RAB11FIP2 - RAB11 family interacting protein 2 Gene

Also Known as nRip11; Rab11-FIP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22841

Summary

Enables protein homodimerization activity and protein kinase binding activity. Involved in several processes, including TRAM-dependent Toll-like Receptor 4 signaling pathway; phagocytosis; and positive regulation of GTPase activity. Located in endosome and phagocytic cup. [provided by Alliance of Genome Resources, Jun 2026]
Ubiquitous expression in endometrium (RPKM 12.0), brain (RPKM 9.2) and 25 other tissues.

RAB11FIP2 Products (2)

mRNA Protein Name
NM_001330167.2 NP_001317096.1 rab11 family-interacting protein 2 isoform 2
NM_014904.3 NP_055719.1 rab11 family-interacting protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16905101 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12470645 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
16905101 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
16775013 GOA
Biological Process GO Annotation Evidence References Source
involved in TRAM-dependent toll-like receptor 4 signaling pathway IDA
IDA: Inferred from direct assay
30883606 GOA
involved in establishment of cell polarity IMP
IMP: Inferred from mutant phenotype
16775013 GOA
involved in phagocytosis IMP
IMP: Inferred from mutant phenotype
30883606 GOA
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
30883606 GOA
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
16905101 GOA
located in phagocytic cup IDA
IDA: Inferred from direct assay
30883606 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB11FIP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RAB11FIP2 Q7L804 RAB11A Homo sapiens P62491
Anti Tag CoIP
17082457
Intra
RAB11FIP2 Q7L804 RAB11A Homo sapiens P62491
Y2H Array
32296183
Intra
RAB11FIP2 Q7L804 RAB11A Homo sapiens P62491
Ion Exchange Chrom
16905101
Intra
RAB11FIP2 Q7L804 RAB11A Homo sapiens P62491
X-Ray Diffraction
16905101
Intra
RAB11FIP2 Q7L804 RAB11A Homo sapiens P62491
Y2H Prey Pooling
32296183
Intra
RAB11FIP2 Q7L804 RAB11A Homo sapiens P62491
Y2H
16905101
Intra
RAB11FIP2 Q7L804 YWHAG Homo sapiens P61981
CoIP
15324660
Intra
RAB11FIP2 Q7L804 RAB25 Homo sapiens P57735
Y2H Prey Pooling
32296183
Intra
RAB11FIP2 Q7L804 RAB25 Homo sapiens P57735
Y2H Array
32296183
Intra
RAB11FIP2 Q7L804 FBXO17 Homo sapiens Q96EF6
Validated Y2H
32296183
Intra
RAB11FIP2 Q7L804 YWHAE Homo sapiens P62258
Y2H Array
32296183
Intra
RAB11FIP2 Q7L804 YWHAE Homo sapiens P62258
Y2H Prey Pooling
32296183
Intra
RAB11FIP2 Q7L804 FAM90A1 Homo sapiens Q86YD7
Validated Y2H
32296183
Intra
RAB11FIP2 Q7L804 RAB11B Homo sapiens Q15907
Y2H Array
32296183
Intra
RAB11FIP2 Q7L804 RAB11B Homo sapiens Q15907
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11517 RAB11FIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11518 RAB11FIP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11519 RAB11FIP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11520 RAB11FIP5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown