TEAD-IN-9
TEAD-IN-9 (compound 17) is a TEAD1 inhibitor with an IC50 of 0.29 μM. TEAD-IN-9 targets the palmitoyl pocket of TEAD, thereby effectively inhibiting the binding of YAP-TEAD and blocking the transcriptional function of YAP-TEAD.
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- 화학식: C23H23F3N3O3P
- 분자량:477.42
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
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Biological Activity
제품 설명
IC50 & Target
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TEAD1 0.29 μM (IC50) |
In Vivo
Pharmacokinetic Analysis in SD rats[1]
| Route | Dose (mg/kg) | Cmax (ng/mL) | Tmax (h) | AUC0-t (ng·h/mL) | AUC0-∞ (ng·h/mL) | Vss (L/kg) | Cl (L/h/kg) | MRT0-t (h) | MRT0-∞ (h) | t1/2 (h) | F (%) |
| i.g. | 10 | 1477 | 0.5 | 4662 | 5688 | / | / | 2.84 | 4.66 | 3.46 | 51.9 |
| i.v. | 1 | 598 | / | 899 | 924 | 1.947 | 1.082 | 1.55 | 1.80 | 1.94 | 51.9 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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분자량 477.42
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화학식 C23H23F3N3O3P
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SMILES
O=P(C)(C)C1=CC=C(NCC2=CC=C(C(F)(F)F)C=C2)C(C3=NC(OC4COC4)=CC=N3)=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TEAD-IN-9 Related Classifications
HY-161443 Related Classifications
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