NEK3 - NIMA related kinase 3 Gene

Also Known as HSPK36

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4752

About NEK3

Cytogenetic location: 13q14.3 Genomic coordinates (GRCh38): 13:52,132,647-52,159,597 (from NCBI)

This gene has 11 transcripts (splice variants), 191 orthologues and 8 paralogues. Broad expression in testis (RPKM 10.8), placenta (RPKM 6.5) and 24 other tissues.

Summary

This gene encodes a member of the NimA (never in Mitosis A) family of serine/threonine protein kinases. The encoded protein differs from Other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by Prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Two functional alleles for this gene have been identified in humans. The reference genome assembly (GRCh38) represents a functional allele that is associated with the inclusion of an additional coding exon in protein-coding transcripts, compared to an alternate functional allele that lacks the exon. [provided by RefSeq, Sep 2019]

NEK3 Products (3)

mRNA Protein Name
NM_001146099.1 NP_001139571.1 serine/threonine-protein kinase Nek3 isoform b
NM_002498.3 NP_002489.1 serine/threonine-protein kinase Nek3 isoform a
NM_152720.3 NP_689933.1 serine/threonine-protein kinase Nek3 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15618286 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEK3 Protein Structure

Pkinase

Pkinase: Protein kinase domain (26 - 274)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 510 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase Nek3

  • HSPK 36

NEK3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NEK3 P51956 VAV2 Homo sapiens P52735
CoIP
15618286
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Glycogen Storage Disease Ia

  • Von Gierke Disease

  • Glycogen Storage Disease Type I

  • Glycogen Storage Disease I

  • Hepatorenal Form Of Glycogen Storage Disease

  • Hepatorenal Glycogenosis

  • Glucose-6-Phosphatase Deficiency

  • Glycogen Storage Disease, Type I

  • Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ia

  • GSD1A

  • Gsd1

  • Von Gierke'S Disease

  • Glycogen Storage Disease Type 1a

  • Glycogen Storage Disease 1a

  • Glucose-6-Phosphate Transport Defect

  • Gsd Ia

  • Deficiency Of Glucose-6-Phosphatase

  • Glycogenosis Type I

  • Glucose-6-Phosphatase Deficiency Glycogen Storage Disease

  • Glycogenosis Type 1

  • Glucose-6-Phosphate Deficiency

  • Gsd I

  • Gsd Type I

  • G6p Deficiency Type 1a

  • Gsd Due To G6p Deficiency Type 1a

  • Gsd Due To G6p Deficiency Type Ia

  • Gsd Type 1a

  • Gsdia

  • Glycogen Storage Disease Due To G6p Deficiency Type Ia

  • Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type 1a

  • Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type Ia

  • Glycogenosis Type Ia

  • Gsd-Ia

  • Storage Disease, Glycogen, Type 1a

  • Glycogen Storage Disease Type Ia
Glycogen Storage Disease

  • Glycogenosis

  • Glycogenoses

  • Gsd

  • Storage Disease, Glycogen

  • Gsd - [Glycogen Storage Disease]

  • Glycogen Thesaurismosis

  • Diffuse Glycogenosis

  • Generalised Glycogen Storage Disease

  • Generalised Glycogenosis

  • Generalised Glycogen Storage Disease Of Infants

  • Glycogen Synthase Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09194 NEK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20306 Nek3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26814 Nek3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NEK3 VGNC VGNC:31994
Rattus norvegicus NEK3 RGD RGD:1307419
Mus musculus NEK3 MGD MGI:1344371
Felis catus NEK3 VGNC VGNC:68457
Macaca mulatta NEK3 VGNC VGNC:75309
Others NEK3 NCBI