PROTAC TEAD degrader-2
PROTAC TEAD degrader-2 (Compound 31) is an efficient TEAD1 PROTAC degrader with a DC50 of 0.6 nM. PROTAC TEAD degrader-2 inhibits the YAP/TAZ-TEAD interaction, with a IC50 of 1.8 nM. PROTAC TEAD degrader-2 exhibits significant selective inhibitory activity against YAP-dependent cancer cells and effectively suppresses the transcriptional activity mediated by YAP. PROTAC TEAD degrader-2 can be used for research on mesothelioma and glioma.
(Pink: TEAD1 ligand (HY-186022); Blue: Cereblon ligand (HY-122725); Black: linker (HY-76199)).
For research use only. We do not sell to patients.
- CAS No.: 2918762-17-9
- Formula: C49H52ClF2N5O7
- Molecular Weight:896.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TEAD1 0.6 nM (DC50) |
YAP/TAZ-TEAD 1.8 nM (IC50) |
Chemical Information
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CAS No. 2918762-17-9
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Molecular Weight 896.42
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Formula C49H52ClF2N5O7
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SMILES
O=C(C1=[C@@]([C@@]2=C3[C@H](C)[C@](C4=CC=CC=C4)(CN[C@@H]5CC[C@H](CC5)C(NCCCCCC(C=CC=C67)=C7CN(C8C(NC(CC8)=O)=O)C6=O)=O)OC3=CC(F)=C2Cl)C(F)=C(OC)C=C1)N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC TEAD degrader-2 Related Classifications
HY-186021 Related Classifications
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- PROTAC TEAD degrader-2
- 2918762-17-9
- PROTAC TEAD degrader2
- PROTAC TEAD degrader 2
- PROTACs
- YAP
- YAP/TAZ-TEAD inhibitor
- PROTAC
- TEAD degradation
- protein-protein interaction
- cancer therapy
- Hippo pathway
- ubiquitin-proteasome system
- biochemical assay
- cellular proliferation
- luciferase reporter assay
- Inhibitor
- inhibitor
- inhibit