DHX57 - DExH-box helicase 57 Gene

Also Known as DDX57

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 90957

Summary

Enables RNA binding activity. Predicted to be involved in positive regulation of translation. [provided by Alliance of Genome Resources, Jun 2026]
Broad expression in testis (RPKM 16.0), brain (RPKM 4.7) and 24 other tissues.

DHX57 Products (2)

mRNA Protein Name
NM_001329963.1 NP_001316892.1 putative ATP-dependent RNA helicase DHX57 isoform 2
NM_198963.3 NP_945314.1 putative ATP-dependent RNA helicase DHX57 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DHX57 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DHX57 Q6P158 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra
DHX57 Q6P158 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra
DHX57 Q6P158 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
DHX57 Q6P158 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
25416956
Intra
DHX57 Q6P158 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
DHX57 Q6P158 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
25416956
Intra
DHX57 Q6P158 KRTAP10-9 Homo sapiens P60411
Validated Y2H
25416956
Intra
DHX57 Q6P158 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
32296183
Intra
DHX57 Q6P158 KRTAP10-9 Homo sapiens P60411
Y2H Array
32296183
Intra
DHX57 Q6P158 KRTAP10-5 Homo sapiens P60370
Y2H Prey Pooling
25416956
Intra
DHX57 Q6P158 KRTAP10-5 Homo sapiens P60370
Y2H Array
25416956
Intra
DHX57 Q6P158 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
25416956
Intra
DHX57 Q6P158 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
32296183
Intra
DHX57 Q6P158 KRTAP10-7 Homo sapiens P60409
Y2H Array
32296183
Intra
DHX57 Q6P158 KRTAP9-4 Homo sapiens Q9BYQ2
Y2H Prey Pooling
25416956
Intra
DHX57 Q6P158 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra
DHX57 Q6P158 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra
DHX57 Q6P158 ZNF837 Homo sapiens Q96EG3
Validated Y2H
32296183
Intra
DHX57 Q6P158 ZNF837 Homo sapiens Q96EG3
Y2H Array
32296183
Intra
DHX57 Q6P158 ZNF837 Homo sapiens Q96EG3
Y2H Prey Pooling
32296183
Intra
DHX57 Q6P158 CBX2 Homo sapiens Q14781-2
Y2H Prey Pooling
32296183
Intra
DHX57 Q6P158 CBX2 Homo sapiens Q14781-2
Y2H Array
32296183
Intra
DHX57 Q6P158 RBMY1A1 Homo sapiens P0DJD3-2
Y2H Prey Pooling
32296183
Intra
DHX57 Q6P158 RBMY1A1 Homo sapiens P0DJD3-2
Y2H Array
32296183
Intra
DHX57 Q6P158 KRTAP10-6 Homo sapiens P60371
Y2H Array
32296183
Intra
DHX57 Q6P158 KRTAP10-6 Homo sapiens P60371
Y2H Prey Pooling
32296183
Intra
DHX57 Q6P158 RSPO4 Homo sapiens Q2I0M5
Y2H Prey Pooling
32296183
Intra
DHX57 Q6P158 KRTAP2-4 Homo sapiens Q9BYR9
Validated Y2H
32296183
Intra
DHX57 Q6P158 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
Intra
DHX57 Q6P158 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
Intra
DHX57 Q6P158 PLAGL2 Homo sapiens Q9UPG8
Y2H Array
32296183
Intra
DHX57 Q6P158 PLAGL2 Homo sapiens Q9UPG8
Validated Y2H
32296183
Intra
DHX57 Q6P158 PLAGL2 Homo sapiens Q9UPG8
Y2H Prey Pooling
32296183
Intra
DHX57 Q6P158 CARD10 Homo sapiens Q9BWT7
Y2H Array
32296183
Intra
DHX57 Q6P158 CARD10 Homo sapiens Q9BWT7
Y2H Prey Pooling
32296183
Intra
DHX57 Q6P158 CARD10 Homo sapiens Q9BWT7
Validated Y2H
32296183
Intra
DHX57 Q6P158 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
32296183
Intra
DHX57 Q6P158 ZNF587 Homo sapiens Q96SQ5
Y2H Prey Pooling
32296183
Intra
DHX57 Q6P158 ZNF587 Homo sapiens Q96SQ5
Y2H Array
32296183
Intra
DHX57 Q6P158 CBX2 Homo sapiens Q14781
Y2H Array
25416956
Intra
DHX57 Q6P158 CBX2 Homo sapiens Q14781
Y2H Prey Pooling
25416956
Intra
DHX57 Q6P158 NAA10 Homo sapiens P41227
Y2H Prey Pooling
32296183
Intra
DHX57 Q6P158 NAA10 Homo sapiens P41227
Y2H Array
32296183
Intra
DHX57 Q6P158 ZNF473 Homo sapiens Q8WTR7
Validated Y2H
25416956
Intra
DHX57 Q6P158 ZNF473 Homo sapiens Q8WTR7
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03756 DHX37 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03759 DHX58 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21554 Dhx58 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28072 Dhx58 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown