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VAV2 Antibody (YA3312)

(Synonyms: VAV2; Vav 2 oncogene; VAV-2)
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VAV2 Antibody (YA3312) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VAV2.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IHC-P, ICC/IF, FC, IP

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

  • Conjugation:
    Non-conjugated
  • VAV2 Antibody (YA3312) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
FC Info
FC: Flow Cytometry
IP Info
IP: Immunoprecipitation
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
Dilution Ratio 1:1000-1:5000 1:100-1:200 1:200-1:1000 1:20 1:50-1:100

Product Details

Description

VAV2 Antibody (YA3312) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VAV2.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 101 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 101 kDa
Species Reactivity Database

Entrez Gene: 7410 Human

SwissProt: P52735 Human

Immunogen

A synthetic peptide of human VAV2

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    VAV2 is a Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly

  • Expression


    Tissue_specificity:Widely expressed

  • Isoforms & Post-Translational Modification

    P52735 has 3 isomers: P52735-1: 101289 Da (predicted); P52735-2: 100057 Da (predicted); P52735-3: 97032 Da (predicted).
    Phosphorylated on tyrosine residues in response to FGR activation

  • Subunit

    Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with SSX2IP (By similarity). Interacts with NEK3 and PRLR and this interaction is prolactin-dependent

  • SwissProt ID

    P52735

  • Gene ID
    7410 [NCBI]
  • Synonyms

    VAV2; Vav 2 oncogene; VAV-2

  • Research Field

    Signal Transduction

VAV2 Antibody (YA3312) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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