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MSI1 - musashi RNA binding protein 1 Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 4440

About MSI1

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,339,662-120,369,164 (from NCBI)

This gene has 3 transcripts (splice variants), 286 orthologues, 36 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 2.5), brain (RPKM 2.0) and 14 other tissues.

Summary

This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in Other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008]

MSI1 Products (15)

mRNA	Protein	Name
NM_001414485.1	NP_001401414.1	RNA-binding protein Musashi homolog 1 isoform b
NM_001414486.1	NP_001401415.1	RNA-binding protein Musashi homolog 1 isoform c
NM_001414487.1	NP_001401416.1	RNA-binding protein Musashi homolog 1 isoform d
NM_001414488.1	NP_001401417.1	RNA-binding protein Musashi homolog 1 isoform e
NM_001414489.1	NP_001401418.1	RNA-binding protein Musashi homolog 1 isoform f
NM_001414490.1	NP_001401419.1	RNA-binding protein Musashi homolog 1 isoform g
NM_001414491.1	NP_001401420.1	RNA-binding protein Musashi homolog 1 isoform h
NM_001414492.1	NP_001401421.1	RNA-binding protein Musashi homolog 1 isoform i
NM_001414493.1	NP_001401422.1	RNA-binding protein Musashi homolog 1 isoform j
NM_001414494.1	NP_001401423.1	RNA-binding protein Musashi homolog 1 isoform j
NM_001414495.1	NP_001401424.1	RNA-binding protein Musashi homolog 1 isoform j
NM_001414496.1	NP_001401425.1	RNA-binding protein Musashi homolog 1 isoform k
NM_001414497.1	NP_001401426.1	RNA-binding protein Musashi homolog 1 isoform l
NM_001414498.1	NP_001401427.1	RNA-binding protein Musashi homolog 1 isoform l
NM_002442.4	NP_002433.1	RNA-binding protein Musashi homolog 1 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables identical protein binding	IPI IPI: Inferred from physical interaction	30367664	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	30367664	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MSI1 Protein Structure

RRM_1

0
100
200
300
362 a.a.

Protein Preferred Names	Protein Names
RNA-binding protein Musashi homolog 1	musashi-1

MSI1 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	MSI1	O43347	HNRNPH2	Homo sapiens	P55795	Validated Y2H	32296183
Intra	MSI1	O43347	HNRNPF	Homo sapiens	P52597	Validated Y2H	32296183
Intra	MSI1	O43347	MSI1	Homo sapiens	O43347	Comigration in SDS	30367664
Intra	MSI1	O43347	MSI1	Homo sapiens	O43347	AFM	30367664

Cross: Cross-species interaction Intra: Intraspecies interaction

MSI1 抗体

製品番号	製品名	アプリケーション	反応性
HY-P83070	Musashi 1/Msi1 Antibody (YA2815)	WB, IHC-P, ICC/IF, IP, FC	Human
HY-P85283	Musashi 1/Msi1 Antibody (YA4975)	WB; IHC-P; IHC-F; IF-Tissue; IP; FC; ICC/IF	Human
HY-P85563	Musashi 1/Msi1 Antibody (YA5255)	WB	Human, Mouse, Rat

関連疾患

Diseases	Alias
Omsk Hemorrhagic Fever	Ohf Hemorrhagic Fever, Omsk Ohf - [Omsk Haemorrhagic Fever] Spring-Fall Haemorrhagic Fever
Brain Cancer	Adult Brain Tumor Malignant Neoplasm Of Brain Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
High Grade Glioma	Malignant Glioma Glial Cell Tumor Glioma, Malignant Malignant Neuroglial Tumor Neuroglial Tumor Glioma Malignant Gliomas
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Gliosarcoma	Glioblastoma With Sarcomatous Component Sarcomatous Glioblastoma
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-119734	Gossypolone		96.28%	Unkown
HY-RS08714	MSI1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22242	Msi1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28764	Msi1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	MSI1	VGNC	VGNC:68325
Bos taurus	MSI1	VGNC	VGNC:31697
Macaca mulatta	MSI1	VGNC	VGNC:74935
Rattus norvegicus	MSI1	RGD	RGD:628778
Mus musculus	MSI1	MGD	MGI:107376
Canis familiaris	MSI1	VGNC	VGNC:43442
Others	MSI1	NCBI