IQGAP1 - IQ motif containing GTPase activating protein 1 Gene

Homo sapiens

Also known as SAR1; p195; HUMORFA01

Gene ID: 8826 | Gene type: protein coding

About IQGAP1

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:90,388,242-90,502,239 (from NCBI)

This gene has 18 transcripts (splice variants), 217 orthologues and 2 paralogues. Ubiquitous expression in colon (RPKM 49.8), appendix (RPKM 48.4) and 25 other tissues.

Summary

This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the Cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric Cancer cell lines. [provided by RefSeq, Jul 2008]

IQGAP1 Products(1)

mRNA	Protein	Name
NM_003870.4	NP_003861.1	ras GTPase-activating-like protein IQGAP1

IQGAP1 Protein Structure

RasGAP

RasGAP_C

0
300
600
900
1200
1500
1657 a.a.

Protein Preferred Names

Protein Names

ras GTPase-activating-like protein IQGAP1

RasGAP-like with IQ motifs

Related Diseases

Diseases

Alias

Nephrotic Syndrome, Type 3

NPHS3	Nephrotic Syndrome Type 3
Nephrotic Syndrome, Early-Onset, Type 3	Early Onset Nephrotic Syndrome Type 3
Nephrotic Syndrome 3	Early-Onset Nephrotic Syndrome Type 3

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06885	IQGAP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IQGAP1	VGNC	VGNC:73755
Bos taurus	IQGAP1	VGNC	VGNC:30258
Mus musculus	IQGAP1	MGD	MGI:1352757
Canis familiaris	IQGAP1	VGNC	VGNC:42081
Felis catus	IQGAP1	VGNC	VGNC:67817
Rattus norvegicus	IQGAP1	RGD	RGD:1311884

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