1. Stem Cell/Wnt
  2. YAP
  3. YAP-TEAD-IN-1

YAP-TEAD-IN-1 

Cat. No.: HY-P2244
Handling Instructions

YAP-TEAD-IN-1 is a potent and competitive inhibitor of YAP–TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd=40 nM).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

YAP-TEAD-IN-1 Chemical Structure

YAP-TEAD-IN-1 Chemical Structure

CAS No. : 1659305-78-8

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other In-stock Forms of YAP-TEAD-IN-1:

Other Forms of YAP-TEAD-IN-1:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

YAP-TEAD-IN-1 is a potent and competitive inhibitor of YAP–TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd=40 nM)[1].

IC50 & Target

IC50: 25 nM (YAP–TEAD interaction)[1]

In Vitro

YAP-TEAD-IN-1 (peptide 17)(2 μM) is against endogenous YAP binding to GST-TEAD (1209-426) in a GST pull-down assay, the Kd of His-YAP1209-426 is determined to be 40 nM[1].

Molecular Weight

2019.86

Formula

C₉₃H₁₄₄ClN₂₃O₂₁S₂

CAS No.

1659305-78-8

Sequence

Ac-{Val}{Pro}{Phe(3-Cl)}{Hcy}{Leu}{Arg}{Lys}{Nle}{Pro}{Ala}{Ser}{Phe}{Cys}{Lys}{Pro}{Pro}{Glu}-NH2 (Disulfide bridge:Hcy4-Cys13)

Sequence Shortening

Ac-VP-{Phe(3-Cl)}-{Hcy}-LRK-{Nle}-PASFCKPPE-NH2 (Disulfide bridge:Hcy4-Cys13)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

YAP-TEAD-IN-1YAPYes-associated proteinYAP–TEADinteractionpeptidePPIInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
YAP-TEAD-IN-1
Cat. No.:
HY-P2244
Quantity:
MCE Japan Authorized Agent: