MGRN1 - mahogunin ring finger 1 Gene

Also Known as RNF156

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23295

About MGRN1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,624,826-4,690,972 (from NCBI)

This gene has 18 transcripts (splice variants), 219 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 8.9), brain (RPKM 8.4) and 25 other tissues.

Summary

Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin Ligase activity in vitro.[supplied by OMIM, Apr 2004]

MGRN1 Products (4)

mRNA Protein Name
NM_001142289.3 NP_001135761.2 E3 ubiquitin-protein ligase MGRN1 isoform 2
NM_001142290.3 NP_001135762.1 E3 ubiquitin-protein ligase MGRN1 isoform 3
NM_001142291.3 NP_001135763.2 E3 ubiquitin-protein ligase MGRN1 isoform 4
NM_015246.4 NP_056061.1 E3 ubiquitin-protein ligase MGRN1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17229889 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
17229889 GOA
Biological Process GO Annotation Evidence References Source
involved in endosome to lysosome transport IMP
IMP: Inferred from mutant phenotype
17229889 GOA
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
19737927 GOA
involved in protein monoubiquitination IMP
IMP: Inferred from mutant phenotype
17229889 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17229889 GOA
located in early endosome IDA
IDA: Inferred from direct assay
17229889 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17229889 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
19737927 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MGRN1 Protein Structure

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (275 - 321)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 552 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase MGRN1

  • RING finger protein 156

MGRN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MGRN1 O60291 TSG101 Homo sapiens Q99816
Y2H Prey Pooling
25416956
Intra
MGRN1 O60291 TSG101 Homo sapiens Q99816
Y2H Array
19549727
Intra
MGRN1 O60291 TSG101 Homo sapiens Q99816
Validated Y2H
25416956
Intra
MGRN1 O60291 TSG101 Homo sapiens Q99816
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Gerstmann-Straussler Disease

  • Gerstmann-Straussler-Scheinker Disease

  • Gerstmann-Straussler-Scheinker Syndrome

  • Prion Dementia

  • Cerebral Amyloid Angiopathy, Prnp-Related

  • GSD

  • Gss

  • Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In Cns

  • Amyloidosis, Cerebral, With Spongiform Encephalopathy

  • Subacute Spongiform Encephalopathy, Gerstmann-Straussler Type

  • Encephalopathy, Subacute Spongiform, Gerstmann-Straussler Type

  • Amyloidosis Cerebral With Spongiform Encephalopathy

  • Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In The Central Nervous System

  • Encephalopathy Subacute Spongiform Gerstmann-Straussler Type

  • Gssd

  • Gerstmann Straussler Scheinker Syndrome

  • Cerebral Amyloidosis With Spongiform Encephalopathy

  • Subacute Spongiform Encephalopathy Gerstmann-Straussler Type

  • Gluthathione Synthetase Deficiency

  • Gerstmann Straussler Syndrome
Visceral Heterotaxy

  • Situs Ambiguus

  • Heterotaxia

  • Heterotaxy Syndrome

  • Heterotaxy

  • Lateralization Defect

  • Situs Ambiguous

  • Left Isomerism

  • Htx

  • Ivemark Syndrome

  • Right Isomerism

  • Situs Ambiguus Viscerum

  • Incomplete Situs Inversus

  • Partial Situs Inversus

  • Heterotaxy, Visceral

  • Asplenia Syndrome

  • Bilateral Left-Sidedness

  • Polysplenia Syndrome

  • Moller Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08415 MGRN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MGRN1 VGNC VGNC:43214
Rattus norvegicus MGRN1 RGD RGD:1311862
Bos taurus MGRN1 VGNC VGNC:97285
Mus musculus MGRN1 MGD MGI:2447670
Macaca mulatta MGRN1 VGNC VGNC:74542
Felis catus MGRN1 VGNC VGNC:63491
Others MGRN1 NCBI