VAV2 - vav guanine nucleotide exchange factor 2 Gene

Also Known as VAV-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7410

About VAV2

Cytogenetic location: 9q34.2 Genomic coordinates (GRCh38): 9:133,761,894-133,992,324 (from NCBI)

This gene has 5 transcripts (splice variants), 209 orthologues and 22 paralogues. Ubiquitous expression in adrenal (RPKM 10.2), small intestine (RPKM 8.2) and 25 other tissues.

Summary

VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

VAV2 Products (3)

mRNA Protein Name
NM_001134398.2 NP_001127870.1 guanine nucleotide exchange factor VAV2 isoform 1
NM_001411028.1 NP_001397957.1 guanine nucleotide exchange factor VAV2 isoform 3
NM_003371.4 NP_003362.2 guanine nucleotide exchange factor VAV2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity EXP
EXP: Inferred from Experiment
8990121 GOA
enables phosphotyrosine residue binding IPI
IPI: Inferred from physical interaction
20624904 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11390470 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of GTPase activity IGI
IGI: Inferred from genetic interaction
22467863 GOA
NOT involved in regulation of cell size IGI
IGI: Inferred from genetic interaction
22467863 GOA
involved in regulation of cell size IGI
IGI: Inferred from genetic interaction
22467863 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VAV2 Protein Structure

CAMSAP_CH

CAMSAP_CH: CAMSAP CH domain (19 - 103)

RhoGEF

RhoGEF: RhoGEF domain (202 - 375)

PH

PH: PH domain (408 - 511)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (524 - 571)

SH3_2

SH3_2: Variant SH3 domain (591 - 650)

SH2

SH2: SH2 domain (673 - 747)

SH3_2

SH3_2: Variant SH3 domain (826 - 874)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 878 a.a.
Protein Preferred Names Protein Names

guanine nucleotide exchange factor VAV2

  • vav 2 oncogene

VAV2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
VAV2 P52735 NEK3 Homo sapiens P51956
CoIP
15618286
Intra
VAV2 P52735 GAB1 Homo sapiens Q13480
FPS
24728074
Intra
VAV2 P52735 CAV1 Homo sapiens Q03135
Anti Bait CoIP
20808760
Intra
VAV2 P52735 ERBB2 Homo sapiens P04626
Protein Array
16273093
Intra
VAV2 P52735 TOM1L1 Homo sapiens O75674
Anti Tag CoIP
18654987
Intra
VAV2 P52735 SH3BP2 Homo sapiens P78314
Pull Down
11390470
Intra
VAV2 P52735 SH3BP2 Homo sapiens P78314
Y2H
15345594
Intra
VAV2 P52735 SH3BP2 Homo sapiens P78314
Pull Down
15345594
Intra
VAV2 P52735 SH3BP2 Homo sapiens P78314
Anti Tag CoIP
15345594
Cross: Cross-species interaction Intra: Intraspecies interaction

VAV2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83567 VAV2 Antibody (YA3312) WB, IHC-P, ICC/IF, FC, IP Human, Mouse, Rat
HY-P83567A VAV2 Antibody (YA3312)(PBS only) WB, IHC-P, ICC/IF, FC, IP Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12810 EHop-016 Inhibitor 99.38% Unkown
HY-RS15613 VAV2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22354 Vav2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28876 Vav2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta VAV2 VGNC VGNC:78758
Felis catus VAV2 VGNC VGNC:66926
Mus musculus VAV2 MGD MGI:102718
Rattus norvegicus VAV2 RGD RGD:1306285
Canis familiaris VAV2 VGNC VGNC:58344
Bos taurus VAV2 VGNC VGNC:36773
Others VAV2 NCBI