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GFOD1 - glucose-fructose oxidoreductase domain containing 1 Gene

Also Known as ADG-90; C6orf114

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54438

About GFOD1

Cytogenetic location: 6p24.1-p23 Genomic coordinates (GRCh38): 6:13,357,830-13,487,600 (from NCBI)

This gene has 6 transcripts (splice variants), 200 orthologues and 3 paralogues. Broad expression in brain (RPKM 7.3), fat (RPKM 5.7) and 21 other tissues.

Summary

Predicted to enable nucleotide binding activity and oxidoreductase activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

GFOD1 Products (4)

mRNA	Protein	Name
NM_001242628.2	NP_001229557.1	glucose-fructose oxidoreductase domain-containing protein 1 isoform 2
NM_001242629.2	NP_001229558.1	glucose-fructose oxidoreductase domain-containing protein 1 isoform 3 precursor
NM_001242630.2	NP_001229559.1	glucose-fructose oxidoreductase domain-containing protein 1 isoform 2
NM_018988.4	NP_061861.1	glucose-fructose oxidoreductase domain-containing protein 1 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GFOD1 Protein Structure

GFO_IDH_MocA

GFO_IDH_MocA_C

0
100
200
300
390 a.a.

Protein Preferred Names	Protein Names
glucose-fructose oxidoreductase domain-containing protein 1

GFOD1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GFOD1	Q9NXC2	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	GFOD1	Q9NXC2	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	GFOD1	Q9NXC2	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	GFOD1	Q9NXC2	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	31515488
Intra	GFOD1	Q9NXC2	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956
Intra	GFOD1	Q9NXC2	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	GFOD1	Q9NXC2	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	32296183
Intra	GFOD1	Q9NXC2	MAGEA6	Homo sapiens	P43360	Y2H Array	32296183
Intra	GFOD1	Q9NXC2	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	GFOD1	Q9NXC2	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	GFOD1	Q9NXC2	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	GFOD1	Q9NXC2	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	GFOD1	Q9NXC2	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	GFOD1	Q9NXC2	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	GFOD1	Q9NXC2	HSF4	Homo sapiens	Q9ULV5-2	Validated Y2H	32296183
Intra	GFOD1	Q9NXC2	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	GFOD1	Q9NXC2	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	GFOD1	Q9NXC2	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	GFOD1	Q9NXC2	CCT5	Homo sapiens	P48643	Y2H Pooling	32814053
Intra	GFOD1	Q9NXC2	CCT5	Homo sapiens	P48643	Validated Y2H	32814053
Intra	GFOD1	Q9NXC2	CCT5	Homo sapiens	P48643	Y2H Array	32814053
Intra	GFOD1	Q9NXC2	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	GFOD1	Q9NXC2	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	GFOD1	Q9NXC2	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	GFOD1	Q9NXC2	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	GFOD1	Q9NXC2	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	GFOD1	Q9NXC2	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	GFOD1	Q9NXC2	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	GFOD1	Q9NXC2	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	GFOD1	Q9NXC2	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	GFOD1	Q9NXC2	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	GFOD1	Q9NXC2	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	GFOD1	Q9NXC2	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	GFOD1	Q9NXC2	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	GFOD1	Q9NXC2	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	GFOD1	Q9NXC2	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	GFOD1	Q9NXC2	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	GFOD1	Q9NXC2	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	GFOD1	Q9NXC2	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	GFOD1	Q9NXC2	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	GFOD1	Q9NXC2	KRT31	Homo sapiens	Q15323	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Megalencephalic Leukoencephalopathy With Subcortical Cysts	Vacuolating Megalencephalic Leukoencephalopathy With Subcortical Cysts Mlc Van Der Knaap Disease Lvm Leukoencephalopathy With Swelling And Cysts Megalencephaly-Cystic Leukodystrophy Megalencephalic Leukodystrophy Megalencephaly-Cystic Leukodystorphy Syndrome Infantile Leukoencephalopathy And Megalencephaly Leukoencephalopathy With Swelling And A Discrepantly Mild Course Vacuolating Leukoencephalopathy Megalencephalic Leukodystrophy Megalencephaly-Cystic Leukodystrophy Syndrome Van Der Knaap Syndrome Leukoencephalopathy, Megalencephalic, With Subcortical Cysts
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05382	GFOD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GFOD1	MGD	MGI:2145304
Felis catus	GFOD1	VGNC	VGNC:102429
Macaca mulatta	GFOD1	VGNC	VGNC:72756
Canis familiaris	GFOD1	VGNC	VGNC:41185
Bos taurus	GFOD1	VGNC	VGNC:106753
Rattus norvegicus	GFOD1	RGD	RGD:1311507
Others	GFOD1	NCBI