyridine scaffold for the preparation of TEAD degraders that recruit IAP. IAP ligand 6 is applicable to research related to mesothelioma^[1].

IAP ligand 6 (A250) (500-0.8 nM, 10 μM-1.5 nM) binds with high affinity to cIAP1-BIR3, and moderate affinity to XIAP-BIR2 and XIAP-BIR3 domains in a cell-free SPR assay^[1].
IAP ligand 6 (A250) (10 μM-5 nM; 1 h at room temperature) specifically binds to cIAP1-BIR3 and XIAP-BIR3 domains in a competitive cell-free TR-FRET assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

286.35

C₁₄H₁₄N₄OS

CN[C@H](C(NC1=CC=CC(C#CC2=CN=CS2)=N1)=O)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Gupta N, et al. Expanding the toolbox to develop IAP-based degraders of TEAD transcription factors. Commun Chem. 2026;9(1):69. Published 2026 Jan 19.  [Content Brief]