CBY1 - chibby family member 1, beta catenin antagonist Gene

Homo sapiens

Also known as CBY; arb1; PGEA1; C22orf2; Chibby1; PIGEA14; PIGEA-14; HS508I15A

Gene ID: 25776 | Gene type: protein coding

About CBY1

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,656,638-38,673,850 (from NCBI)

This gene has 10 transcripts (splice variants), 188 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in prostate (RPKM 16.6), adrenal (RPKM 16.3) and 25 other tissues.

Summary

Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CBY1 Products(2)

mRNA	Protein	Name
NM_001002880.4	NP_001002880.3	protein chibby homolog 1
NM_015373.4	NP_056188.1	protein chibby homolog 1

CBY1 Protein Structure

Chibby

0
100
126 a.a.

Protein Preferred Names

Protein Names

protein chibby homolog 1

ARPP-binding protein

Related Diseases

Diseases

Alias

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Ulcerative Blepharitis

Macular Degeneration, Age-Related, 9

Age Related Macular Degeneration 9	ARMD9
Macular Degeneration, Age-Related, 9, Susceptibility To	Macular Degeneration, Age-Related, Type 9

Granulomatous Orchitis

Non-Specific Granulomatous Orchitis

Myringitis Bullosa Hemorrhagica

Bullous Myringitis

Macular Degeneration, Age-Related, 14

Age Related Macular Degeneration 14	ARMD14
Macular Degeneration, Age-Related, 14, Reduced Risk Of	Macular Degeneration, Age-Related, Type 14

Nephronophthisis

Medullary Cystic Disease	Medullary Cystic Kidney
Nph	Nphp
Kidney Disease, Cystic, Medullary

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02016	CBY1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CBY1	VGNC	VGNC:26822
Mus musculus	CBY1	MGD	MGI:1920989
Felis catus	CBY1	VGNC	VGNC:60427
Canis familiaris	CBY1	VGNC	VGNC:38770
Macaca mulatta	CBY1	VGNC	VGNC:107103
Rattus norvegicus	CBY1	RGD	RGD:708481