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Cat. No.: HY-169316

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YAP/TAZ inhibitor-4

YAP/TAZ inhibitor-4 (Compound 45) is an inhibitor of YAP/TAZ, exhibiting TEAD transcriptional activation inhibitory activity by suppressing the binding of YAP or TAZ to TEAD.

For research use only. We do not sell to patients.

Formula: C₂₈H₂₈F₃N₃O₃
Molecular Weight:511.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

YAP/TAZ inhibitor-4 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

YAP/TAZ inhibitor-4 (Compound 45) is an inhibitor of YAP/TAZ, exhibiting TEAD transcriptional activation inhibitory activity by suppressing the binding of YAP or TAZ to TEAD^[1].

IC₅₀ & Target

YAP/TAZ

YAP/TAZ-TEAD

All YAP Isoforms :

In Vitro

YAP/TAZ Inhibitor-4 (Compound 45) (100 pM-1 μM; 24 h) inhibits the transcriptional activity of TEAD in MCF7 cells, with an IC₅₀ value of 0.15 μM against TEAD receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 511.54
Formula C₂₈H₂₈F₃N₃O₃
SMILES

NC(CC[C@@H](C1=CC=CC(OC)=C1)NC(N2CCC3=C(C2)C=CC=C3C4=CC=C(C=C4)C(F)(F)F)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kim Yong-chan, et al. Heterobicyclic compound and pharmaceutical composition comprising same. Patent. WO2024210578, 2024-10-10.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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YAP/TAZ inhibitor-4

All YAP Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

YAP/TAZ inhibitor-4 Related Classifications

HY-169316 Related Classifications