CXXC1 - CXXC finger protein 1 Gene

Also Known as CFP1; CGBP; SPP1; PCCX1; PHF18; hCGBP; ZCGPC1; HsT2645; 2410002I16Rik; 5830420C16Rik

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 30827

About CXXC1

Cytogenetic location: 18q21.1 Genomic coordinates (GRCh38): 18:50,282,347-50,287,692 (from NCBI)

This gene has 18 transcripts (splice variants), 189 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 16.4), lymph node (RPKM 14.4) and 25 other tissues.

Summary

This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain. The protein is a component of the SETD1 complex, regulates gene expression and is essential for vertebrate development. [provided by RefSeq, Sep 2015]

CXXC1 Products (2)

mRNA Protein Name
NM_001101654.2 NP_001095124.1 CXXC-type zinc finger protein 1 isoform 1
NM_014593.4 NP_055408.2 CXXC-type zinc finger protein 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17998332 GOA
enables unmethylated CpG binding IDA
IDA: Inferred from direct assay
10688657 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10688657 GOA
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10688657 GOA
Cellular Component GO Annotation Evidence References Source
part of Set1C/COMPASS complex IDA
IDA: Inferred from direct assay
17998332 GOA
part of Set1C/COMPASS complex IPI
IPI: Inferred from physical interaction
23508102 GOA
part of histone methyltransferase complex IDA
IDA: Inferred from direct assay
17355966 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10688657 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CXXC1 Protein Structure

PHD

PHD: PHD-finger (28 - 76)

zf-CXXC

zf-CXXC: CXXC zinc finger domain (163 - 208)

zf-CpG_bind_C

zf-CpG_bind_C: CpG binding protein zinc finger C terminal domain (400 - 636)

  • 0
  • 200
  • 400
  • 600
  • 656 a.a.
Protein Preferred Names Protein Names

CXXC-type zinc finger protein 1

  • CXXC finger 1 (PHD domain)

CXXC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CXXC1 Q9P0U4 TP53 Homo sapiens P04637
Anti Bait CoIP
23870121
Intra
CXXC1 Q9P0U4 TAX1BP1 Homo sapiens Q86VP1
Validated Y2H
25416956
Intra
CXXC1 Q9P0U4 TAX1BP1 Homo sapiens Q86VP1
Y2H Array
25416956
Intra
CXXC1 Q9P0U4 RBBP5 Homo sapiens Q15291
Anti Tag CoIP
23870121
Intra
CXXC1 Q9P0U4 RBBP5 Homo sapiens Q15291
Anti Bait CoIP
23870121
Intra
CXXC1 Q9P0U4 RBBP5 Homo sapiens Q15291
Anti Tag CoIP
26496610
Intra
CXXC1 Q9P0U4 RBBP5 Homo sapiens Q15291
Anti Tag CoIP
33961781
Intra
CXXC1 Q9P0U4 PTEN Homo sapiens P60484
Anti Tag CoIP
21653829
Intra
CXXC1 Q9P0U4 PTEN Homo sapiens P60484
Y2H Pooling
21653829
Intra
CXXC1 Q9P0U4 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Intra
CXXC1 Q9P0U4 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

CXXC1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82742 CGBP Antibody (YA2487) WB, IHC-F, IHC-P, ICC/IF, FC, IP Human, Mouse, Rat
HY-P82742A CGBP Antibody (YA2487)(PBS only) WB, IHC-F, IHC-P, ICC/IF, FC, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Gait Apraxia
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03413 CXXC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CXXC1 VGNC VGNC:61304
Macaca mulatta CXXC1 VGNC VGNC:71517
Mus musculus CXXC1 MGD MGI:1921572
Rattus norvegicus CXXC1 RGD RGD:1310755
Bos taurus CXXC1 VGNC VGNC:27859
Others CXXC1 NCBI