TEKT1 - tektin 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83659

About TEKT1

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:6,797,993-6,831,729 (from NCBI)

This gene has 5 transcripts (splice variants), 194 orthologues and 5 paralogues. Restricted expression toward testis (RPKM 17.1).

Summary

This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is predominantly expressed in the testis and in mouse, tektin 1 mRNA was localized to the spermatocytes and round spermatids in the seminiferous tubules, indicating that it may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

TEKT1 Products (1)

mRNA Protein Name
NM_053285.2 NP_444515.1 tektin-1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence References Source
located in axonemal microtubule IDA
IDA: Inferred from direct assay
36191189 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TEKT1 Protein Structure

Tektin

Tektin: Tektin family (16 - 398)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 418 a.a.
Protein Preferred Names Protein Names

tektin-1

TEKT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TEKT1 Q969V4 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
TEKT1 Q969V4 CCHCR1 Homo sapiens Q8TD31-3
Y2H Array
25416956
Intra
TEKT1 Q969V4 NCAPD3 Homo sapiens Q96FA6
Validated Y2H
25416956
Intra
TEKT1 Q969V4 NCAPD3 Homo sapiens Q96FA6
Y2H Array
25416956
Intra
TEKT1 Q969V4 NCAPD3 Homo sapiens Q96FA6
Y2H Prey Pooling
25416956
Intra
TEKT1 Q969V4 UNC45A Homo sapiens Q9H3U1
Validated Y2H
32296183
Intra
TEKT1 Q969V4 PRKAG1 Homo sapiens P54619
Y2H Array
25416956
Intra
TEKT1 Q969V4 C1orf74 Homo sapiens Q96LT6
Validated Y2H
32296183
Intra
TEKT1 Q969V4 CHD2 Homo sapiens O14647
Validated Y2H
25416956
Intra
TEKT1 Q969V4 CHD2 Homo sapiens O14647
Y2H Array
25416956
Intra
TEKT1 Q969V4 HNRNPH2 Homo sapiens P55795
Validated Y2H
25416956
Intra
TEKT1 Q969V4 BYSL Homo sapiens Q13895
Y2H Prey Pooling
25416956
Intra
TEKT1 Q969V4 VCL Homo sapiens P18206
Validated Y2H
25416956
Intra
TEKT1 Q969V4 VCL Homo sapiens P18206
Y2H Prey Pooling
25416956
Intra
TEKT1 Q969V4 SDCBP Homo sapiens O00560
Y2H Array
25416956
Intra
TEKT1 Q969V4 SDCBP Homo sapiens O00560
Y2H Prey Pooling
25416956
Intra
TEKT1 Q969V4 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
TEKT1 Q969V4 NME7 Homo sapiens Q9Y5B8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Adult Spinal Cord Ependymoma
Ehlers-Danlos Syndrome, Kyphoscoliotic Type, 1

  • Nevo Syndrome

  • Eds Vi

  • Ehlers-Danlos Syndrome, Type Vi

  • Eds Via

  • Ehlers-Danlos Syndrome Type 6

  • EDSKSCL1

  • Eds6

  • Ehlers-Danlos Syndrome Kyphoscoliotic Type 1

  • Kyphoscoliotic Ehlers-Danlos Syndrome

  • Cutis Hyperelastica

  • Ehlers-Danlos Syndrome Type 6a

  • Ehlers-Danlos Syndrome Oculoscoliotic Type

  • Kyphoscoliotic Eds

  • Kyphoscoliotic Eds Due To Lysyl Hydroxylase 1 Deficiency

  • Kyphoscoliotic Ehlers-Danlos Syndrome Due To Lysyl Hydroxylase 1 Deficiency

  • Lysyl Hydroxylase-Deficient Eds

  • Ocular-Scoliotic Eds

  • Keds

  • Keds-Plod1

  • Ehlers-Danlos Syndrome, Kyphoscoliotic Type 1

  • Ehlers-Danlos Syndrome, Ocular-Scoliotic Type

  • Ehlers-Danlos Syndrome, Type Via, Formerly

  • Eds6a, Formerly

  • Eds 6

  • Eds, Kyphoscoliotic Type

  • Eds, Oculoscoliotic Type

  • Ehlers-Danlos Syndrome, Kyphoscoliosis Type

  • Ehlers-Danlos Syndrome, Kyphoscoliotic Type

  • Ehlers-Danlos Syndrome, Oculoscoliotic Type

  • Eds6a

  • Ehlers-Danlos Syndrome 6

  • Ehlers-Danlos Syndrome Kyphoscoliotic Type
Brain Ependymoma

  • Ependymal Tumor Of Brain

  • Ependymoma Of Brain
Spondyloepimetaphyseal Dysplasia, Sponastrime Type

  • Sponastrime Dysplasia

  • Spondylar And Nasal Alterations With Striated Metaphyses

  • SEMDSP

  • Short-Limb Dwarfism With Saddle Nose, Spinal Alterations, And Metaphyseal Striation

  • Spondylar And Nasal Alterations-Striated Metaphyses Syndrome

  • Spondyloepimetaphyseal Dysplasia Sponastrime Type

  • Short Limb Dwarfism With Saddle Nose, Spinal Alterations, And Metaphyseal Striation

  • Spondylar And Nasal Changes With Striations Of The Metaphyses Dysplasia

  • Short Limb Dwarfism With Saddle Nose, Spinal Alterations And Metaphyseal Striation

  • Dysplasia, Spondyloepimetaphyseal, Sponastrime Type
Primary Ciliary Dyskinesia

  • Immotile Cilia Syndrome

  • Kartagener Syndrome

  • Dextrocardia Bronchiectasis And Sinusitis

  • Pcd

  • Ciliary Motility Disorders

  • Ciliary Motility Disorder

  • Immotile Ciliary Syndrome

  • Ciliary Dyskinesia Primary

  • Ics

  • Polynesian Bronchiectasis

  • Dextrocardia-Bronchiectasis-Sinusitis Syndrome

  • Immotile Cilia Syndrome, Kartagener Type

  • Primary Ciliary Dyskinesia And Situs Inversus

  • Primary Ciliary Dyskinesia, Kartagener Type

  • Siewert Syndrome

  • Dyskinesia, Ciliary, Primary
Visceral Heterotaxy

  • Situs Ambiguus

  • Heterotaxia

  • Heterotaxy Syndrome

  • Heterotaxy

  • Lateralization Defect

  • Situs Ambiguous

  • Left Isomerism

  • Htx

  • Ivemark Syndrome

  • Right Isomerism

  • Situs Ambiguus Viscerum

  • Incomplete Situs Inversus

  • Partial Situs Inversus

  • Heterotaxy, Visceral

  • Asplenia Syndrome

  • Bilateral Left-Sidedness

  • Polysplenia Syndrome

  • Moller Syndrome
Epilepsy, Myoclonic Juvenile

  • Juvenile Myoclonic Epilepsy

  • Janz Syndrome

  • Jme

  • Myoclonic Epilepsy, Juvenile, Susceptibility To, 1

  • EJM

  • Myoclonic Epilepsy, Juvenile

  • Petit Mal, Impulsive

  • Myoclonic Epilepsy, Juvenile 1

  • Myoclonic Epilepsy, Juvenile, 1

  • Adolescent Myoclonic Epilepsy

  • Juvenile Myoclonus Epilepsy

  • Juvenile Myoclonic Epilepsy 1

  • EJM1

  • Petit Mal Impulsive

  • Susceptibility To Juvenile Myoclonic Epilepsy 1

  • Myoclonic Epilepsy Juvenile

  • Epilepsy, Myoclonic, Juvenile

  • Myoclonic Epilepsy Of Janz

  • Jme - [Juvenile Myoclonic Epilepsy]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14356 TEKT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22853 Tekt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29367 Tekt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TEKT1 VGNC VGNC:78387
Felis catus TEKT1 VGNC VGNC:66065
Rattus norvegicus TEKT1 RGD RGD:619913
Bos taurus TEKT1 VGNC VGNC:35736
Mus musculus TEKT1 MGD MGI:1333819
Canis familiaris TEKT1 VGNC VGNC:47242
Others TEKT1 NCBI