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Cat. No.: HY-161443

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TEAD-IN-9

TEAD-IN-9 (compound 17) is a TEAD1 inhibitor with an IC₅₀ of 0.29 μM. TEAD-IN-9 targets the palmitoyl pocket of TEAD, thereby effectively inhibiting the binding of YAP-TEAD and blocking the transcriptional function of YAP-TEAD.

For research use only. We do not sell to patients.

Formula: C₂₃H₂₃F₃N₃O₃P
Molecular Weight:477.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

TEAD-IN-9 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

TEAD1

0.29 μM (IC₅₀)

All YAP Isoforms :

In Vivo

Pharmacokinetic Analysis in SD rats^[1]

Route	Dose (mg/kg)	C_max (ng/mL)	T_max (h)	AUC_0-t (ng·h/mL)	AUC_0-∞ (ng·h/mL)	V_ss (L/kg)	Cl (L/h/kg)	MRT_0-t (h)	MRT_0-∞ (h)	t_1/2 (h)	F (%)
i.g.	10	1477	0.5	4662	5688	/	/	2.84	4.66	3.46	51.9
i.v.	1	598	/	899	924	1.947	1.082	1.55	1.80	1.94	51.9

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 477.42
Formula C₂₃H₂₃F₃N₃O₃P
SMILES

O=P(C)(C)C1=CC=C(NCC2=CC=C(C(F)(F)F)C=C2)C(C3=NC(OC4COC4)=CC=N3)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dong Liu. Small molecule compound having phosphorylated aryl structure, and use thereof. WO2024061366A1.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration Concentration

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Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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