TEAD-IN-9
TEAD-IN-9 (compound 17) is a TEAD1 inhibitor with an IC50 of 0.29 μM. TEAD-IN-9 targets the palmitoyl pocket of TEAD, thereby effectively inhibiting the binding of YAP-TEAD and blocking the transcriptional function of YAP-TEAD.
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- Fòrmula: C23H23F3N3O3P
- Peso molecular:477.42
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
IC50 & Target
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TEAD1 0.29 μM (IC50) |
In Vivo
Pharmacokinetic Analysis in SD rats[1]
| Route | Dose (mg/kg) | Cmax (ng/mL) | Tmax (h) | AUC0-t (ng·h/mL) | AUC0-∞ (ng·h/mL) | Vss (L/kg) | Cl (L/h/kg) | MRT0-t (h) | MRT0-∞ (h) | t1/2 (h) | F (%) |
| i.g. | 10 | 1477 | 0.5 | 4662 | 5688 | / | / | 2.84 | 4.66 | 3.46 | 51.9 |
| i.v. | 1 | 598 | / | 899 | 924 | 1.947 | 1.082 | 1.55 | 1.80 | 1.94 | 51.9 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 477.42
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Fòrmula C23H23F3N3O3P
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SMILES
O=P(C)(C)C1=CC=C(NCC2=CC=C(C(F)(F)F)C=C2)C(C3=NC(OC4COC4)=CC=N3)=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TEAD-IN-9 Related Classifications
HY-161443 Related Classifications
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