HNRNPH2 - heterogeneous nuclear ribonucleoprotein H2 Gene

Also Known as FTP3; MRXSB; NRPH2; HNRPH'; HNRPH2; hnRNPH'

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3188

About HNRNPH2

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:101,408,222-101,414,133 (from NCBI)

This gene has 1 transcript (splice variant), 130 orthologues, 8 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 50.7), adrenal (RPKM 42.7) and 25 other tissues.

Summary

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and Other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabray disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein. Read-through transcription between this locus and the ribosomal protein L36a gene has been observed. [provided by RefSeq, Jan 2011]

HNRNPH2 Products (2)

mRNA	Protein	Name
NM_001032393.3	NP_001027565.1	heterogeneous nuclear ribonucleoprotein H2
NM_019597.5	NP_062543.1	heterogeneous nuclear ribonucleoprotein H2

HNRNPH2 Protein Structure

zf-RNPHF

0
100
200
300
400
449 a.a.

Protein Preferred Names	Protein Names
heterogeneous nuclear ribonucleoprotein H2	FTP-3

HNRNPH2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HNRNPH2	P55795	TEKT1	Homo sapiens	Q969V4	Y2H Array	32296183
Intra	HNRNPH2	P55795	TEKT1	Homo sapiens	Q969V4	Y2H Prey Pooling	25416956
Intra	HNRNPH2	P55795	TEKT1	Homo sapiens	Q969V4	Y2H Prey Pooling	32296183
Intra	HNRNPH2	P55795	TEKT1	Homo sapiens	Q969V4	Validated Y2H	32296183
Intra	HNRNPH2	P55795	TEKT1	Homo sapiens	Q969V4	Y2H Array	25416956
Intra	HNRNPH2	P55795	CCNK	Homo sapiens	O75909-2	Y2H Array	32296183
Intra	HNRNPH2	P55795	CCNK	Homo sapiens	O75909-2	Y2H Prey Pooling	32296183
Intra	HNRNPH2	P55795	MSI2	Homo sapiens	Q96DH6	Y2H Prey Pooling	32296183
Intra	HNRNPH2	P55795	MSI2	Homo sapiens	Q96DH6	Validated Y2H	25416956
Intra	HNRNPH2	P55795	MSI2	Homo sapiens	Q96DH6	Validated Y2H	32296183
Intra	HNRNPH2	P55795	MSI2	Homo sapiens	Q96DH6	Y2H Array	32296183
Intra	HNRNPH2	P55795	PLOD1	Homo sapiens	Q02809	Anti Tag CoIP	28514442
Intra	HNRNPH2	P55795	PLOD1	Homo sapiens	Q02809	Anti Tag CoIP	26496610
Intra	HNRNPH2	P55795	PLOD1	Homo sapiens	Q02809	Anti Tag CoIP	33961781
Intra	HNRNPH2	P55795	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	HNRNPH2	P55795	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	HNRNPH2	P55795	MSI1	Homo sapiens	O43347	Y2H Prey Pooling	32296183
Intra	HNRNPH2	P55795	MSI1	Homo sapiens	O43347	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, X-Linked, Syndromic, Bain Type	MRXSB Mental Retardation, X-Linked, Syndromic, Bain Type Intellectual Developmental Disorder, X-Linked Syndromic, Bain Type
Bain Type Of X-Linked Syndromic Intellectual Disability	Intellectual Disability, X-Linked, Syndromic, Bain Type Hnrnph2 Deficiency
Motor Stereotypies	Motor Stereotypy
Stereotypic Movement Disorder	Stereotypy Habit Disorder Stereotyped Repetitive Movements Stereotyped Disorder Stereotypes Nos Stereotype Habit Disorder
Syndromic X-Linked Intellectual Disability 94	Mrx94 Mrxs29 Syndromic X-Linked Intellectual Disability Due To Gria3 Anomalies Syndromic X-Linked Mental Retardation 29 Syndromic X-Linked Mental Retardation Wu Type
Agammaglobulinemia	Hypogammaglobulinemia Ighm Mu Heavy Chain Deficiency Mu-Heavy Chain Disease Mu-Hcd Mu-Chain Disease
Myotonic Disease	Myotonic Disorders Myotonic Syndrome Symptomatic Myotonia
Deafness, Autosomal Recessive 109	DFNB109 Autosomal Recessive Nonsyndromic Deafness 109 Autosomal Recessive Deafness 109 Deafness, Autosomal Recessive, 109
Myotonic Dystrophy 2	Myotonic Dystrophy Type 2 Proximal Myotonic Myopathy Promm Ricker Syndrome DM2 Dystrophia Myotonica 2 Myotonic Myopathy, Proximal Myotonic Disorders Dystrophia Myotonica Type 2 Proximal Myotonic Dystrophy Ricker Disease Myotonic Dystrophy, Type 2 Dystrophy, Myotonic, Type 2
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Myotonic Dystrophy 1	Myotonic Dystrophy Dystrophia Myotonica Steinert Disease Myotonic Dystrophy Type 1 Myotonia Atrophica DM1 Congenital Myotonic Dystrophy Myotonia Dystrophica Steinert Myotonic Dystrophy Dystrophia Myotonica 1 Dm Steinert'S Disease Steinert Myotonic Dystrophy Syndrome Myotonic Dystrophy Of Steinert Dystrophia Myotonica Type 1 Myotonic Dystrophy Congenital Dystrophy, Myotonic, Type 1 Dm - [Dystrophia Myotonica] Myotonic Muscular Dystrophy
Spinocerebellar Ataxia 8	Spinocerebellar Ataxia Type 8 SCA8 Ataxia, Spinocerebellar, Type 8
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1	FTDALS1 Frontotemporal Dementia And/Or Motor Neuron Disease Ftdmnd Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia Alsftd Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1 Frontotemporal Dementia With Motor Neuron Disease Ftdals Ftd-Als Ftd-Mnd Frontotemporal Dementia With Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1 Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1 Frontotemporal Lobar Degeneration Grn-Related Frontotemporal Dementia
Congenital Myasthenic Syndrome	Congenital Myasthenia Congenital Myasthenic Syndromes Cms Myasthenic Syndromes, Congenital Myasthenic Syndromes Congenital Myasthenic Syndrome, Congenital Congenital Myasthenic Syndrome Ib Congenital And Developmental Myasthenia Developmental Myasthenia
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06271	HNRNPH2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HNRNPH2	VGNC	VGNC:67608
Bos taurus	HNRNPH2	VGNC	VGNC:50192
Rattus norvegicus	HNRNPH2	RGD	RGD:1549784
Canis familiaris	HNRNPH2	VGNC	VGNC:41731
Mus musculus	HNRNPH2	MGD	MGI:1201779
Macaca mulatta	HNRNPH2	VGNC	VGNC:110582
Others	HNRNPH2	NCBI