2. PROTAC Stem Cell/Wnt
  3. PROTACs YAP
  4. PROTAC TEAD degrader-2

PROTAC TEAD degrader-2 (Compound 31) is an efficient TEAD1 PROTAC degrader with a DC50 of 0.6 nM. PROTAC TEAD degrader-2 inhibits the YAP/TAZ-TEAD interaction, with a IC50 of 1.8 nM. PROTAC TEAD degrader-2 exhibits significant selective inhibitory activity against YAP-dependent cancer cells and effectively suppresses the transcriptional activity mediated by YAP. PROTAC TEAD degrader-2 can be used for research on mesothelioma and glioma.
(Pink: TEAD1 ligand (HY-186022); Blue: Cereblon ligand (HY-122725); Black: linker (HY-76199)).

For research use only. We do not sell to patients.

PROTAC TEAD degrader-2

PROTAC TEAD degrader-2 Chemical Structure

CAS No. : 2918762-17-9

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

PROTAC TEAD degrader-2 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All YAP Isoform Specific Products:

View All Isoforms
YAP/TAZ YAP/TAZ-TEAD TEAD YAP1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PROTAC TEAD degrader-2 (Compound 31) is an efficient TEAD1 PROTAC degrader with a DC50 of 0.6 nM. PROTAC TEAD degrader-2 inhibits the YAP/TAZ-TEAD interaction, with a IC50 of 1.8 nM. PROTAC TEAD degrader-2 exhibits significant selective inhibitory activity against YAP-dependent cancer cells and effectively suppresses the transcriptional activity mediated by YAP. PROTAC TEAD degrader-2 can be used for research on mesothelioma and glioma[1]. (Pink: TEAD1 ligand (HY-186022); Blue: Cereblon ligand (HY-122725); Black: linker (HY-76199)).

IC50 & Target[1]

TEAD1

0.6 nM (DC50)

YAP/TAZ-TEAD

1.8 nM (IC50)

Molecular Weight

896.42

Formula

C49H52ClF2N5O7
CAS No.
SMILES

O=C(C1=[C@@]([C@@]2=C3[C@H](C)[C@](C4=CC=CC=C4)(CN[C@@H]5CC[C@H](CC5)C(NCCCCCC(C=CC=C67)=C7CN(C8C(NC(CC8)=O)=O)C6=O)=O)OC3=CC(F)=C2Cl)C(F)=C(OC)C=C1)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

PROTAC TEAD degrader-2 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC TEAD degrader-22918762-17-9PROTAC TEAD degrader2PROTAC TEAD degrader 2PROTACsYAPYes-associated proteinYAP/TAZ-TEAD inhibitorPROTACTEAD degradationprotein-protein interactioncancer therapyHippo pathwayubiquitin-proteasome systembiochemical assaycellular proliferationluciferase reporter assayInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PROTAC TEAD degrader-2
Cat. No.:
HY-186021
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.