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Cat. No.: HY-122883

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BC-1471

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

BC-1471 is a STAMBP deubiquitinase inhibitor with an IC₅₀ of 0.33 μM. BC-1471 can inhibit the activity of the NALP7 inflammasome. BC-1471 has anti-inflammatory activity and can be used for the research of inflammatory diseases.

For research use only. We do not sell to patients.

Purity: 99.69%
CAS No.: 896683-84-4
Formula: C₂₇H₃₂N₄O₄S
Molecular Weight:508.63

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

BC-1471 Chemical Structure

CAS No.: 896683-84-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

IL-1β

Caspase-1

All Deubiquitinase Isoforms :

All Interleukin Related Isoforms :

All Caspase Isoforms :

In Vitro

BC-1471 (0.1-10 μM; 6-8 h) reduces LPS (HY-D1056) or Pam3CSK4 (HY-P1180)-induced NALP7 protein levels and caspase-1 activation in THP-1 cells^[1].
BC-1471 (0-10 μM; 4 h) inhibits LPS (HY-D1056) or Pam3CSK4 (HY-P1180)-induced IL-1β release in human PBMCs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

LPS (HY-D1056) or Pam3CSK4 (HY-P1180) treated THP-1 cells
Concentration:

0.1, 1 and 10 μM
Incubation Time:

6 h
Result:

Inhibited the protein levels of NALP7.

Chemical Information

CAS No. 896683-84-4
Appearance Solid
Molecular Weight 508.63
Formula C₂₇H₃₂N₄O₄S
Color White to off-white
SMILES

O=C(NCC1OCCC1)CSC(N2CCC3=CC=CC=C3)=NC4=C(C=C(N5CCOCC5)C=C4)C2=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Res Sq

2025 Dec 18.

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (98.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9661 mL

9.8303 mL

19.6607 mL

5 mM

0.3932 mL

1.9661 mL

3.9321 mL

10 mM

0.1966 mL

0.9830 mL

1.9661 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bednash JS, et al. Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity. Nat Commun. 2017 May 11;8:15203. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9661 mL	9.8303 mL	19.6607 mL	49.1516 mL
	5 mM	0.3932 mL	1.9661 mL	3.9321 mL	9.8303 mL
	10 mM	0.1966 mL	0.9830 mL	1.9661 mL	4.9152 mL
	15 mM	0.1311 mL	0.6554 mL	1.3107 mL	3.2768 mL
	20 mM	0.0983 mL	0.4915 mL	0.9830 mL	2.4576 mL
	25 mM	0.0786 mL	0.3932 mL	0.7864 mL	1.9661 mL
	30 mM	0.0655 mL	0.3277 mL	0.6554 mL	1.6384 mL
	40 mM	0.0492 mL	0.2458 mL	0.4915 mL	1.2288 mL
	50 mM	0.0393 mL	0.1966 mL	0.3932 mL	0.9830 mL
	60 mM	0.0328 mL	0.1638 mL	0.3277 mL	0.8192 mL
	80 mM	0.0246 mL	0.1229 mL	0.2458 mL	0.6144 mL

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo Dissolution Calculator
Purity & Documentation
References

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BC-1471

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Immunology/Inflammation Compound Library

Anti-Aging Compound Library

Differentiation Inducing Compound Library

Ubiquitination Compound Library

Pyroptosis Compound Library

Angiogenesis-Related Compound Library

Heterocyclic Compound Library

Metabolic Enzyme Compound Library

Protease Inhibitor Library

Cytokine Inhibitors Library

Inflammasomes related Compound Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Publications Citing Use of MedChemExpress (MCE) BC-1471

All Deubiquitinase Isoforms

All Interleukin Related Isoforms

All Caspase Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

BC-1471

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Immunology/Inflammation Compound Library

Anti-Aging Compound Library

Differentiation Inducing Compound Library

Ubiquitination Compound Library

Pyroptosis Compound Library

Angiogenesis-Related Compound Library

Heterocyclic Compound Library

Metabolic Enzyme Compound Library

Protease Inhibitor Library

Cytokine Inhibitors Library

Inflammasomes related Compound Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Publications Citing Use of MedChemExpress (MCE) BC-1471

All Deubiquitinase Isoforms

All Interleukin Related Isoforms

All Caspase Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

BC-1471 Related Classifications

Cat. No.: HY-122883