CBY1 - chibby family member 1, beta catenin antagonist Gene

Also Known as CBY; arb1; PGEA1; C22orf2; Chibby1; PIGEA14; PIGEA-14; HS508I15A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25776

About CBY1

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,656,638-38,673,850 (from NCBI)

This gene has 10 transcripts (splice variants), 188 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in prostate (RPKM 16.6), adrenal (RPKM 16.3) and 25 other tissues.

Summary

Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CBY1 Products (2)

mRNA Protein Name
NM_001002880.4 NP_001002880.3 protein chibby homolog 1
NM_015373.4 NP_056188.1 protein chibby homolog 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-catenin binding IDA
IDA: Inferred from direct assay
12712206 GOA
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
16424001 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
15194699 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15194699 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
21182262 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12712206 GOA
involved in negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
12712206 GOA
involved in protein homotetramerization IDA
IDA: Inferred from direct assay
21182262 GOA
involved in protein localization IMP
IMP: Inferred from mutant phenotype
15194699 GOA
Cellular Component GO Annotation Evidence References Source
located in centriole IDA
IDA: Inferred from direct assay
22911743 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12712206 GOA
located in trans-Golgi network IDA
IDA: Inferred from direct assay
15194699 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CBY1 Protein Structure

Chibby

Chibby: Chibby family (1 - 117)

  • 0
  • 100
  • 126 a.a.
Protein Preferred Names Protein Names

protein chibby homolog 1

  • ARPP-binding protein

CBY1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CBY1 Q9Y3M2 TTC23L Homo sapiens Q6PF05-3
Y2H Array
25416956
Intra
CBY1 Q9Y3M2 DZIP1L Homo sapiens Q8IYY4
Anti Tag CoIP
33961781
Intra
CBY1 Q9Y3M2 CIBAR1 Homo sapiens A1XBS5
Anti Tag CoIP
33961781
Intra
CBY1 Q9Y3M2 CIBAR1 Homo sapiens A1XBS5
Y2H Prey Pooling
25416956
Intra
CBY1 Q9Y3M2 CIBAR1 Homo sapiens A1XBS5
Y2H Array
25416956
Intra
CBY1 Q9Y3M2 YWHAZ Homo sapiens P63104
Anti Tag CoIP
33961781
Intra
CBY1 Q9Y3M2 YWHAZ Homo sapiens P63104
CoIP
18573912
Intra
CBY1 Q9Y3M2 YWHAE Homo sapiens P62258
TAP
27173435
Intra
CBY1 Q9Y3M2 YWHAE Homo sapiens P62258
CoIP
18573912
Intra
CBY1 Q9Y3M2 CFAP53 Homo sapiens Q96M91
Lumier
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

CBY1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810074 Chibby Antibody (YA9418) WB, ICC/IF, IF-Tissue, IP, ELISA human

Related Diseases

Diseases Alias
Joubert Syndrome 1

  • Joubert Syndrome

  • Jbts

  • Cerebellooculorenal Syndrome 1

  • JBTS1

  • Joubert-Boltshauser Syndrome

  • Cerebelloparenchymal Disorder Iv

  • Cpd4

  • Cors1

  • Joubert Syndrome And Related Disorders

  • Jsrd

  • Familial Aplasia Of The Vermis

  • Joubert Syndrome Related Disorders

  • Js

  • Cerebellar Vermis Agenesis

  • Cerebelloparenchymal Disorder 4

  • Agenesis Of Cerebellar Vermis

  • Cerebello-Oculo-Renal Syndrome

  • Cors

  • Joubert-Bolthauser Syndrome

  • Cpd Iv

  • Classic Joubert Syndrome

  • Joubert Syndrome Type A

  • Pure Joubert Syndrome

  • Cerebello-Oculo-Renal Syndrome 1

  • Joubert Syndrome-1

  • Joubert Syndrome, Type 1

  • Joubert'S Syndrome
Ulcerative Blepharitis
Macular Degeneration, Age-Related, 9

  • Age Related Macular Degeneration 9

  • ARMD9

  • Macular Degeneration, Age-Related, 9, Susceptibility To

  • Macular Degeneration, Age-Related, Type 9
Granulomatous Orchitis

  • Non-Specific Granulomatous Orchitis
Myringitis Bullosa Hemorrhagica

  • Bullous Myringitis
Macular Degeneration, Age-Related, 14

  • Age Related Macular Degeneration 14

  • ARMD14

  • Macular Degeneration, Age-Related, 14, Reduced Risk Of

  • Macular Degeneration, Age-Related, Type 14
Nephronophthisis

  • Medullary Cystic Disease

  • Medullary Cystic Kidney

  • Nph

  • Nphp

  • Kidney Disease, Cystic, Medullary
Primary Ciliary Dyskinesia

  • Immotile Cilia Syndrome

  • Kartagener Syndrome

  • Dextrocardia Bronchiectasis And Sinusitis

  • Pcd

  • Ciliary Motility Disorders

  • Ciliary Motility Disorder

  • Immotile Ciliary Syndrome

  • Ciliary Dyskinesia Primary

  • Ics

  • Polynesian Bronchiectasis

  • Dextrocardia-Bronchiectasis-Sinusitis Syndrome

  • Immotile Cilia Syndrome, Kartagener Type

  • Primary Ciliary Dyskinesia And Situs Inversus

  • Primary Ciliary Dyskinesia, Kartagener Type

  • Siewert Syndrome

  • Dyskinesia, Ciliary, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02016 CBY1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CBY1 VGNC VGNC:26822
Mus musculus CBY1 MGD MGI:1920989
Felis catus CBY1 VGNC VGNC:60427
Canis familiaris CBY1 VGNC VGNC:38770
Macaca mulatta CBY1 VGNC VGNC:107103
Rattus norvegicus CBY1 RGD RGD:708481
Others CBY1 NCBI