PROTAC TEAD1/IAP degrader-3

PROTAC TEAD1/IAP degrader-3 is a TEAD1/IAP PROTAC degrader. PROTAC TEAD1/IAP degrader-3 recruits the cIAP1 and XIAP E3 ligases to form a ternary complex, drives proteasomal degradation of TEAD1, and triggers autoubiquitination and proteasomal degradation of cIAP1. PROTAC TEAD1/IAP degrader-3 inhibits cell proliferation. PROTAC TEAD1/IAP degrader-3 regulates Hippo pathway activity by downregulating CTGF gene expression in a TEAD-dependent manner. PROTAC TEAD1/IAP degrader-3 is applicable to the research of mesothelioma.
(Pink: TEAD1 ligand (HY-181592); Blue: IAP ligand (HY-181591); Black: linker).

For research use only. We do not sell to patients.

  • Formula: C47H50F4N6O6
  • Molecular Weight:870.93
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

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