ADAMTS1 - ADAM metallopeptidase with thrombospondin type 1 motif 1 Gene

Also Known as C3-C5; METH1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9510

About ADAMTS1

Cytogenetic location: 21q21.3 Genomic coordinates (GRCh38): 21:26,835,755-26,845,409 (from NCBI)

This gene has 10 transcripts (splice variants), 207 orthologues and 25 paralogues. Broad expression in ovary (RPKM 126.2), placenta (RPKM 77.2) and 17 other tissues.

Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of Cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]

ADAMTS1 Products (1)

mRNA Protein Name
NM_006988.5 NP_008919.3 A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables metalloendopeptidase activity IDA
IDA: Inferred from direct assay
11278559 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of angiogenesis IDA
IDA: Inferred from direct assay
10438512 GOA
involved in positive regulation of G1/S transition of mitotic cell cycle IGI
IGI: Inferred from genetic interaction
28890348 GOA
involved in positive regulation of vascular associated smooth muscle cell migration IGI
IGI: Inferred from genetic interaction
28890348 GOA
involved in positive regulation of vascular associated smooth muscle cell proliferation IGI
IGI: Inferred from genetic interaction
28890348 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAMTS1 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (70 - 166)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (258 - 467)

TSP_1

TSP_1: Thrombospondin type 1 domain (564 - 613)

ADAM_spacer1

ADAM_spacer1: ADAM-TS Spacer 1 (725 - 842)

TSP_1

TSP_1: Thrombospondin type 1 domain (861 - 909)

TSP_1

TSP_1: Thrombospondin type 1 domain (915 - 966)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 967 a.a.
Protein Preferred Names Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 1

  • ADAM-TS 1

ADAMTS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ADAMTS1 Q9UHI8 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra
ADAMTS1 Q9UHI8 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra
ADAMTS1 Q9UHI8 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Cross
ADAMTS1 Q9UHI8 ns8_sars2 SARS-CoV-2 P0DTC8
Y2H Array
36217030
Intra
ADAMTS1 Q9UHI8 PSMD9 Homo sapiens O00233
Validated Y2H
32814053
Intra
ADAMTS1 Q9UHI8 PSMD9 Homo sapiens O00233
Y2H Array
32814053
Intra
ADAMTS1 Q9UHI8 PSMD9 Homo sapiens O00233
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

ADAMTS1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84862 ADAMTS1 Antibody (YA4559) WB, FC, ELISA Human
HY-P84862A ADAMTS1 Antibody (YA4559)(PBS only) WB, FC, ELISA Human

Related Diseases

Diseases Alias
Premature Menopause

  • Primary Ovarian Insufficiency

  • Premature Ovarian Failure

  • Hypergonadotropic Hypogonadism

  • Premature Ovarian Insufficiency

  • Menopause - Premature

  • Menopause Praecox

  • Menopause Premature

  • Menopause, Premature

  • Female Hypergonadotropic Hypogonadism

  • Hypergonadotrophic Ovarian Failure

  • Primary Female Hypogonadism

  • Pof - [Premature Ovarian Failure]

  • Ovarian Failure

  • Ovarian Secretion Suppression

  • Ovary Hyposecretion

  • Ovary Secretion Deficiency

  • Premature Menopause Nos
Ureteral Obstruction
Chondrosarcoma

  • Cartilaginous Cancer

  • Chondrosarcoma Of Bone

  • Primary Chondrosarcoma Of The Bone

  • CHDSA
Cardiomyopathy, Dilated, 1l

  • Dilated Cardiomyopathy 1l

  • CMD1L

  • Cardiomyopathy, Dilated 1l

  • Cardiomyopathy, Dilated, Type 1l
Keratitis, Hereditary

  • Keratitis

  • Autosomal Dominant Keratitis

  • Hereditary Keratitis

  • Dominantly Inherited Keratitis

  • Keratitis Hereditary

  • KERH
Marfan Syndrome

  • MFS

  • Mfs1

  • Marfan'S Syndrome

  • Marfan Syndrome Type 1

  • Marfan Syndrome, Type I

  • Mass Phenotype

  • Contractural Arachnodactyly

  • Mass Syndrome

  • Octd

  • Overlap Connective Tissue Disease

  • Marfanoid Hypermobility Syndrome

  • Marfan Disease
Aortic Aneurysm, Familial Thoracic 1

  • Thoracic Aortic Aneurysm

  • Annuloaortic Ectasia

  • Familial Thoracic Aortic Aneurysm And Aortic Dissection

  • Familial Aortic Dissection

  • Familial Taad

  • Familial Thoracic Aortic Aneurysm

  • Congenital Aneurysm Of Ascending Aorta

  • Familial Aortic Aneurysm

  • Familial Thoracic Aortic Aneurysm And Dissection

  • Aortic Aneurysm, Thoracic

  • AAT1

  • Faa1

  • Aortic Dissection, Familial

  • Aortic Aneurysm, Familial Thoracic

  • Aneurysm, Thoracic Aortic

  • Faa

  • Ftaad

  • Taa

  • Taad

  • Cystic Medial Necrosis Of Aorta

  • Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection

  • Aortic Aneurysm Thoracic

  • Familial Aortic Aneurysms

  • Aneurysm, Aortic, Thoracic, Familial, Type 1

  • Aneurysm Of Thoracic Aorta

  • Intrathoracic Aneurysm

  • Thoracic Aorta Aneurysm

  • Thoracic Aortic Aneurysm Without Rupture

  • Thoracic Aneurysm

  • Thorax Arterial Aneurysm

  • Thoracic Artery Aneurysm

  • Thoracic Arterial Aneurysm

  • Thorax Aneurysm

  • Thorax Aortic Aneurysm

  • Dissection Of Thoracic Aorta
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00291 ADAMTS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18432 Adamts5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19084 Adamts1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25574 Adamts1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ADAMTS1 RGD RGD:621241
Felis catus ADAMTS1 VGNC VGNC:59587
Canis familiaris ADAMTS1 VGNC VGNC:37590
Macaca mulatta ADAMTS1 VGNC VGNC:80327
Mus musculus ADAMTS1 MGD MGI:109249
Bos taurus ADAMTS1 VGNC VGNC:25614
Others ADAMTS1 NCBI