VTA1 - vesicle trafficking 1 Gene

Homo sapiens

Also known as DRG1; LIP5; SBP1; DRG-1; My012; 6orf55; C6orf55; HSPC228

Gene ID: 51534 | Gene type: protein coding

About VTA1

Cytogenetic location: 6q24.1-q24.2 Genomic coordinates (GRCh38): 6:142,147,263-142,224,685 (from NCBI)

This gene has 5 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in brain (RPKM 16.7), colon (RPKM 13.5) and 25 other tissues.

Summary

C6ORF55 encodes a protein involved in trafficking of the multivesicular body, an endosomal compartment involved in sorting membrane proteins for degradation in lysosomes (Ward et al., 2005 [PubMed 15644320]).[supplied by OMIM, Mar 2008]

VTA1 Products(3)

mRNA	Protein	Name
NM_001286371.2	NP_001273300.1	vacuolar protein sorting-associated protein VTA1 homolog isoform b
NM_001286372.2	NP_001273301.1	vacuolar protein sorting-associated protein VTA1 homolog isoform c
NM_016485.5	NP_057569.2	vacuolar protein sorting-associated protein VTA1 homolog isoform a

VTA1 Protein Structure

Vta1

0
100
200
307 a.a.

Protein Preferred Names

Protein Names

vacuolar protein sorting-associated protein VTA1 homolog

LYST-interacting protein 5

Related Diseases

Diseases

Alias

Arthrogryposis, Distal, Type 1b

DA1B	Distal Arthrogryposis Type 1b
Arthrogryposis, Distal, 1b

Arthrogryposis, Distal, Type 1a

Distal Arthrogryposis Type 1	Digitotalar Dysmorphism
DA1A	Da1
Amcd1	Arthrogryposis, Distal, Type 2b4
Distal Arthrogryposis Type 1a	Arthrogryposis, Distal, Type 1
Arthrogryposis Multiplex Congenita Distal Type 1	Arthrogryposis Multiplex Congenita, Distal Type 1
Arthrogryposis Multiplex Congenita, Distal, Type I	Distal Arthrogryposis Type 1b
Arthrogryposis, Distal, 1a	Amc
Arthrogryposis Multiplex Congenita	Arthrogryposis, Distal, 2b4
DA2B4	Arthrogryposis Multiplex Congenita, Distal, Type 1
Arthrogryposis

Meckel Syndrome, Type 6

Meckel Syndrome 6	MKS6
Meckel-Gruber Syndrome, Type 6

Malignant Choroid Melanoma

Malignant Melanoma Of Choroid

Melanoma Of The Choroid

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148502	VU6019650	Antagonist	98.61%	Unkown
HY-RS15720	VTA1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	VTA1	VGNC	VGNC:36847
Mus musculus	VTA1	MGD	MGI:1913451
Felis catus	VTA1	VGNC	VGNC:66987
Canis familiaris	VTA1	VGNC	VGNC:48314
Rattus norvegicus	VTA1	RGD	RGD:1305031
Macaca mulatta	VTA1	VGNC	VGNC:79296

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