VAV2 Antibody (YA3312)(PBS only)
(Synonyms: VAV2; Vav 2 oncogene; VAV-2)VAV2 Antibody (YA3312) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VAV2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, FC, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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IP
IP: Immunoprecipitation
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|---|---|
| Dilution Ratio | 1:1000-1:5000 | 1:100-1:200 | 1:200-1:1000 | 1:20 | 1:50-1:100 |
Product Details
VAV2 Antibody (YA3312) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VAV2.
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Host Rabbit
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 101 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 101 kDa
A synthetic peptide of human VAV2
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
VAV2 is a Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly
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Expression
Tissue_specificity:Widely expressed -
Isoforms & Post-Translational Modification
P52735 has 3 isomers: P52735-1: 101289 Da (predicted); P52735-2: 100057 Da (predicted); P52735-3: 97032 Da (predicted).
Phosphorylated on tyrosine residues in response to FGR activation -
Subunit
Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with SSX2IP (By similarity). Interacts with NEK3 and PRLR and this interaction is prolactin-dependent
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SwissProt ID
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Synonyms
VAV2; Vav 2 oncogene; VAV-2
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Research Field
Signal Transduction
Documentation
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