2. Gene
  3. TOM1L1 - target of myb1 like 1 membrane trafficking protein Gene

TOM1L1 - target of myb1 like 1 membrane trafficking protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SRCASM

Gene ID: 10040 | Gene type: protein coding

About TOM1L1

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:54,900,852-54,961,956 (from NCBI)

This gene has 23 transcripts (splice variants), 152 orthologues and 10 paralogues. Broad expression in duodenum (RPKM 37.8), thyroid (RPKM 25.7) and 24 other tissues.

Summary

Enables clathrin binding activity and protein kinase binding activity. Involved in negative regulation of mitotic nuclear division; positive regulation of protein phosphorylation; and signal transduction. Located in cytosol and endosome. [provided by Alliance of Genome Resources, Apr 2022]

TOM1L1 Products(5)

mRNA Protein Name
NM_001321173.2 NP_001308102.1 TOM1-like protein 1 isoform 2
NM_001321174.2 NP_001308103.1 TOM1-like protein 1 isoform 3
NM_001321175.2 NP_001308104.1 TOM1-like protein 1 isoform 3
NM_001321176.2 NP_001308105.1 TOM1-like protein 1 isoform 3
NM_005486.3 NP_005477.2 TOM1-like protein 1 isoform 1

TOM1L1 Protein Structure

VHS

VHS: VHS domain (12 - 150)

GAT

GAT: GAT domain (199 - 292)

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  • 476 a.a.
Protein Preferred Names Protein Names

TOM1-like protein 1

src-activating and signaling molecule protein

Related Diseases

Diseases Alias
Nodular Basal Cell Carcinoma

Basal Cell Carcinoma, Nodular

Circumscribed Solid Basal Cell Carcinoma

Skin Nodulo-Ulcerative Basal Cell Carcinoma

Skin Solid Basal Cell Carcinoma

Skin Nodular Basal Cell Carcinoma

Skin Nodular Solid Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Circumscribed Solid Basal Cell Carcinoma Of Skin
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14877 TOM1L1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TOM1L1 VGNC VGNC:36218
Canis familiaris TOM1L1 VGNC VGNC:47708
Rattus norvegicus TOM1L1 RGD RGD:1562626
Mus musculus TOM1L1 MGD MGI:1919193
Felis catus TOM1L1 VGNC VGNC:97667
Macaca mulatta TOM1L1 VGNC VGNC:78616