MSI1 - musashi RNA binding protein 1 Gene

Homo sapiens

Gene ID: 4440 | Gene type: protein coding

About MSI1

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,339,662-120,369,164 (from NCBI)

This gene has 3 transcripts (splice variants), 286 orthologues, 36 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 2.5), brain (RPKM 2.0) and 14 other tissues.

Summary

This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008]

MSI1 Products(15)

mRNA	Protein	Name
NM_001414485.1	NP_001401414.1	RNA-binding protein Musashi homolog 1 isoform b
NM_001414486.1	NP_001401415.1	RNA-binding protein Musashi homolog 1 isoform c
NM_001414487.1	NP_001401416.1	RNA-binding protein Musashi homolog 1 isoform d
NM_001414488.1	NP_001401417.1	RNA-binding protein Musashi homolog 1 isoform e
NM_001414489.1	NP_001401418.1	RNA-binding protein Musashi homolog 1 isoform f
NM_001414490.1	NP_001401419.1	RNA-binding protein Musashi homolog 1 isoform g
NM_001414491.1	NP_001401420.1	RNA-binding protein Musashi homolog 1 isoform h
NM_001414492.1	NP_001401421.1	RNA-binding protein Musashi homolog 1 isoform i
NM_001414493.1	NP_001401422.1	RNA-binding protein Musashi homolog 1 isoform j
NM_001414494.1	NP_001401423.1	RNA-binding protein Musashi homolog 1 isoform j
NM_001414495.1	NP_001401424.1	RNA-binding protein Musashi homolog 1 isoform j
NM_001414496.1	NP_001401425.1	RNA-binding protein Musashi homolog 1 isoform k
NM_001414497.1	NP_001401426.1	RNA-binding protein Musashi homolog 1 isoform l
NM_001414498.1	NP_001401427.1	RNA-binding protein Musashi homolog 1 isoform l
NM_002442.4	NP_002433.1	RNA-binding protein Musashi homolog 1 isoform a

MSI1 Protein Structure

RRM_1

0
100
200
300
362 a.a.

Protein Preferred Names

Protein Names

RNA-binding protein Musashi homolog 1

musashi-1

Related Diseases

Diseases

Alias

Omsk Hemorrhagic Fever

Ohf	Hemorrhagic Fever, Omsk
Ohf - [Omsk Haemorrhagic Fever]	Spring-Fall Haemorrhagic Fever

Brain Cancer

Adult Brain Tumor	Malignant Neoplasm Of Brain
Brain Neoplasms	Brain Neoplasm
Neoplasm Of Brain	Primary Malignant Neoplasm Of Brain
Brain Tumors	Adult Malignant Brain Neoplasm
Brain Neoplasm, Adult	Bt - Brain Tumour
Malignant Brain Tumour	Malignant Primary Brain Neoplasm
Malignant Primary Brain Tumor	Malignant Tumor Of Adult Brain
Malignant Tumor Of Brain	Primary Brain Neoplasm
Primary Brain Tumor	Tumor Of The Brain
Brain Tumor, Adult	Brain Tumor Primary
Malignant Primary Brain Tumors	Primary Brain Tumors
Cancer, Brain	Brain Tumor, Primary

High Grade Glioma

Malignant Glioma	Glial Cell Tumor
Glioma, Malignant	Malignant Neuroglial Tumor
Neuroglial Tumor	Glioma
Malignant Gliomas

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Gliosarcoma

Glioblastoma With Sarcomatous Component

Sarcomatous Glioblastoma

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119734	Gossypolone		/	Unkown
HY-RS08714	MSI1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MSI1	VGNC	VGNC:68325
Bos taurus	MSI1	VGNC	VGNC:31697
Macaca mulatta	MSI1	VGNC	VGNC:74935
Rattus norvegicus	MSI1	RGD	RGD:628778
Mus musculus	MSI1	MGD	MGI:107376
Canis familiaris	MSI1	VGNC	VGNC:43442

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