VAV2 - vav guanine nucleotide exchange factor 2 Gene

Homo sapiens

Also known as VAV-2

Gene ID: 7410 | Gene type: protein coding

About VAV2

Cytogenetic location: 9q34.2 Genomic coordinates (GRCh38): 9:133,761,894-133,992,324 (from NCBI)

This gene has 5 transcripts (splice variants), 209 orthologues and 22 paralogues. Ubiquitous expression in adrenal (RPKM 10.2), small intestine (RPKM 8.2) and 25 other tissues.

Summary

VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

VAV2 Products(3)

mRNA	Protein	Name
NM_001134398.2	NP_001127870.1	guanine nucleotide exchange factor VAV2 isoform 1
NM_001411028.1	NP_001397957.1	guanine nucleotide exchange factor VAV2 isoform 3
NM_003371.4	NP_003362.2	guanine nucleotide exchange factor VAV2 isoform 2

VAV2 Protein Structure

CAMSAP_CH

RhoGEF

C1_1

SH3_2

SH2

SH3_2

0
200
400
600
800
878 a.a.

Protein Preferred Names

Protein Names

guanine nucleotide exchange factor VAV2

vav 2 oncogene

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12810	EHop-016	Inhibitor	99.85%	Unkown
HY-RS15613	VAV2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	VAV2	VGNC	VGNC:78758
Felis catus	VAV2	VGNC	VGNC:66926
Mus musculus	VAV2	MGD	MGI:102718
Rattus norvegicus	VAV2	RGD	RGD:1306285
Canis familiaris	VAV2	VGNC	VGNC:58344
Bos taurus	VAV2	VGNC	VGNC:36773

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