1. Stem Cell/Wnt
  2. YAP
  3. YAP-TEAD-IN-1 TFA

YAP-TEAD-IN-1 TFA 

Cat. No.: HY-P2244A Purity: 99.88%
Handling Instructions

YAP-TEAD-IN-1 TFA is a potent and competitive peptide inhibitor of YAP-TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 TFA is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd= 40 nM).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

YAP-TEAD-IN-1 TFA Chemical Structure

YAP-TEAD-IN-1 TFA Chemical Structure

CAS No. : 1659305-79-9

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1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 540 In-stock
Estimated Time of Arrival: December 31
10 mg USD 910 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

YAP-TEAD-IN-1 TFA is a potent and competitive peptide inhibitor of YAP-TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 TFA is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd= 40 nM)[1].

IC50 & Target

IC50: 25 nM (YAP-TEAD interaction)[1]

In Vitro

YAP-TEAD-IN-1 (peptide 17)(2 μM) is against endogenous YAP binding to GST-TEAD(1209-426) in a GST pull-down assay, the Kd of His-YAP(1209-426) is determined to be 40 nM[1].

Formula

C₉₃H₁₄₄ClN₂₃O₂₁S₂.xC₂HF₃O₂

CAS No.

1659305-79-9

Sequence

Ac-{Val}{Pro}{Phe(3-Cl)}{Hcy}{Leu}{Arg}{Lys}{Nle}{Pro}{Ala}{Ser}{Phe}{Cys}{Lys}{Pro}{Pro}{Glu}-NH2 (Disulfide bridge:Hcy4-Cys13)

Sequence Shortening

Ac-VP-{Phe(3-Cl)}-{Hcy}-LRK-{Nle}-PASFCKPPE-NH2 (Disulfide bridge:Hcy4-Cys13)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

YAP-TEAD-IN-1YAPYes-associated proteinYAP–TEADinteractionpeptidePPIInhibitorinhibitorinhibit

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YAP-TEAD-IN-1 TFA
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